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Kip Guy, PhD

Dean, University of Kentucky College of Pharmacy
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kip guy
  • About

    Faculty Rank

    Professor

    1996-1998: University of Texas Southwestern Medical Center (UTSWMC) Dallas, TX, Postdoctoral Fellowship in Cellular Biology with Drs. Brown and Goldstein

    1991-1996: The Scripps Research Institute (TSRI), La Jolla, CA, Ph.D. in Organic Chemistry with Dr. K. C. Nicolaou

    1995: The Woods Hole Research Institute, Woods Hole, MA, Physiology: Cellular and Molecular Biology Course

    1986-1990: Reed College, Portland, OR, B.A. in Chemistry

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  • Publications

    1. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase Scott, D. C.; Hammill, J. T.; Min, J.; Rhee, D. Y.; Connelly, M.; Sviderskiy, V. O.; Bhasin, D.; Chen, Y.; Ong, S.-S.; Chai, S. C.; Goktug, A. N.; Huang, G.; Monda, J. K.; Low, J.; Kim, H. S.; Paulo, J. A.; Cannon, J. R.; Shelat, A. A.; Chen, T.; Kelsall, I. R.; Alpi, A. F.; Pagala, V.; Wang, X.; Peng, J.; Singh, B.; Harper, J. W.; Schulman, B. A.; Guy, R. K. Nature Chem. Biol., 2017, 13(8), 850-857. PMCID: PMC5577376.
    2. Discovery of a Diaminopyrimidine FLT3 Inhibitor Active Against Acute Myeloid Leukemia Jarusiewicz, J. A.; Jeon, J. Y.; Connelly, M. C.; Chen, Y.; Yang, L.; Baker, S. D.; Guy, R. K. ACS Omega, 2017, ao7b00144, PMCID: PMC5452050.
    3. Establishing A Preclinical Multidisciplinary Brain Tumor Board Nimmervoll, B.; Boulos, N.; Bianski, B.; Dapper, J.; DeCuypere, M.; Shelat, A; Terranova, S.; Gilbertson, H.; Gajjar, A.; Patel, Y.; Freeman, B.; Onar-Thomas, A.; Stewart, C.; Roussel, M.; Guy, R. K.; Merchant, T.; Calabrese, C.; Wright, K.; Gilbertson, R. Clin. Cancer. Res. 2018, 24(7), e0006157. PMCID: PMC5884708.
    4. Evaluation of Artemisinins for the Treatment of Acute Myeloid Leukemia Drenberg, C. D.; Buaboonnam, J.; Orwick, S. J.; Hu, S.; Li, L.; Fan, Y.; Shelat, A. A.; Guy, R. K.; Rubnitz, J.; Baker, S. D. Cancer Chemother. Pharmacol. 2016, 77(6), 1231-1243. PMCID: PMC4918815.
    5. Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents Min, J.; Guo, K.; Suryadevara, P. K.; Zhu, F.; Holbrook, G.; Chen, Y.; Feau, C.; Young, B. M.; Lemoff, A.; Connelly, M. C.; Kastan, M. B.; Guy, R. K. J. Med. Chem. 2016, 59(2), 559-577. PMCID: Not applicable.
    6. An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. Cancer Cell. 2011 Sep 13;20(3):384-99. PubMed PMID: 21907928; PubMed Central PMCID: PMC3172881.
    7. Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms. Geistlinger TR, McReynolds AC, Guy RK. Chem Biol. 2004 Feb;11(2):273-81. PubMed PMID: 15123288.
    8. Inactivation of the p53 pathway in retinoblastoma. Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA. Nature. 2006 Nov 2;444(7115):61-6. PubMed PMID: 17080083.
    9. Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma. Morfouace M, Shelat A, Jacus M, Freeman BB 3rd, Turner D, Robinson S, Zindy F, Wang YD, Finkelstein D, Ayrault O, Bihannic L, Puget S, Li XN, Olson JM, Robinson GW, Guy RK, Stewart CF, Gajjar A, Roussel MF. Cancer Cell. 2014 Apr 14;25(4):516-29. PubMed PMID: 24684846; PubMed Central PMCID: PMC3994669.
  • Research

    Cancer Center Member

    Research Focus

    Chemical biology and drug discovery.

    Programs

    • Drug Discovery, Delivery and Translational Therapeutics

    College & Department

    • College of Pharmacy
    • Department of Pharmaceutical Sciences

    For Referring Physicians

    789 S. Limestone
    Lexington, KY 40536
    United States

    Phone
    859-257-5290