Your browser is not supported. Please upgrade to a modern browser in order to use all the features of the UKHC web application: Firefox | Chrome | Microsoft Edge
Skip to main content
close menu
close menu

Search UK HealthCare

Teresa WM Fan, PhD

Cancer Center Member

teresa fan

Research Programs:
Genomic Instability, Epigenetics and Metabolism

Colleges & Departments:
College of Medicine, Department of Toxicology and Cancer Biology

Faculty Rank:

Research Focus

My research focuses on applying systems biochemical approaches including novel Stable Isotope-Resolved Metabolomic (SIRM), metabolomics-edited transcriptomic (META), and proteomic approaches (METPA) which we have developed 1) to investigate the anticancer mechanism of natural products and novel therapeutic agents; 2) to explore the functional role(s) of tumor microenvironment and extrinsic environmental factors in cancer development, progression, and therapy; 3) to uncover novel therapeutic targets and distinct mechanism-informed biochemical marker patterns for human diseases by interrogating the human metabolome; and 4) to decipher the gene networks that govern cancer metabolism. The central tool that I have used to achieve these goals is the integration of nuclear magnetic resonance (NMR) with mass spectrometry (MS) technologies, which enables a systematic interrogation of human metabolic networks and their perturbations by diseases. 

Contact Information

Room 523 Biopharm Complex
789 S. Limestone St.
Lexington, KY 40536
United States



  1. Pyruvate carboxylase is critical in human non-small cell lung cancer. Sellers K, Fox MP, Bousamra M, Slone S, Lane AN, Higashi RM, Miller DM, Wang Y, Yan J, Yuneva MO, Lane AN, Fan T W-M. J Clin Invest 125:687-698, 2015. PMCID: PMC4319441
  2. Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small cell lung cancer study. Fan, T.W.M., Warmoes, M.O., Sun, Q., Song, H., Turchan-Cholewo, J., Martin, J.T., Mahan, A.L., Higashi, R.M. and Lane, A.N. (2016). Cold Spring Harb Mol Case Stud 2016 2:a000893. PMCID: PMC4990809
  3. Applications of NMR spectroscopy to systems biochemistry. Fan, T. W. & Lane, A. N. Prog Nucl Magn Reson Spectrosc92-93, 18-53, doi:10.1016/j.pnmrs.2016.01.005 (2016).