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- Antitumor effect of intralesional injection with formalin-fixed Toxoplasma gondii organisms on Lewis lung carcinoma in Toxoplasma-infected mice. Suzuki Y and Kobayashi A. Cancer Letters 25:247-254, 1985.
- Interferon-g: The major mediator of resistance against Toxoplasma gondii. Orellana MA, Schreiber RD and Remington JS. Science 240:516-518, 1988.
- Association of CD4+ T cell-dependent, interferon-g-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii. Liesenfeld O, Kosek J, Remington JS and Suzuki Y. J Exp Med 184: 597-607, 1996.
- Removal of Toxoplasma gondii cysts from the brain by perforin-mediated activity of CD8+ T cells. Suzuki, Y., Wang, X, Jortner, B.S., Payne, L., Ni, Y, Michie, S.A., Xu, B., Kudo, T., and Perkins, S. Am. J. Pathol. 176:1607-1613, 2010.
- Cutting Edge: IFN-gamma produced by brain-resident cells is crucial to control cerebral infection with Toxoplasma gondii. Sa, Q., Ochiai, E., Tiwari, A., Perkins, S, Mullins, J. Gehman, M., Huckle, W., Eyestone, W., Saunders, W., Shelton B. J., and Suzuki, Y. J. Immunol. 195: 796-800, 2015.
Cancer Center Member
Our research interest is to understand the molecular mechanisms of the protective immunity to infectious agents. This includes the effects of the infections on development of other diseases such as cancer. We are using murine models of infection with Toxoplasma gondii, an obligate intracellular protozoan parasite. T. gondii establishes a chronic infection by forming cysts preferentially in the brain, and one third of human population worldwide is estimated to be chronically infected with this parasite. Recent epidemiological studies demonstrated that T. gondii infection is associated with a 1.8-fold increase in the risk of brain cancers, and that brain cancer mortality rates increase with T. gondii seroprevalence. These evidences strongly suggest that T. gondii contributes to development of brain cancers and mortality associated with the cancers. Therefore, it is important to prevent infection with this parasite in order to reduce a risk of developing brain cancers and the cancer-associated mortality.
Our research has recently been focused on analyzing the molecular mechanisms of the protective immune responses to T. gondii, especially in the brain and on applying the knowledge obtained from these studies to improve prevention and treatment of the infection. These projects have an excellent potential to provide valuable information for prevention of brain cancers. In addition, I have considerable experience in analyzing the antitumor effects of immunomodulatory agents using murine models of lung carcinoma and lymphoma.
- Cancer Cell Biology and Signaling
College & Department
- College of Medicine
- Department of Microbiology, Immunology and Molecular Genetics