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John A. D'Orazio, MD, PhD

Chief, Pediatric Hematology and Oncology
Co-Leader, Genomic Instability, Epigenetics and Metabolism
Regina Drury/Children's Miracle Network Endowed Chair in Pediatric Research
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Dr. John A. D'Orazio
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  • Cancer - Pediatric
  • Hematology and Oncology - Pediatric
This provider offers TeleCare
  • About

    Personal Statement

    I think it's very important to make a connection with patients and their families. I'll do anything to make that connection with the families because what I've learned is, to effectively take care of a child with cancer, you need everybody on board. It really does take a village and the most important part of that is the family and that child. One of the great things about being a doctor here at the University of Kentucky and at the Markey Cancer Center is our community of providers and support. We really are invested in the shared mission of trying to bring improved health care to the children and patients of Kentucky.

    Faculty Rank

    Professor of Pediatrics


    University of Miami, School of Medicine, Miami, Fla.


    Massachusetts General Hospital, Boston


    Dana-Farber Cancer Institute, Boston

    Certifications and Special Training

    American Board of Pediatrics, Hematology/Oncology

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  • Publications

    1. Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage. Jarrett, SG, KM Carter, R-M Bautista, D He, C. Wang and JA D’Orazio. J Biol Chem, 2018.
    2. The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage. Jarrett SG, Carter, KM, Shelton, BJ and D'Orazio JA. Scientific Reports. 2017.
    3. Divergence of cAMP signaling pathways mediating augmented nucleotide excision repair and pigment induction in melanocytes. Wolf Horrell EM, Jarrett SG, Carter KM, D'Orazio JA. Experimental Dermatology. 2017
    4. AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair. Jarrett SG, Wolf Horrell EM, D'Orazio JA. Nucleic Acids Research. 2016.
    5. Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes. Jarrett SG, Wolf Horrell EM, Boulanger MC, D'Orazio JA. The Journal of Investigative Dermatology. 2015.
    6. PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage. Jarrett SG, Wolf Horrell EM, Christian PA, Vanover JC, Boulanger MC, Zou Y, D'Orazio JA. Molecular Cell. 2014.
  • Research

    Cancer Center Member

    Research Focus

    Our laboratory focuses on malignant melanoma of the skin, a cancer that kills more than 10,000 Americans every year. Melanoma incidence has increased so much over the last century such that whereas a US citizen in the 1930's had only a 1 in 1,500 chance of developing it, now almost 1 in 50 of us will be diagnosed with the disease. We are interested in the genetic and environmental factors that cause melanomas to develop so that we can design ways to reduce melanoma incidence


    • Genomic Instability, Epigenetics and Metabolism

    College & Department

    • College of Medicine
    • Department of Pediatrics

    For Referring Physicians

    Combs Cancer Research Bldg. Rm. 204
    800 Rose Street
    Lexington, KY 40536-0096
    United States

  • Locations

    Danceblue Pediatric Hematology & Oncology

    The DanceBlue Kentucky Children's Hospital Hematology/Oncology Clinic

    Kentucky Children's Hospital
    Kentucky Children's Hospital
    UK Chandler Hospital - Pavilion HA
    800 Rose St.
    Fourth Floor
    Lexington, KY 40536
    Fax 859-257-8978
    Thursday: 8:00 am-12:00 pm or by appointment.

    Patient-centered specialty practice badge

    Insurance Information

    Insurance policies can vary widely. Please check with your doctor/clinic for specific insurance information before your visit or procedure to avoid unexpected out-of-pocket costs. See list of insurers Arrow Pointing Right

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