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Andrew N. Lane, PhD

Cancer Center Member

Research Programs:
Drug Discovery, Delivery and Translational Therapeutics

Colleges & Departments:
College of Medicine, Department of Toxicology and Cancer Biology

Faculty Rank:

Research Focus

Cancer biochemistry.

Contact Information

525 Lee T. Todd, Jr. Building - Biopharm Complex
789 S. Limestone St
Lexington, KY 40536
United States



  1. Stability and kinetics of G-quartet structures Lane, A.N.* Chaires, J.B., Gray, R.D. & Trent, J.O. (2008) Nucl. Acids Res. 36, 5482-5515. Survey & Summary Review.doi: 10.1093/nar/gkn517. PMCID: PMC2553573
  2. Myc induction of hypoxic glutamine metabolism and a glucose-independent TCA cycle in human B lymphocytes. Le, A., Lane, A.N.#, Hamaker, M., Bose, S., Barbi, J., Tsukamoto, T., Rojas, C.J., Slusher, B.S., Zhang, H., Zimmerman. L.J., Liebler, D.C., Slebos, R.J.C., Lorkiewicz, P.K., Higashi, R.M., Fan, T.W-M., and Dang, C.V. (2012) Cell Metabolism. 15, 110-121 doi:10.1016/j.cmet.2011.12.009. PMCID:PMC3345194
  3. Pyruvate carboxylase is upregulated in NSCLC. Sellers, K., Fox, M.P., Bousamra, M., Slone, S., Higashi, R.M.,Miller, D.M., Wang, Y., Yan, J., Yuneva, M., Deshpande, R., Lane, A.N., Fan, T. W-M. (2015) J. Clin Invest. 125: 687-698
  4. Regulation of nucleic acid metabolism in mammalian cells. Lane, A.N. & Fan,T-WM. (2015) Nucl.Acids Res. 43, 2466-85
  5. X-ray crystallography and NMR show that 5-formylcytosine does not change the global structure of DNA. Hardwick, J.S., Ptchelkine , D., El Sagheer, A.H., Tear, I., Singleton, D., Phillips, S.E.V., J., Lane, A.N., Brown, T. (2017) Nat. Struct. Biol. 24,544–552
  6. Structure-based profiling of Metabolites and Isotopomers by NMR, Prog. Fan, T.W-M. & Lane, A.N. (2008) NMR Spectrosc. 52, 69-117 doi:10.1016/j.pnmrs.2007.03.002
  7. Altered Regulation of Metabolic Pathways in Human Lung Cancer Discerned by 13C Stable Isotope-Resolved Metabolomics (SIRM). Fan, T.WM., Lane, A.N., Higashi, R.M., Farag, M.A., Gao, H., Bousamra, M. & Miller, D.M. (2009) Molecular Cancer. 8:41 doi:10.1186/1476-4598-8-41. PMCID: PMC2717907
  8. Isotopomer-based metabolomic analysis by NMR and mass spectrometry. Lane, A.N.*, Fan, T-WM. & Higashi, R.M. (2008) Methods in Cell Biology, Vol 84. Biophysical Tools for Biologists, Volume 1, edited by Drs. John J. Correia and H. William Detrich. Elsevier Science & Technology Books Ch. 18. pp 541-588. ISBN: 9780123725202