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D. Allan Butterfield, PhD

Cancer Center Member

Director, Redox Metabolism Shared Resource Facility
UK Alumni Association Endowed Professor of Biological Chemistry
Director, Center of Membrane Sciences
Faculty, Sanders-Brown Center on Aging

da-butterfield

Research Programs:

Faculty Rank:
Professor

Research Focus

Oxidative stress, redox proteomics, chemotherapy-induced cognitive impairment (chemobrain), Alzheimer's disease.

Contact Information

249 Chemistry-Physics Building
225 HSRB, University of Kentucky
Lexington, KY 40506-0055
United States

Phone
859-257-3184

Publications

  1. Redox Proteomics in Selected Neurodegenerative Disorders: From its Infancy to Future Applications. Barone E, Cenini G, Sultana R, Di Domenico F, Fiorini A, Perluigi M, Noel T, Wang C, Mancuso C, St Clair DK, Butterfield DA. Antioxid Redox Signal 17(11):1610-55, 2012.
  2. Lack of p53 Decreases Basal Oxidative Stress Levels in Brain Through Up-Regulation of Thioredoxin-1, Biliverdin Rederctase-A, Manganese Superoxide Dismutase, and Nuelear Factor-kapa B. Barone E, Cenini G, Sultana R, Di Domenico F, Fiorini A, Perluigi M, Noel T, Wang C, Mancuso C, St Clair DK, Butterfield DA. Antioxid Redox Signal 16(12):1407-20, 2012.
  3. 2-Mercaptoethane Sulfonate Prevents Doxorubicin-Induced Plasma Protein Oxidation and TNF-a Release: Implications for the Reactive Oxygen Species-Mediated Mechanisms of Chemobrain. Aluise CD, Miriyala S, Noel T, Sultana R, Jungsuwadee P, Taylor TJ, Cai J, Pierce WM, Vore M, Moscow JA, St Clair DK, Butterfield DA. Free Radic Biol Med 50(11):1630-8, 2011.
  4. In Vivo Oxidative Stress in Brain of Alzheimer Disease Transgenic Mice: Requirement for Methionine 35 in Amyloid beta-Peptide of APP. Butterfield DA, Galvan V, Lange MB, Tang H, Sowell RA, Spilman P, Fombonne J, Gorostiza O, Zhang J, Sultana R, Bredesen DE. Free Radic Biol Med 48(1):136-144, 2010.
  5. Evidence of Oxidative Damage in Alzheimer's Disease Brain: Central Role for Amyloid beta-Peptide. Butterfield DA, Drake J, Pocernich C, Castegna A. Trends Mol Med 7(12):548-54, 2001.

Education