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Types of Trials

Pet therapy

There are several types of cancer clinical trials. Each type of trial is designed to answer different research questions.

    • Treatment Trials

      Most cancer clinical trials are treatment studies that involve people who have cancer. These trials test new treatments or new ways of using existing treatments, such as new:

      • Drugs.
      • Vaccines.
      • Approaches to surgery or radiation therapy.
      • Combinations of treatments, including some that work to boost your immune system to help fight the cancer.

      Many newer treatment trials require people to have their tumors tested for genetic changes first to see if treatments targeting specific changes might work better for them than standard treatments.

      Treatment trials are designed to answers questions such as:

      • What is a safe dose of the new treatment?
      • How should the new treatment be given?
      • Does the new treatment help people with cancer live longer?
      • Can the new treatment shrink tumors or prevent them from growing and spreading to new places in the body?
      • What are the new treatment’s side effects?
      • Does the new treatment allow a better quality of life with fewer side effects?
      • Does the new treatment help prevent the cancer from coming back once treatment is finished?
    • ​​​​​​​Prevention Trials

      In most prevention trials, the participants either do not have cancer but are at high risk for developing the disease or have had cancer and are at high risk for developing a new cancer. These studies look at cancer risk and ways to reduce that risk.

      There are two kinds of prevention trials, action studies and agent studies.

      • Action studies ("doing something") focus on finding out whether actions people take—such as exercising more or eating healthy—can prevent cancer.
      • Agent studies ("taking something") focus on finding out whether taking certain medicines, vitamins, minerals, or dietary supplements (or a combination of them) may lower the risk of a certain type of cancer.

      Researchers who conduct these studies want to know:

      • How safe it is for a person to take this agent or do this activity?
      • Does the new approach prevent cancer?
    • Screening Trials

      The goal of cancer screening trials is to test new ways to find disease early, when it may be more easily treated.

      Researchers who conduct cancer screening studies want to know:

      • Does finding disease earlier, before people have any symptoms, save lives?
      • Is one screening test better than another?
      • Do a large number of people who receive the screening test undergo unnecessary follow-up tests and procedures?