The CS Program’s mission is to identify basic signaling pathways and mechanisms by which cancer cells survive, proliferate, invade and metastasize in an effort to identify novel targets for prevention and treatment. Dovetailing with the cancer center’s mission to reduce cancer incidence and mortality in Kentucky, the CS Program is organized around three key aims: 1) identify aberrant proliferation and survival networks that drive cancer development and progression; 2) define determinants of tumor progression and metastasis; and 3) determine the contribution of the tumor microenvironment to cancer progression.
The CS Program’s highly collaborative, diverse members have identified critical signaling pathways that mediate proliferation and survival, invasion and metastasis, and therapeutic resistance. Their work has also defined critical links between obesity and cancer.
The CS Program’s monthly meetings are used to discuss research in progress, and often feature members of other scientific programs and shared resource leaders. The CS Program also has an annual retreat.
CS members are active in the cancer center’s cancer stem cell group, breast cancer translational group, and GI cancer translational group.