Research at Kentucky Neuroscience Institute

At the Kentucky Neuroscience Institute, researchers and clinicians work together to improve the lives of the people of the Commonwealth and beyond. Every day, we work on new treatments and lay the groundwork for the future. Our neurology and neurosurgery research is an essential part of our mission to offer patients the most comprehensive care and innovative treatments. 


We’re advancing patient care through research and clinical programs that range from basic neuroscience research to translational research efforts and advanced clinical trials.

Brain Restoration Center

The Brain Restoration Center investigates ways to heal damaged nerve cells. The University of Kentucky College of Medicine’s Alliance Research Initiative supports our work. 

Learn more about the Brain Restoration Center.

Movement Disorders

Our research into movement disorders includes investigating novel treatments for people with Parkinson's disease, Huntington's disease, tremors and other neurodegenerative illnesses. We’re investigating medications, different approaches to deep brain stimulation, autologous peripheral nerve grafts and other therapies.

Learn more about movement disorders.

Center for Advanced Translational Stroke Science

The Center for Advanced Translational Stroke Science (CATSS) studies various aspects of stroke, from how it evolves to vascular function. We focus on finding ways to protect the brain and improve patient outcomes. 

Find out more about the CATSS.


Our epilepsy research focuses on surgical advances and other treatments for complex epilepsy. Our work includes collaboration with other epilepsy centers around the country. 

Multiple Sclerosis Program

We offer novel therapies through clinical trials for people with multiple sclerosis (MS). Our Multiple Sclerosis and Neuroimmunology program includes research into better understanding and treatment of immunological disorders and viruses that affect the nervous system, with a focus on MS and AIDS. 

Find out more about multiple sclerosis research.

Neuromuscular Disorders

We’re looking for new ways to treat amyotrophic lateral sclerosis (ALS), Duchenne muscular dystrophy, myotonic dystrophy and other neuromuscular disorders. Our current research includes testing medications and other treatments. We’re also investigating whether certain geographical regions of Kentucky and surrounding states are associated with a higher risk for ALS. 

Read more about neuromuscular disorders.


We’re dedicated to advancing knowledge about brain and spinal cord tumors. Working closely with our colleagues at the Markey Cancer Center, we’re focused on patient outcomes and research into advanced surgical options that lead to treatment innovations.

Neuroscience Research Priority Area

The Neuroscience Research Priority Area (NRPA) program supports collaborative research by bringing together researchers and trainees from eight different areas of the university community, including medicine, nursing, engineering and agriculture. The NRPA provides funding and support to advance neuroscience research at the university. 

Learn more about the NRPA

Neurosurgery Research

The Department of Neurosurgery is committed to advancing the field through research. We investigate the safety and effectiveness of various procedures, treatments and technologies. 

Learn more about neurosurgery

Sanders-Brown Center on Aging

Researchers at the Sanders-Brown Center on Aging (SBCoA) are dedicated to understanding the aging process and age-related brain diseases. We also offer education, outreach and clinical programs that promote healthy brain aging. 

Read more about SBCoA.

Alzheimer’s Disease Research Center

For nearly four decades, researchers at the Alzheimer’s Disease Research Center have focused on research, outreach, education and treatment programs. Part of the Sanders-Brown Center on Aging, our efforts include an ongoing study of 800 individuals with and without cognitive impairment. 

Learn more about the Alzheimer’s Disease Research Center.

Memory and Aging Program

The Memory Disorders Clinic offers the chance for people with dementias to take part in promising research protocols. The clinic is a part of the Sanders-Brown Center on Aging and the Alzheimer’s Disease Research Center. 

Find out Memory and Aging Program

Spinal Cord and Brain Injury Research Center

The Spinal Cord and Brain Injury Research Center (SCoBIRC) works on finding effective treatments for people with brain and spinal cord injuries. Our researchers have made promising advances that show the potential to repair damaged neurons. 

Read more about the SCoBRIC

Clinical Trials

Participation in a clinical trial can provide many benefits, including allowing you to receive new treatments before they are widely available. You’ll receive expert care throughout your trial and you’ll help make a difference for future patients by joining us in our research efforts. Clinical trials are federally regulated with built-in safeguards to protect you.

We’re constantly adding new clinical trials. You can ask your healthcare provider if a trial is right for you. Check our list of current clinical trials.