Terrence A. Barrett, MD

  • Chief, Division of Digestive Diseases and Nutrition
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About

I am a board-certified gastroenterologist who specializes in General GI & inflammatory bowel disease (IBD). I am a tenured professor. I trained at University of Chicago (GI with a post-doc in Immunology) and moved to Northwestern University Hospital (NMH) where I was director of IBD and later division chief of GI. My clinical interest is caring for severe refractory IBD. I have been funded through NIH and VA mechanisms x 30yr & currently study epithelial responses in colitis. The primary interest of our laboratory is the impact of mitochondrial respiration in regulating epithelial cell responses in colitis (RO1-funded). This project led to the development of a novel drug (PCT patent pending), AuPhos, that increases mitochondrial function in the intestine and treats colitis in mice (VA merit-funded).

Faculty Rank

  • Professor of Medicine and Microbiology/Immunology

Training & Education

Degree

University of Illinois at Chicago

Residency

Rush Presbyterian St. Luke's Hospital, Chicago

Fellowship

Gastroenterology, University of Chicago IBD, University of Chicago Immunology, University of Chicago

Certifications and Special Training

American Board of Internal Medicine American Board of Internal Medicine, Gastroenterology

Research

Programs

Translational Oncology

College & Department

Contact Information

MN649
W.M. R. Willard Medical Education Building
Lexington, KY 40536
United States

Phone
(859) 323-4887
Email
t.barrett@uky.edu

Publications

  1. "Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease."
    Bradford, E.M.;Ryu, S.H.;Singh, A.P.;Lee, G.;Goretsky, T.;Sinh, P.;Williams, D.B.;Cloud, A.L.;Gounaris, E.;Patel, V.;Lamping, O.F.;Lynch, E.B.;Moyer, M.P.;De Plaen, I.G.;Shealy, D.J.;Yang, G.Y.;Barrett, T.A. Journal of immunology (Baltimore, Md. : 1950) 199, 5 (2017): 1886-1897.
  2. "Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition."
    Feng, Y.;Demehri, F.R.;Xiao, W.;Tsai, Y.H.;Jones, J.C.;Brindley, C.D.;Threadgill, D.W.;Holst, J.J.;Hartmann, B.;Barrett, T.A.;Teitelbaum, D.H.;Dempsey, P.J. Cellular and molecular gastroenterology and hepatology 3, 3 (2017): 447-468.
  3. "Predictors of Chronic Opioid Use in Newly Diagnosed Crohn's Disease."
    Pauly, N.J.;Michailidis, L.;Kindred, M.G.;Flomenhoft, D.;Lofwall, M.R.;Walsh, S.L.;Talbert, J.C.;Barrett, T.A. Inflammatory bowel diseases 23, 6 (2017): 1004-1010.
  4. "Myo-inositol reduces β-catenin activation in colitis."
    Bradford, E.M.;Thompson, C.A.;Goretsky, T.;Yang, G.Y.;Rodriguez, L.M.;Li, L.;Barrett, T.A. World journal of gastroenterology 23, 28 (2017): 5115-5126.
  5. "Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection."
    Cohran, V.;Managlia, E.;Bradford, E.M.;Goretsky, T.;Li, T.;Katzman, R.B.;Cheresh, P.;Brown, J.B.;Hawkins, J.;Liu, S.X.;De Plaen, I.G.;Weitkamp, J.H.;Helmrath, M.;Zhang, Z.;Barrett, T.A. The American journal of pathology 186, 7 (2016): 1837-46.