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2nd Annual Precision Medicine Symposium: Advances in Immunotherapies

April 13, 2018 – April 14, 2018 | Lexington, KY

The 2nd Annual Precision Medicine Symposium will highlight new advances in immunotherapy and how it is changing the cancer landscape as a fourth major treatment option.  This free regional program is designed for oncologists, hematologists, pathologists, oncology nurses, researchers, pharmacists, genetic counselors, cancer center administrators and cancer program leaders.

On Friday, April 13th, attendees will learn about the basics of cancer immunology, biomarkers to predict immunotherapy and the latest clinical advances in immunotherapy, including CAR-T cell therapy.

On Saturday, April 14th, attendees will explore practical ways to offer precision medicine options to their patients, including an overview of available next-generation sequencing tests and when to order them as well as information about potential treatment strategies for specific mutations.

Watch a video recapping of last year’s meeting below.

  • Register

    Register for the 2nd Annual Precision Medicine Symposium here. Participants can register online or in-person at the symposium.

    There is no registration cost for this event.

    Continuing Education

    CE credit will be available for all physicians, pharmacists, and nurses who attend the program. Find more information regarding CE Credit for the event.

    Program Objectives

    • Describe the development & clinical use of CAR-T cells.
    • Review the place in therapy of currently available immunotherapies.
    • Discuss strategies to manage adverse effects associated with immunotherapies.
    • Explain the use of biomarkers to select patients for treatment with immunotherapies.
    • Identify unique aspects of assessing response to immunotherapies.
    • Describe ongoing clinical trials testing immunotherapies at the Markey Cancer Center.
  • Agenda - Day 1

    Download the full agenda for Day 1 and Day 2 here. (PDF, 97.4 KB)

    Day 1: Friday, April 13, 2018

    • 8 a.m. – 4:30 p.m.
    • Griffin Gate Marriott

    This symposium begins with presentations to learn about the basics of cancer immunology, biomarkers to predict immunotherapy and the latest clinical advances in immunotherapy. This day will feature both of our keynote speakers, Dr. Jeffrey Sosman and Dr. Renier Brentjens.  In addition to the presentations, there will be interactive discussions as well as the opportunity to participate in two different workshops.


    Welcome and Introductions

    8 – 8:30 a.m.

    Robert DiPaola, MD
    Dean, College of Medicine
    University of Kentucky

    B. Mark Evers, MD, FACS
    Director, Markey Cancer Center
    University of Kentucky

    Overview of Immunology & the Basis of Immunotherapy                                                  

    8:30 – 9 a.m.

    Val Adams, PharmD
    Associate Professor, College of Pharmacy
    University of Kentucky

    • Describe the key components of the immune system.
    • Understand the mechanism of action of new immunotherapies.

    General Session I: Clinical Update in Immunotherapy for Solid Tumors

    Keynote 1: Recent Advances in the Treatment of Melanoma & Renal Cell Cancers

    9 – 9:45 a.m.

    Jeffrey Sosman, MD
    Professor of Medicine
    Feinberg School of Medicine
    Northwestern University

    • Apply results of immunotherapy clinical trial to the treatment melanoma & renal cell cancer.
    • Describe the place in therapy of novel immunotherapies.

    The Role of Immunotherapy in the Treatment of Lung Cancer

    9:45 – 10 a.m.

    John Villano, MD, PhD
    Professor, College of Medicine
    University of Kentucky

    • Compare & contrast the use and effectiveness of immunotherapy in the treatment of lung cancer.
    • Outline the effective use of cancer genetic data when considering immunotherapy to inform treatment selection & potential immune response.

    General Session I Discussion

    10 - 10:30 a.m.

    Moderated by Jessica Croley, MD
    Medical Oncologist
    KentuckyOne Health


    Break

    10:30 – 11 a.m.


    Workshop 1

    (Attendees select one)

    11 – 11:45 a.m.

    1. Immunotherapy in Challenging Populations, with Tom Badgett, MD, PhD, Lowell Anthony, MD, FACP, and Gregory Monohan, MD
      • Describe the role of immunotherapy in pediatric and geriatric populations.
      • Discuss the use of immotherapies in the immune compromised patient.
    2. Adverse Effects – Hands-on Trouble Shooting, with Aju Mathew, MD, FACP, MPhil, Rachael Morgan, PharmD, BCOP and Holly Chitwood, APRN
      • Develop strategies to manage common adverse effects of immunotherapies.
      • Recognize adverse effects of immunotherapies.
    3. Optimizing Technical Aspects & Interpretation of Biomarkers, with Virgilius Cornea, MD and Kurt Hodges, MD, MBA.
      •  Discuss the appropriate use of clinically relevant immunotherapy biomarkers.
      • Understand the results presented in a immunotherapy biomarker report.
    4. Unique Aspects of Immunotherapy, with Michael Brooks, MD and Aleksander Lenert, MD, FRCPC
      • Develop strategies to assess clinical responses.
      • Recognize and manage immunotherapy induced rheumatic adverse effects.

