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D. Allan Butterfield, PhD

Director, Redox Metabolism Shared Resource Facility
UK Alumni Association Endowed Professor of Biological Chemistry
Director, Center of Membrane Sciences
Faculty, Sanders-Brown Center on Aging
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  • About

    Faculty Rank

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  • Publications

    1. Redox Proteomics in Selected Neurodegenerative Disorders: From its Infancy to Future Applications. Barone E, Cenini G, Sultana R, Di Domenico F, Fiorini A, Perluigi M, Noel T, Wang C, Mancuso C, St Clair DK, Butterfield DA. Antioxid Redox Signal 17(11):1610-55, 2012.
    2. Lack of p53 Decreases Basal Oxidative Stress Levels in Brain Through Up-Regulation of Thioredoxin-1, Biliverdin Reductase-A, Manganese Superoxide Dismutase, and Nuclear Factor-kappa B. Barone E, Cenini G, Sultana R, Di Domenico F, Fiorini A, Perluigi M, Noel T, Wang C, Mancuso C, St Clair DK, Butterfield DA. Antioxid Redox Signal 16(12):1407-20, 2012.
    3. 2-Mercaptoethane Sulfonate Prevents Doxorubicin-Induced Plasma Protein Oxidation and TNF-a Release: Implications for the Reactive Oxygen Species-Mediated Mechanisms of Chemobrain. Aluise CD, Miriyala S, Noel T, Sultana R, Jungsuwadee P, Taylor TJ, Cai J, Pierce WM, Vore M, Moscow JA, St Clair DK, Butterfield DA. Free Radic Biol Med 50(11):1630-8, 2011.
    4. In Vivo Oxidative Stress in Brain of Alzheimer Disease Transgenic Mice: Requirement for Methionine 35 in Amyloid beta-Peptide of APP. Butterfield DA, Galvan V, Lange MB, Tang H, Sowell RA, Spilman P, Fombonne J, Gorostiza O, Zhang J, Sultana R, Bredesen DE. Free Radic Biol Med 48(1):136-144, 2010.
    5. Evidence of Oxidative Damage in Alzheimer's Disease Brain: Central Role for Amyloid beta-Peptide. Butterfield DA, Drake J, Pocernich C, Castegna A. Trends Mol Med 7(12):548-54, 2001.
  • Research

    Cancer Center Member

    Research Focus

    Oxidative stress, redox proteomics, chemotherapy-induced cognitive impairment (chemobrain), Alzheimer's disease.


    • Molecular and Cellular Oncology

    College & Department

    • College of Arts and Sciences
    • Department of Chemistry

    For Referring Physicians

    249 Chemistry-Physics Building
    225 HSRB, University of Kentucky
    Lexington, KY 40506-0055
    United States

  • Locations

    Insurance Information

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