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Jon Thorson, PhD

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  • About

    Faculty Rank

    Professor
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  • Publications

    Publications

    1. Structure and specificity of a permissive bacterial C-prenyltransferase. Elshahawi S I, Cao H, Shaaban K A, Ponomareva L V, Subramanian T, Farman Mark L, Spielmann H Peter, Phillips, Jr G N, Thorson Jon S, Singh Shanteri. (2017). Nature Chemical Biology, 13(4), 366-68.
    2. Mccrearamycins A-D, geldanamycin-derived cyclopentenone macrolactams from an eastern Kentucky abandoned coal mine microbe. Wang X, Zhang Y, Ponomareva L V, Qiu Q, Woodcock R, Elshahawi S I, Chen X, Zhou Z, Hatcher B E, Hower James C, Zhan Chang-Guo, Parkin Sean, Kharel M K, Voss S Randall, Shaaban K A, Thorson Jon S. (2017). Angewandte Chemie (International ed. in English), 56(11), 2994–98.
    3. Functional AdoMet isosteres resistant to classical AdoMet degradation pathways. Huber T D, Wang F, Singh Shanteri, Johnson B R, Zhang J, Sunkara M, Van Lanen Steven, Morris Andrew James, Phillips, Jr G N, Thorson Jon S. (2016). ACS Chemical Biology, 11(9), 2484-91.
    4. A divergent enantioselective strategy for the synthesis of griseusins. Zhang Y, Ye Qiang, Wang X, She Qing-Bai, Thorson Jon S. (2015). Angewandte Chemie (International ed. in English), 54(38), 11219-22.
    5. Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-L-methionine analogues. Singh Shanteri, Zhang J, Huber T D, Sunkara M, Hurley K, Goff R D, Wang G, Zhang W, Liu Chunming, Rohr Jurgen, Van Lanen Steven, Morris Andrew James, Thorson Jon S. (2014). Angewandte Chemie (International ed. in English), 53(15), 3965-69.
  • Research

    Cancer Center Member

    Research Focus

    • Cancer, infectious disease, inflammation and regenerative medicine.
    • Enzyme mechanism, engineering/evolution and synthetic applications.
    • Lead/probe discovery and development.
    • Natural products discovery and biosynthesis.

    For Referring Physicians

    463 Todd Building
    789 South Limestone Street
    Lexington, KY 40504-0596
    United States