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John A. D'Orazio, MD, PhD

Chief, Division of Hematology/Oncology, Department of Pediatrics
Dr. John A. D'Orazio
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  • Cancer - Pediatric
  • Hematology and Oncology - Pediatric
This provider offers TeleCare
  • Conditions treated

    Pediatric cancers including leukemias, brain tumors and solid tumors such as lymphomas, sarcomas, neuroblastomas, and others,  Hematologic disorders including anemias, thrombocytopenias (low platelet counts), bone marrow failure, and abnormal bleeding/clotting
  • About

    Personal Statement

    I followed my heart to Pediatric Hematology/Oncology. As the first person in my family to even go to college, I really didn't have personal role models to guide my career choices. Medicine proved to be a wonderful way in which I could fuse my desire to help others while attending to my life-long love of learning. I am a physician scientist, and have an active interest in cancer research, focusing on inherited syndromes that predispose to cancer. My journey to Pediatric Heme/Onc was influenced by the inspirational young people and their families battling cancer and blood diseases. I am honored to be a part of the outstanding team here at Kentucky Children's Hospital that provides care to children and young people with cancers and disorders of the blood.

    Faculty Rank

    Professor of Pediatrics


    MD, University of Miami

    PhD, Microbiology and Immunology, University of Miami


    Chief Resident, Pediatrics, Massachusetts General Hospital (MGH), Boston

    Pediatrics, Massachusetts General Hospital (MGH), Boston


    Pediatric Hematology/Oncology, Boston Children's Hospital and the Dana-Farber Cancer Institute (DFCI)

    Certifications and Special Training

    American Board of Pediatrics, Pediatric Hematology/Oncology

  • Publications

    1. Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage. Jarrett, SG, KM Carter, R-M Bautista, D He, C. Wang and JA D’Orazio. J Biol Chem, 2018.
    2. The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage. Jarrett SG, Carter, KM, Shelton, BJ and D'Orazio JA. Scientific Reports. 2017.
    3. Divergence of cAMP signaling pathways mediating augmented nucleotide excision repair and pigment induction in melanocytes. Wolf Horrell EM, Jarrett SG, Carter KM, D'Orazio JA. Experimental Dermatology. 2017
    4. AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair. Jarrett SG, Wolf Horrell EM, D'Orazio JA. Nucleic Acids Research. 2016.
    5. Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes. Jarrett SG, Wolf Horrell EM, Boulanger MC, D'Orazio JA. The Journal of Investigative Dermatology. 2015.
    6. PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage. Jarrett SG, Wolf Horrell EM, Christian PA, Vanover JC, Boulanger MC, Zou Y, D'Orazio JA. Molecular Cell. 2014.
  • Research

    Cancer Center Member

    Research Focus

    Our laboratory focuses on malignant melanoma of the skin, a cancer that kills more than 10,000 Americans every year. Melanoma incidence has increased so much over the last century such that whereas a US citizen in the 1930's had only a 1 in 1,500 chance of developing it, now almost 1 in 50 of us will be diagnosed with the disease. We are interested in the genetic and environmental factors that cause melanomas to develop so that we can design ways to reduce melanoma incidence


    • Molecular and Cellular Oncology

    College & Department

    • College of Medicine
    • Department of Pediatrics

    For Referring Physicians

    Combs Cancer Research Bldg. Rm. 204
    800 Rose Street
    Lexington, KY 40536-0096
    United States

  • Locations

    Danceblue Pediatric Hematology & Oncology

    The DanceBlue Kentucky Children's Hospital Hematology/Oncology Clinic

    Kentucky Children's Hospital
    Kentucky Children's Hospital
    UK Chandler Hospital - Pavilion HA
    800 Rose St.
    Fourth Floor
    Lexington, KY 40536
    Fax 859-257-8978
    Thursday: 8:00 am-12:00 pm or by appointment.

    Patient-centered specialty practice badge

    Insurance Information

    Insurance policies can vary widely. Please check with your doctor/clinic for specific insurance information before your visit or procedure to avoid unexpected out-of-pocket costs. See list of insurers Arrow Pointing Right

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