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Hsin-Sheng Yang, PhD

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hsin-sheng yang
  • About

    Faculty Rank

    Associate Professor
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  • Publications

    1. Down-regulation of tumor suppressor Pdcd4 promotes invasion and activates both b-catenin/Tcf and AP-1 dependent transcription in colon carcinoma cells. Wang Q, Sun Z, and Yang H-S. Oncogene 27:1527-35, 2008.
    2. Down-regulation of E-cadherin is an essential event in activating β-catenin-dependent transcription and expression of its target genes in Pdcd4 knock-down cells. Wang Q, Sun Z, Allgayer H and Yang H-S. Oncogene 29:28-38, 2010.
    3. Down-regulation of Pdcd4 leads to epithelial to mesenchymal transition and promotes metastasis in nude mice. Wang Q, Zhu J, Zhang Y, Sun Z, Guo X, Wang X, Lee E, Bakthavatchalu V, Yang Q, and Yang H-S. Eur J Cancer 49:1761-70, 2013.
  • Research

    Cancer Center Member

    Research Focus

    Dr. Yang's lab studies protein translational control of genes involved in tumor invasion and metastasis. Currently, we focus on investigating how Pdcd4 (Programed cell death 4), a novel tumor suppressor and a translation inhibitor, impacts on protein translation particularly the genes critical for tumor invasion and metastasis. Therefore, our research interests include:

    • Elucidation of the signaling pathways impinged upon tumor invasion and metastasis.
    • Identification and characterization of novel factors involved in protein translation initiation.
    • Development and identification of novel agents or approaches for cancer therapeutics.

    Programs

    • Cancer Cell Biology and Signaling

    College & Department

    • College of Medicine
    • Department of Toxicology and Cancer Biology

    For Referring Physicians

    800 Rose Street
    348 HSRB, University of Kentucky
    Lexington, KY 40536
    United States

    Phone
    859-323-6684