Christopher P. DeSimone, MD

  • Associate Chief Medical Officer - Perioperative Services
  • Director of Robotic Surgery

Procedures Performed

  • Cancer-staging procedures
  • Complex hysterectomy
  • Oophorectomy
  • Radical pelvic dissection
  • Robot-assisted laparoscopic procedures
    • Tumor cytoreductive surgery


Chris DeSimone, MD, FACOG, is a graduate of Boston University where he received a degree in Art History. He attended the University of Kentucky, College of Medicine where he graduated with high distinction. He completed residency training in the Department of Obstetrics and Gynecology and his fellowship in the Division of Gynecologic Oncology at the University of Kentucky.

DeSimone is board certified in both obstetrics and gynecology and in the subspecialty of gynecologic oncology. He has been practicing at the UK Markey Cancer since 2005. He holds an appointment as professor of gynecologic oncology in the UK College of Medicine. He is also active in the Society of Gynecologic Oncology and is a board examiner for the American Board of Obstetrics and Gynecology.

Dr. DeSimone previously served on the College of Medicine admissions committee, as the associate residency program director and the director of robotic surgery. In 2016, he branched out from clinical medicine to serve as the Associate Chief Medical Officer of perioperative services. In this role, he coordinated schedules, equipment, staffing and safety of UK HealthCare’s 50 operating rooms in addition to the endoscopy, cath lab and interventional radiology procedural areas. Currently Dr. DeSimone serves as the Chief Medical Officer of Chandler Hospital where he oversees all day-to-day operations.

Personal Statement

I have always been interested in caring for cancer patients. I find it humbling and gratifying to care for complex patients who need surgical and chemotherapy treatments. I chose to specialize in Gynecology Oncology as it allowed me to focus on both aspects.

I have a deep love for international travel, poker, playing/watching soccer, and good food. I'm most happy when cooking, cutting root vegetables and quartering a whole chicken. I find enjoyment out of mentoring residents and fellows as I am profoundly interested in fostering the next generation of physicians. A fun fact about me is that my wife and I recently completed running 1000 consecutive days outdoors, even in the rain, snow, ice, or heat!

Faculty Rank

  • Professor of Gynecologic Oncology

Training & Education


University of Kentucky College of Medicine


University of Kentucky


University of Kentucky

Certifications and Special Training

American Board of Obstetrics and Gynecology
American Board of Obstetrics and Gynecology, Gynecologic Oncology