Richard Higashi, PhD

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About

Faculty Rank

  • Professor

Research

Research Focus

Stable isotope resolved metabolomics.

Programs

Molecular and Cellular Oncology

College & Department

Contact Information

789 S. Limestone
Biopharm 521
Lexington, KY 40536
United States

Phone
859-218-1027
Email
rick.higashi@uky.edu

Publications

  1. Metabolomics-Edited Transcriptomics Analysis of Se Anticancer Action in human lung cancer cells.
    Fan, T. W-M., Bandura, L.L., Lane, A.N. & Higashi, R.M. (2005) Metabolomics 1, 325-339
  2. High information throughput analysis of nucleotides and their isotopically enriched isotopologues by direct-infusion FTICR-MS.
    Lorkiewicz, P., Higashi, R.M., Lane, A.N., Fan, T. W-M. (2012) Metabolomics. 8, 930-939. PMC3477816
  3. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.
    Sellers, K., Fox, M., Bousamra II, M, Slone,S., Higashi, R., Miller, D., Wang, Y., Yan, J., Yuneva, M., Deshpande, R., Lane, A., and Fan, T. (2015) J Clin Invest. 125(2):687-698. doi:10.1172/JCI72873. PMC4319441.
  4. Targeting lactate dehydrogenase-A (LDH-A) inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor initiating cells.
    Xie, H., Hanai,J., Ren, J-G., Kats, L., Burgess ,K., Bhargava, P.,Signoretti,S., Billiard, J., Duffy,K.J., Grant,A, Wang, X., Lorkiewicz, P.K., Schatzman,S., Bousamra II,M., Lane, A.N., Higashi, R.M., Fan, T. W-M., Pandolfi, P.P.P., Sukhatme,V.P., and Seth, P. (2014) Cell Metabolism 19, 795-809.PMC4096909
  5. Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small cell lung cancer study.
    Fan, T.W.M., Marc O. Warmoes, Qiushi Sun, Huan Song, Jadwiga Turchan-Cholewo, Jeremiah T. Martin, Angela Mahan, Richard M. Higashi, and Andrew N. Lane (in press, 2016). Molecular Case Studies (Cold Spring Harbor Press). doi:10.1101/mcs.a000893