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Jing Li, MD

Cancer Center Member


Research Programs:
Cancer Prevention and Control

Colleges & Departments:
College of Medicine, Department of Internal Medicine

Faculty Rank:
Assistant Professor

Research Focus

  • Mechanisms how the release of the gut hormone neurotensin is regulated.
  • The role of neurotensin in the development of obesity and metabolic disorders and the underlying mechanisms.
  • The association of neurotensin with aging.
  • Contribution of neurotensin to colorectal cancer associated with obesity.

Contact Information

741 S. Limestone
Lexington, KY 40506
United States



  1. The role of protein kinase D in neurotensin secretion mediated by protein kinase C-alpha/-delta and Rho/Rho kinase. Li J, O'Connor KL, Hellmich MR, Greeley GH Jr, Townsend CM Jr, Evers BM. J Biol Chem. 2004 Jul 2;279(27):28466-74. Epub 2004 Apr 27. PMID: 15123666
  2. Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway. Li J, O'Connor KL, Greeley GH Jr, Blackshear PJ, Townsend CM Jr, Evers BM. J Biol Chem. 2005 Mar 4;280(9):8351-7. Epub 2004 Dec 28. PMID: 15623535
  3. Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and PKA signaling pathways. Li J, O'Connor KL, Cheng XD, Mei FC, Uchida T, Townsend CM Jr, Evers BM. Mol Endocrinol 21:159-171, 2007.
  4. Molecular mechanisms contributing to glutamine-mediated intestinal cell survival. Larson SD, Li J, Chung DH. Am J Physiol Gastrointest Liver Physiol 293:G1262-1271, 2007. Evers BM. PMCID: PMC2432018
  5. PKD1, PKD2 and their substrate Kidins220 regulate neurotensin secretion in the BON human endocrine cell line. Li J, Chen LA, Townsend CM Jr, Evers BM. J Biol Chem 283:2614-2621, 2008. PMCID: PMC2427157