    Lunch & Poster Session

    11:45 a.m. – 1:15 p.m.


    Workshop 2

    (Attendees select one)

    1:15 – 2 p.m.

    1. Immunotherapy in Challenging Populations, with Tom Badgett, MD, PhD, Lowell Anthony, MD, FACP, and Gregory Monohan, MD
      • Describe the role of immunotherapy in pediatric and geriatric populations.
      • Discuss the use of immotherapies in the immune compromised patient.
    2. Immunotherapy Clinical Trials at Markey Cancer Center, with Jacob Hodskins, MD, MS
      • Describe unique considerations for clinical trial designs in immunotherapeutic agents.
      • Assess the current immunotherapy clinical trial portfolio for relevance to your patient population.
      • Identify gaps in the current clinical trials portfolio.
    3. Combining Immunotherapy & Radiation, with Ronlad McGarry, MD, PhD
      • Describe the influence of immunotherapy on the abscopal effect.
      • Address strategies to optimize timing and sequencing of combination therapy for maximal synergy.
    4. Animal Models & Translational Research, with Tianyan Gao, PhD and Christine Fillmore Brainson, PhD
      • Understand the role of the innate immune response in colon cancer carcinogenesis.
      • Describe the role of immune system in lung cancer development and sensitivity to therapies.

    Break

    2 – 2:15 p.m.


    General Session II: Biomarkers & Response Assessment

    Biomarkers of Response I: Tumor Mutation Burden & PD-1

    2:15 – 2:30 p.m.

    Jill Kolesar, PharmD, MS
    Professor, College of Pharmacy
    University of Kentucky

    • Assess the role of PD-L1 testing in predicting response to immunotherapy.
    • Understand and apply tumor mutation burden, and microsatellite instability as predictive biomarkers.

    Biomarkers of Response II: Immune Markers

    2:30 – 2:45 p.m.

    Don Cohen, PhD
    Professor, College of Medicine
    University of Kentucky

    • List methods for quantifying and characterizing T cells.
    • Understand novel methods for assessing immune response to immunotherapy.

    Immune therapy in Hematological Malignancies: An Overview

    2:45 – 3:15 p.m.

    Gerhard Hildebrandt, MD
    Professor, College of Medicine
    University of Kentucky

    • Describe immunological principles in treating patients with hematologic cancers.
    • Understand the clinical development of immune checkpoint inhibitors in the treatment of lymphoma.

    Keynote 2: CART-T Cell Therapy

    3:15 – 4 p.m.

    Renier Brentjens, MD, PhD
    Director, Cell Therapeutics
    Memorial Sloan Kettering Cancer Center

    • Describe the process for generating CAR-T cells.
    • Understand the place in therapy of CAR-T cells for hematologic malignancies.

    General Session II Discussion

    4 – 4:15 p.m.

    Moderated by Adam Lye, MD
    Medical Oncologist
    Hardin Memorial Health


    Wrap-up and Introduction of the ORIEN Network

    Jill Kolesar, PharmD, MS
    Professor, College of Pharmacy
    University of Kentucky

    • Assess the strategies of the ORIEN network.
    • Develop strategies to enroll patients in Total Cancer Care.
  • Agenda - Day 2

    Download the full agenda for Day 1 and Day 2 here. (PDF, 97.4 KB)

    Day 2: Saturday, April 14, 2018

    • 8 a.m. – Noon
    • Griffin Gate Marriott

    The second day of the symposium is a hands-on workshop that will include an overview of available next-generation sequencing tests and when to order them as well as presentations on treatment updates for a variety of solid tumors. This day is a part of the Precision Medicine Certificate program at the Markey Cancer Center

    After the workshop, attendees will have the opportunity to attend the horse races occurring at Keeneland on their own.


    Next Generation Sequencing Tests: What They Are & When to Order Them

    8 – 8:45 a.m.

    Jill Kolesar, PharmD, MS
    Professor, College of Pharmacy
    University of Kentucky

    1. Describe the basic methods and samples used for next generation sequencing.
    2. Differentiate common next generation sequencing tests.

    Introduction to Markey Cancer Center Guidance Documents

    8:45 – 9:15 a.m.

    Elizabeth Beckman, PharmD
    Clinical Knowledge Management Analysis
    UK HealthCare

    • Discuss the process for guidance document development.
    • Develop strategies for using guidance documents in clinical practice.

    Clinical Update on Lung Cancer: When to Test & Emerging Therapies

    9:15 – 9:45 a.m.

    Zhonglin Hao, MD, PhD
    Associate Professor, College of Medicine
    University of Kentucky

    • Determine appropriate lung cancer patients for NGS sequencing.
    • Interpret NGS sequencing reports and select targeted therapies for lung cancer patients.

