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Cardiovascular Genetics and Precision Medicine

The Cardiovascular Genetics and Precision Medicine Program at the UK Gill Heart & Vascular Institute specializes in the diagnosis and treatment of familial cardiovascular diseases, and in researching novel approaches to preventing and treating those diseases.

Precision medicine – an individualized treatment approach that takes into account a person’s genes, environment and lifestyle – is the new frontier of healthcare, and this highly specialized program is proud to be the first dedicated cardiogenetics program in Kentucky and the region.

The charge of the program is to:

  • Provide comprehensive clinical genetic service to inpatients and outpatients.
  • Facilitate and engage in clinical genetics and genomics research.
  • Promote the genetic and genomic education of faculty, staff and students.

Our clinicians and researchers work to understand the role genetics play in cardiovascular disease on both the individual and the societal level.

We evaluate adults with a broad variety of hereditary conditions, including chromosomal abnormalities, congenital heart disease, monogenic syndromes, complex and common disorders, family history of genetic conditions, or abnormal genetic testing. Our team provides evaluation and management recommendations based on the genomic status of patients with familial and unknown etiology heart disorders.

  • Genetic tests

    A full array of diagnostic and pre-symptomatic genetic testing is available, including:

    • Single gene analysis (sequencing and deletion/duplication analysis).
    • Targeted or familial mutation analysis.
    • Multigene cardiovascular panels.
    • Whole exome sequencing (WES).
    • Whole genome sequencing (WGS).
    • Microarrays and chromosomal studies.
    • Pharmacogenomics panels.
  • Clinical services

    We provide clinical evaluation, analysis of family history, diagnostic testing and genetic counseling of adult patients with:

    • Coronary artery disease, myocardial infarction.
    • High cholesterol and dyslipidemias.
    • Cardiomyopathies and heart failure.
    • Arrhythmia, syncope, sudden cardiac death.
    • Thoracic aorta aneurysm and dissection.
    • Syndromic connective tissue disorders (including Marfan syndrome and Ehlers-Danlos syndrome).
  • Referrals

    Common referrals are patients with:

    • Familial or early-onset coronary artery disease.
    • Dyslipidemias.
    • Cardiomyopathy.
    • Heart failure.
    • Arrhythmias.
    • Sudden cardiac death.
    • Hereditary connective tissue disorders including Marfan syndrome and Ehlers-Danlos syndrome.
    • Aorta aneurysms.
    • Vascular disorders.
    • Abnormal cardiovascular imaging.
    • Positive family history or prior genetic testing.

    To refer a patient, please call 859-323-3231, Ext. 9.