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Anne-Frances Miller, PhD

Cancer Center Member


Research Programs:
Genomic Instability, Epigenetics and Metabolism

Colleges & Departments:
College of Arts and Sciences, Department of Chemistry

Faculty Rank:

Research Focus

  • Enzymes
  • Redox catalysis
  • Flavin-mediated reactions
  • Flavin redox and photochemistry
  • Enzyme-functionalized electrodes and membranes
  • Spectroscopy
  • Mechanistic enzymology
  • Enzyme engineering

Contact Information

CP 113
Chemistry-Physics Building, Lab CP 106
Lexington, KY 40536
United States



  1. Defining Electron Bifurcation in the Electron Transferring Flavoprotein Family Garcia Costas, A. M., Poudel, S., Miller, A.-F., Schut G. J., Ledbetter, R. N., Fixen, K., Seefeldt, L. C., Adams, M. W., Harwood, C. S., Boyd, E. S. Peters, J. W. Accepted by J. Bacteriol.
  2. The Electron Bifurcating FixABCX Protein Complex from Azotobacter vinelandii: Generation of Low-Potential Reducing Equivalents for Nitrogenase Catalysis Ledbetter, R. N. Garcia Costas, A. M., Lubner, C. E., Mulder, D. E., TokminaLukaszewska, M., Artz, J. H., Patterson, A., Magnuson, T. S., Jay, Z. J., Duan, H. D., Miller, J., Plunkett, M. H, Hoben, J. P., Barney, B. M., Carlson, R. P., Miller, A.-F., Bothner, B., King, P. W., Peters, J. W., and Seefeldt, L. C. (2017) In Press, Biochemistry.
  3. A single outer-sphere mutation stabilizes apoMn superoxide dismutase by 35°C and disfavours Mn binding Miller, A.-F. and Wang, T. (2017) In Press, Biochemistry.
  4. Equilibrium and ultrafast kinetic studies manipulating electron transfer: a short-lived flavin semiquinone is not sufficient for electron bifurcation Hoben, J. P., Lubner, C. E., Ratzloff, M. W., Schut, G. J., Nguyen, D. M. N., Hempel, K. W., Adams, M. W. W., King, P. W., Miller, A.-F. (2017) In Press, J. Biol. Chem
  5. Layer-by-Layer assembled laccase enzyme on stimuli-responsive membranes for chloroorganics degradation Sarma, R., Islam, M. S., Miller, A.-F. and Bhattacharyya, D. (2017) ACS Applied Materials & Interfaces 9(17) 14858-14867.