Faculty Rank

  • Professor

Training & Education


NIH Postdoctoral Fellow, Biochemistry, Harvard University, Cambridge, MA, 1972-73, with Professor Konrad Bloch


Ph.D., Harvard University, Cambridge, MA, 1972, with Professor E. J. Corey
A.M., Harvard University, Cambridge, MA, 1969
A.B., Dartmouth College, Hanover, NH, 1967


Research Focus

Development of small-molecule activators and inhibitors relevant to cancer, infectious disease and epilepsy.

Contact Information

421 Bio-Pharm Building
University of Kentucky
Lexington, KY 40536
United States



  1. Phenylethynyl-substituted Heterocycles Inhibit Cyclin D1 and Induce the Expression of Cyclin-dependent Kinase Inhibitor p21Wif1/Cip1 in Colorectal Cancer Cells
    Sviripa, VM; Kril, LM; Zhang, W; Xie, Y; Wyrebek P; Ponomareva, L; Liu, X; Yuan, Y; Zhang, C-G; Watt, DS; Liu, C (2018) MedChemComm, 9(1):87-99.
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  2. Inhibition of Dihydrotestosterone Synthesis in Prostate Cancer by Combined Frontdoor and Backdoor Pathway Blockade
    Fiandalo, MV;. Stocking, JS; Pop, EA; Wilton, JH; Mantione, KM; Li, Y; Attwood, KM; Azabdaftari, G; Wu, Y; Watt, DS; Wilson, EM; Mohler, JL (2018) Oncotarget, 9(13):11227-11242.
    View Publication
  3. Mathematical Modeling of Intracrine Androgen Metabolism in Prostate Cancer: Methodological Aspects
    Cook, SF; Fiandalo, MV; Watt, DS: Wu, Y; Mohler, JL; Bies, RR (2018) Prostate, Jun 25 DOI: 10.1002/pros. 23665.
  4. Efficient Synthesis of Aurone Mannich Bases and Evaluation of their Antineoplastic Activity in PC-3 Prostate Cancer Cells
    Popova, AV; Frasinyuk, MS; Bondarenko, SP; Zhang, W; Xie, Y; Martin, ZM; Cai, X; Fiandalo, MV; Mohler, JL; Liu, C; Watt, DS; Sviripa, VM (2018) Chemical Papers, 72(10): 2443-2456.
  5. A Direct Synthesis of 2-(-Carboxyalkyl)isoflavones from ortho-Hydroxylated Deoxybenzoins
    Mrug, GP; Demydchyk, BA; Bondarenko, SP; Sviripa, VM: Wyrebek, P;. Mohler, JL; Fiandalo, MV; Liu, C; Frasinyuk, MS; Watt, DS (2018) Eur J Org Chem, 39: 5460-5463.
  6. N,N'-Diaryl-Bishydrazones in a Biphenyl Platform: Broad Spectrum Antifungal Agents
    Chandrika, NT; Dennis, EK; Shrestha, SK; Ngo, HX; Green, KD; Kwiatkowski, S; Deaciuc, AG; Dwoskin, LP; Watt, DS; Garneau-Tsodikova, S. (2019) Eur J Med Chem, 164: 273-281.
  7. Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish
    Xie, Y; Kril, LM; Yu, T; Zhang, W; Frasinyuk, MS; Bondarenko, SP; Kondratyuk, KM; Hausman, E; Martin, ZM; Wyrebek, PP; Liu, X; Deaciuc, A; Dwoskin, LP; Chen, J; Zhu, H; Zhan, C-G; Sviripa, VM; Blackburn, J; Watt, DS; Liu, C. (2019) Sci Reports, in press.
  8. Autophagic Flux Modulation by Wnt/β-catenin Pathway in Hepatocellular Carcinoma
    Turcios, L; Chacon, E; Garcia, C; Eman, P; Jiang, J; Spear, B; Liu, C; Watt, DS; Marti, F; Gedaly, R (2019) PLoS One 2019 Feb 22;14(2):e0212538. doi: 10.1371/journal.pone.0212538. eCollection 2019. PMID: 30794613.
  9. Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.
    Zhang W, Sviripa V, Kril LM, Chen X, Yu T, Shi J, Rychahou P, Evers BM, Watt DS and Liu C. J Med Chem 54(5):1288-97, 2011.
  10. Quantification of trans-2,6-difluoro-4‘-dimethylaminostilbene in rat plasma: Application to a pharmacokinetic study.
    Lin HS, Sviripa VM, Watt DS, Liu C, Ong PS, and Ho PC. J Pharm Biomed Anal 72,115-120, 2012.
  11. Fluorinated N,N’-diarylureas as AMPK activators.
    Sviripa V, Zhang W, Conroy MD, Schmidt ES, Liu AX, Truong J, Liu C, Watt DS. Bioorg Med Chem Lett 23(6):1600-1603, 2013.
  12. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A.
    Zhang W, Sviripa V, Chen X, Shi J, Yu T, Ward N, Kril L, Vander Kooi C, Evers M, Watt D, Liu C. ACS Chem Biol 8(4):796-803, 2013.