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Jon Thorson, PhD

Cancer Center Member

Co-Leader, Drug Discovery, Delivery, and Translational Therapeutics Research Program


Research Programs:

Faculty Rank:

Research Focus

  • Cancer, infectious disease, inflammation and regenerative medicine.
  • Enzyme mechanism, engineering/evolution and synthetic applications.
  • Lead/probe discovery and development.
  • Natural products discovery and biosynthesis.

Contact Information

463 Todd Building
789 South Limestone Street
Lexington, KY 40504-0596
United States


  1. Structure and specificity of a permissive bacterial C-prenyltransferase. Elshahawi S I, Cao H, Shaaban K A, Ponomareva L V, Subramanian T, Farman Mark L, Spielmann H Peter, Phillips, Jr G N, Thorson Jon S, Singh Shanteri. (2017). Nature Chemical Biology, 13(4), 366-68.
  2. Mccrearamycins A-D, geldanamycin-derived cyclopentenone macrolactams from an eastern Kentucky abandoned coal mine microbe. Wang X, Zhang Y, Ponomareva L V, Qiu Q, Woodcock R, Elshahawi S I, Chen X, Zhou Z, Hatcher B E, Hower James C, Zhan Chang-Guo, Parkin Sean, Kharel M K, Voss S Randall, Shaaban K A, Thorson Jon S. (2017). Angewandte Chemie (International ed. in English), 56(11), 2994–98.
  3. Functional AdoMet isosteres resistant to classical AdoMet degradation pathways. Huber T D, Wang F, Singh Shanteri, Johnson B R, Zhang J, Sunkara M, Van Lanen Steven, Morris Andrew James, Phillips, Jr G N, Thorson Jon S. (2016). ACS Chemical Biology, 11(9), 2484-91.
  4. A divergent enantioselective strategy for the synthesis of griseusins. Zhang Y, Ye Qiang, Wang X, She Qing-Bai, Thorson Jon S. (2015). Angewandte Chemie (International ed. in English), 54(38), 11219-22.
  5. Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-L-methionine analogues. Singh Shanteri, Zhang J, Huber T D, Sunkara M, Hurley K, Goff R D, Wang G, Zhang W, Liu Chunming, Rohr Jurgen, Van Lanen Steven, Morris Andrew James, Thorson Jon S. (2014). Angewandte Chemie (International ed. in English), 53(15), 3965-69.