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Kip Guy, PhD

Cancer Center Member

Dean, University of Kentucky College of Pharmacy

kip guy

Research Programs:
Drug Discovery, Delivery and Translational Therapeutics

Colleges & Departments:
College of Pharmacy, Department of Pharmaceutical Sciences

Faculty Rank:

Research Focus

Chemical biology and drug discovery.

Contact Information

789 S. Limestone
Lexington, KY 40536
United States



  1. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase Scott, D. C.; Hammill, J. T.; Min, J.; Rhee, D. Y.; Connelly, M.; Sviderskiy, V. O.; Bhasin, D.; Chen, Y.; Ong, S.-S.; Chai, S. C.; Goktug, A. N.; Huang, G.; Monda, J. K.; Low, J.; Kim, H. S.; Paulo, J. A.; Cannon, J. R.; Shelat, A. A.; Chen, T.; Kelsall, I. R.; Alpi, A. F.; Pagala, V.; Wang, X.; Peng, J.; Singh, B.; Harper, J. W.; Schulman, B. A.; Guy, R. K. Nature Chem. Biol., 2017, 13(8), 850-857. PMCID: PMC5577376.
  2. Discovery of a Diaminopyrimidine FLT3 Inhibitor Active Against Acute Myeloid Leukemia Jarusiewicz, J. A.; Jeon, J. Y.; Connelly, M. C.; Chen, Y.; Yang, L.; Baker, S. D.; Guy, R. K. ACS Omega, 2017, ao7b00144, PMCID: PMC5452050.
  3. Establishing A Preclinical Multidisciplinary Brain Tumor Board Nimmervoll, B.; Boulos, N.; Bianski, B.; Dapper, J.; DeCuypere, M.; Shelat, A; Terranova, S.; Gilbertson, H.; Gajjar, A.; Patel, Y.; Freeman, B.; Onar-Thomas, A.; Stewart, C.; Roussel, M.; Guy, R. K.; Merchant, T.; Calabrese, C.; Wright, K.; Gilbertson, R. Clin. Cancer. Res. 2018, 24(7), e0006157. PMCID: PMC5884708.
  4. Evaluation of Artemisinins for the Treatment of Acute Myeloid Leukemia Drenberg, C. D.; Buaboonnam, J.; Orwick, S. J.; Hu, S.; Li, L.; Fan, Y.; Shelat, A. A.; Guy, R. K.; Rubnitz, J.; Baker, S. D. Cancer Chemother. Pharmacol. 2016, 77(6), 1231-1243. PMCID: PMC4918815.
  5. Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents Min, J.; Guo, K.; Suryadevara, P. K.; Zhu, F.; Holbrook, G.; Chen, Y.; Feau, C.; Young, B. M.; Lemoff, A.; Connelly, M. C.; Kastan, M. B.; Guy, R. K. J. Med. Chem. 2016, 59(2), 559-577. PMCID: Not applicable.
  6. An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. Cancer Cell. 2011 Sep 13;20(3):384-99. PubMed PMID: 21907928; PubMed Central PMCID: PMC3172881.
  7. Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms. Geistlinger TR, McReynolds AC, Guy RK. Chem Biol. 2004 Feb;11(2):273-81. PubMed PMID: 15123288.
  8. Inactivation of the p53 pathway in retinoblastoma. Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA. Nature. 2006 Nov 2;444(7115):61-6. PubMed PMID: 17080083.
  9. Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma. Morfouace M, Shelat A, Jacus M, Freeman BB 3rd, Turner D, Robinson S, Zindy F, Wang YD, Finkelstein D, Ayrault O, Bihannic L, Puget S, Li XN, Olson JM, Robinson GW, Guy RK, Stewart CF, Gajjar A, Roussel MF. Cancer Cell. 2014 Apr 14;25(4):516-29. PubMed PMID: 24684846; PubMed Central PMCID: PMC3994669.


1996-1998: University of Texas Southwestern Medical Center (UTSWMC) Dallas, TX, Postdoctoral Fellowship in Cellular Biology with Drs. Brown and Goldstein

1991-1996: The Scripps Research Institute (TSRI), La Jolla, CA, Ph.D. in Organic Chemistry with Dr. K. C. Nicolaou

1995: The Woods Hole Research Institute, Woods Hole, MA, Physiology: Cellular and Molecular Biology Course

1986-1990: Reed College, Portland, OR, B.A. in Chemistry