Hsin-Sheng Yang, PhD

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About

Faculty Rank

  • Associate Professor

Research

Research Focus

Dr. Yang's lab studies protein translational control of genes involved in tumor invasion and metastasis. Currently, we focus on investigating how Pdcd4 (Programed cell death 4), a novel tumor suppressor and a translation inhibitor, impacts on protein translation particularly the genes critical for tumor invasion and metastasis. Therefore, our research interests include:

  • Elucidation of the signaling pathways impinged upon tumor invasion and metastasis.
  • Identification and characterization of novel factors involved in protein translation initiation.
  • Development and identification of novel agents or approaches for cancer therapeutics.

Programs

Molecular and Cellular Oncology

College & Department

Contact Information

800 Rose Street
348 HSRB, University of Kentucky
Lexington, KY 40536
United States

Phone
859-323-6684
Email
hyang3@uky.edu

Publications

  1. Down-regulation of tumor suppressor Pdcd4 promotes invasion and activates both b-catenin/Tcf and AP-1 dependent transcription in colon carcinoma cells.
    Wang Q, Sun Z, and Yang H-S. Oncogene 27:1527-35, 2008.
  2. Down-regulation of E-cadherin is an essential event in activating β-catenin-dependent transcription and expression of its target genes in Pdcd4 knock-down cells.
    Wang Q, Sun Z, Allgayer H and Yang H-S. Oncogene 29:28-38, 2010.
  3. Down-regulation of Pdcd4 leads to epithelial to mesenchymal transition and promotes metastasis in nude mice.
    Wang Q, Zhu J, Zhang Y, Sun Z, Guo X, Wang X, Lee E, Bakthavatchalu V, Yang Q, and Yang H-S. Eur J Cancer 49:1761-70, 2013.