Patients with lymphoma typically need a bone marrow transplant, a procedure that replaces unhealthy bone marrow with healthy bone marrow. Bone marrow cells are killed with chemotherapy or radiation, and then new, healthy blood-forming cells are given to the patient through an IV. Once the transplant is complete, healthy blood cells begin to develop.
The first FDA-approved CAR T-cell therapy for adults, Yescarta, is an option for adults living with diffuse large B-cell lymphoma who have not responded to standard treatment like chemotherapy or bone marrow transplantation. During this treatment, T-cells are taken from the blood and modified in a laboratory. When this process happens, a receptor called chimeric antigen receptor (CAR) is applied to the T-cells’ outside walls. When your modified T-cells are infused back into your body, the new receptor binds to the cells, enabling the T-cells to target and kill the cancer.
This common cancer treatment involves medication that stops the growth of cancer cells. Your doctor may prescribe oral, injected or intravenous (IV) chemotherapy.
This type of treatment trains the body to prevent, mitigate and get rid of cancer. Adoptive cell transfer, checkpoint inhibitors, cytokines and monoclonal antibodies are some forms of immunotherapy that may be used to treat lymphoma.