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Mariana Nikolova-Karakashian, PhD

Cancer Center Member

Research Programs:
Cancer Cell Biology and Signaling

Colleges & Departments:
College of Medicine, Department of Physiology

Faculty Rank:

Research Focus

Bioactive properties of sphingolipids.

Contact Information

MS513 Chandler Med. Center
Lexington, KY 40536
United States



  1. Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: implications for endothelial apoptosis. Sathishkumar, S., Boyanovsky, B., Karakashian, A.A., Rozenova, K., Giltiay, N.V., Kudrimoti, M., Mohiuddin, M., Ahmed, M.M., Nikolova-Karakashian, M. (2005) Cancer Biol Ther. 4 (9): 979-986
  2. Aging in rats causes hepatic hyperresponsiveness to Interleukin-1β which is mediated by neutral sphingomyelinase-2. Rutkute, K., Karakashian, A., Giltiay, N., Dobierzewska, A. and Nikolova-Karakashian, M.N. (2007) Hepatology 46(4) 1166-1176
  3. Acid sphingomyelinase deficiency prevents diet-induced hepatic triacylglycerol accumulation and hyperglycemia in mice. Deevska, G.M., Rozenova, K.A., Giltiay, N.V., Chambers, M.A., White, J., Boyanovsky, B.B., Wei, J., Daugherty, A., Smart, E.J., Reid, M.B., Merrill, A.H. Jr, Nikolova-Karakashian, M.N. (2009) J Biol Chem. Mar 27;284(13):8359-68.
  4. Studies on the role of acid sphingomyelinase and ceramide in the regulation of TACE activity and TNF{alpha} secretion in macrophages. Rozenova KA, Deevska GM, Karakashian AA, Nikolova-Karakashian MN. (2010) J Biol Chem. Jul 2;285(27):21103-13. doi: 10.1074/jbc.M109.080671. Epub 2010 Mar 17.PMID: 20236926
  5. Interleukin 1β Regulation of FoxO1 Protein Content and Localization: Evidence for a Novel Ceramide-dependent. Dobierzewska, A#, Shi, L.,# (equal first authors) Karakashian, A.A, and Nikolova-Karakashian M.N. (2012) Mechanism J Biol Chem. ; 287(53):44749-60