Jianhang Jia, PhD

1. Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila. Jiang K, Liu, Y, Fan J, Epperly G, Gap T, Jiang J, and Jia J. (2014) Proc Natl Acad Sci USA, 111(45): E4842-50, Epub 2014 Oct 27. PMCID: PMC4234617
2. PI(4)P promotes phosphorylation and conformational change of Smoothened through interaction with its C-terminal tail. Jiang K, Fan J, Liu Y, Zhang J, Li XA, Evers BM, Zhu H, and Jia J. (2016) PLoS Biol 14(2): e1002375. PMCID: PMC4749301
3. An obligatory role for neurotensin in high-fat-diet-induced obesity. Li J, Song J, Zaytseva YY, Liu Y, Rychahou P, Jiang K, Starr ME, Kim JT, Harris JW, Yiannikouris FB, Katz WS, Nilsson PM, Orho-Melander M, Chen J, Zhu H, Fahrenholz T, Higashi RM, Gao T, Morris AJ, Cassis LA, Fan TWM, Weiss HL, Dobner PR, Melander O, Jia J†, Evers BM†. (2016) Nature 533(7603): 411-5. (†Senior co-authors jointly supervised this work). PMCID: 5484414 (pertinent to the current application)
4. An intracellular activation of Smoothened that is independent of Hedgehog stimulation in Drosophila. Jiang K, Liu Y, Zhang J, and Jia J. (2018) J Cell Sci 131(1): jcs211367. PMCID: PMC5818065

Cancer Center Member

Research Focus

Programs

• Cancer Cell Biology and Signaling

College & Department

• College of Medicine
• Department of Molecular and Cellular Biochemistry