    Clinical Update on Ovarian Cancer: When to Test & Emerging Therapies

    9:45 – 10:15 a.m.

    Rachel Miller, MD
    Associate Professor, Obstetrics and Gynecology
    University of Kentucky

    • Determine appropriate ovarian cancer patients for NGS sequencing.
    • Interpret NGS sequencing reports and select targeted therapies for ovarian cancer patients. 

    Break

    10:15 – 10:30 a.m.


    Clinical Update on GI Cancer: When to Test & Emerging Therapies

    10:30 – 11 a.m.

    Ravneet Thind, MD
    Assistant Professor, Internal Medicine
    University of Kentucky

    • Determine appropriate GI cancer patients for NGS sequencing.
    • Interpret NGS sequencing reports and select targeted therapies for GI cancer patients. 

    Clinical Update on Breast Cancer: When to Test & Emerging Therapies, with Edward Romond, MD

    11 – 11:30 a.m.

    Edward Romond, MD
    Professor, College of Medicine
    University of Kentucky

    • Determine appropriate breast cancer patients for NGS sequencing.
    • Interpret NGS sequencing reports and select targeted therapies for breast cancer patients. 

    Wrap-up & Presentation of Precision Medicine Certificates

    11:30 a.m. – Noon

  • Keynote Speakers

    &Dr. Sosman

    Jeffrey A. Sosman, MD
    Northwestern University
    Professor, Medicine, Hematology & Oncology
    Co-leader, Northwestern Cancer Center Translational Research in Solid Tumors (TRIST)

    Focus areas: immune checkpoint therapy, personalized therapy for melanoma, translational research

    Dr. Brentjens

    Renier J. Brentjens, MD, PhD
    Memorial Sloan Kettering
    Director, Cellular Therapeutics

    Focus areas: immunotherapy for leukemias & lymphomas, translational research

     

  • Call for Abstracts

    Take the first step toward highlighting your research by submitting an abstract for the Precision Medicine Symposium poster session.  Symposium attendees and researchers from Markey Cancer Center are encouraged to submit a poster abstract detailing their experiences and innovations in cancer immunology and immunotherapy.

    Accepted poster presentations will be on display Friday, April 13, 2018, during the lunch break, allowing researchers to network and to discuss their work with symposium attendees.

    Important Dates

    • Friday, March 20, 2018, Noon EST – Deadline to submit an abstract
    • Friday, April 13, 2018, 11:45 a.m. – 1:15 p.m. – Poster Session at Precision Medicine Symposium

    Abstract Type/Category

    Submissions are encouraged for topics related to developing, implementing, and optimizing patient care delivery in immunotherapy.

    Submit an abstract here.

    All completed and eligible abstracts will be made available to the reviewers for review & scoring, with final decisions to be made by the Program Committee in late March 2018. Incomplete abstracts will not be reviewed.

    Responsibilities of the Presenting Author

    All authors will be asked to confirm that they are submitting their abstract with the intent of attending the 2nd Annual Precision Medicine Symposium and that each co-author has been informed of this abstract submission and has agreed to all information as it was submitted.

    Poster Session

    Accepted abstracts will be scheduled for an open poster session during the Precision Medicine Symposium. The purpose of the Poster session is to encourage conference attendees and speakers to informally discuss current projects, research, and innovations in immunotherapy with colleagues.

    Printed posters should be created in the following dimensions: 36” x 48”

  • Exhibitors and Sponsors

    The 2nd Annual Precision Medicine Symposium will be held at the Griffin Gate Marriott in Lexington, KY. Exhibitors & supporters have the opportunity to be highlighted at the symposium.

    Become an Exhibitor

    Exhibitors at the Precision Medicine Symposium will enjoy the following benefits:

    • A dedicated booth at the Griffin Gate Marriott on day one of the symposium
    • Free exhibitor registration
    • Acknowledgement at the symposium via signs and materials

    Please contact us if you are interested in exhibiting at the conference.

    Become a Sponsor

    Groups may sponsor a specific portion of the Precision Medicine Symposium in any amount they choose. Groups that provide support will be credited at the event and on the conference website.

    Please contact us if you are interested in becoming a symposium sponsor.

    All exhibitors/sponsors will need to complete & sign the Exhibitor Agreement before registration and send to Marissa.schuh@uky.edu.

  • Venue

    Griffin Gate MarriotThe 2nd Annual Precision Medicine Symposium will take place at the Griffin Gate Marriott Resort and Spa.

    Griffin Gate Marriott Resort and Spa
    1800 Newtown Pike,
    Lexington KY 40511

    Conference Parking & Transportation

    • Transportation to the conference will not be provided.
    • Complimentary on-site parking is available for all symposium attendees. There is a valet parking for a daily fee of $20.00.

    Hotel Accommodations

    There is a block of rooms reserved at the Griffin Gate Marriott for the Symposium. Reserved rooms can be booked here.