Your browser is not supported. Please upgrade to a modern browser in order to use all the features of the UKHC web application: Firefox | Chrome | Microsoft Edge
Skip to main content
close menu
close menu

Search UK HealthCare

John L. Villano, MD, PhD

Director, Clinical Neuro-Oncology Research Program
John L. Villano, MD, PhD
Request an Appointment Physician Referral


  • Brain Cancer Team
  • Medical Oncology
  • Melanoma (Skin Cancer) Team
This provider offers TeleCare
  • About

    John L. Villano specializes in the treatment of brain cancers. He will advance UK HealthCare's Clinical Neuro-Oncology Research Program, serving as its director. UK HealthCare has a history of being a world-class neuro-oncology program, and he will help carry this tradition into the future.

    Previously, Dr. Villano served as the director of medical neuro-oncology at the University of Illinois Medical Center. He earned a medical degree and doctor of philosophy at the University of Texas Southwestern Medical School at Dallas and trained in neurology at the University of Michigan. He also completed a fellowship in hematology/oncology at the University of Chicago. He is a former American Society of Clinical Oncology track leader for CNS tumors. Currently, he is on the board of the Central Brain Tumor Registry US. He is also a member of the Neuro-Oncology Committee in the cooperative group ALLIANCE and a Society of Neuro-Oncology committee member.

    Faculty Rank

    Medical Director, Precision Medicine Clinic
    Professor of Medicine


    University of Texas Southwestern Medical Center, Dallas


    Neurology, University of Michigan Medical School, Ann Arbor

    Internal Medicine, Cook County Hospital, Chicago


    Hematology/Oncology, University of Chicago

    Certifications and Special Training

    American Board of Internal Medicine

    American Board of Internal Medicine, Medical Oncology

  • Publications

    1. Four-jointed is required for intermediate growth in the proximal-distal axis in Drosophila. Villano, J.L. and Katz, F.N. (1995) Development. 121:2767-77.
    2. NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality. Stupp, R., Wong, E.T., Kanner, A.A., Steinberg, D., Engelhard, H., Heidecke, V., Kirson, E.D., Taillibert, S., Liebermann, F., Dbalý, V., Ram, Z., Villano, J.L., Rainov, N., Weinberg, U., Schiff, D., Kunschner, L., Raizer, J., Honnorat, J., Sloan, A., Malkin, M., Landolfi, J.C., Payer, F., Mehdorn, M., Weil, R.J., Pannullo, S.C., Westphal, M., Smrcka, M., Chin, L., Kostron, H., Hofer, S., Bruce, J., Cosgrove, R., Paleologous, N., Palti, J., Gutin, P.H. (2012) Eur J Cancer. 48(14):2192-202
    3. Incidence of Brain Metastasis at Initial Presentation of Lung Cancer. Villano, J.L., Durbin, E.B., Normandeau, C., Thakkar, J.P., Moirangthem, V., Davis, F.G. (2014) Neuro-Oncol. 17(1):122-8
    4. Epidemiology of Meningiomas Post Public Law 107-206 - The Benign Brain Tumor Cancer Registries Amendment Act. Dolecek, T.A., Dressler, E.V., Thakkar, J.P., Liu, M., Al-Qaisi, A., Villano, J.L. (2015) Cancer. 121(14):2400-10
    5. Incidence of CNS tumors in Appalachian children. Huang, B., Luo, A., Durbin, E.B., Lycan, E., Tucker, T., Chen, Q., Horbinski, C., Villano, J.L. (2017) J Neuro-Oncol. Mar 11. [Epub ahead of print].
  • Research

    Cancer Center Member

    Research Focus

    Clinical Trials involved in Neuro-Oncology and in lung cancer. I am also involved in collaborated with the investigators at Kentucky Cancer Registry (KCR) and at Central Brain Tumor Registry of the United States (CBTRUS) to perform descriptive epidemiology studies. We have worked on topics that are less known or investigated, where application of clinical knowledge assists in interpretation of epidemiology data. 


    • Translational Oncology

    College & Department

    • College of Medicine
    • Department of Internal Medicine

    For Referring Physicians

    800 Rose St.
    CC 446
    Lexington, KY 40536
    United States

Update/Correct This Profile.