Terrence A. Barrett, MD

Chief, Division of Digestive Diseases and Nutrition

Clinical interests

  • Chromoendoscopy
  • Colitis-induced Dysplasia
  • Crohn's Disease
  • Management of Complex Inflammatory Bowel Disease
  • Ulcerative Colitis

Terrence A. Barrett, MD

Chief, Division of Digestive Diseases and Nutrition


My name is Terrence Barrett; I join the UK HealthCare faculty from Northwestern Memorial Hospital where I have been on staff since 1992 and a professor in the Division of Gastroenterology since 2008. I came to Lexington in June as Chief of Gastroenterology.

After receiving my medical degree from the University of Illinois, I completed a residency at Rush Presbyterian St. Luke’s Hospital in Chicago. I completed fellowships in gastroenterology, IBD and immunology at the University of Chicago.

I am the recipient of numerous prestigious research grants from the National Institutes of Health and the Crohn’s and Colitis Foundation of America. I serve on the editorial board of numerous national and international journals and have authored more than 200 articles, abstracts, book reviews and editorials.

I specialize in complex inflammatory bowel disease and am part of a NCI clinical trial for patients with colitis-induced dysplasia.

I have expertise in chromoendoscopy and the evaluation and detection of colitis-induced dysplasia. I am one of only a few physicians, nationally, who have experience in this procedure. I am available for direct referrals for colonoscopy with chromoendoscopy in patients needing colitis surveillance.

Faculty rank

Professor of Medicine and Microbiology/Immunology


University of Illinois at Chicago

Rush Presbyterian St. Luke's Hospital, Chicago

Gastroenterology, University of Chicago
IBD, University of Chicago
Immunology, University of Chicago

Certifications or Special training
American Board of Internal Medicine
American Board of Internal Medicine, Gastroenterology

Digestive Diseases & Nutrition

Kentucky Clinic
Second Floor, Wing C, Room D211
740 S. Limestone
Lexington KY 40536-0284

Call 859-323-0079
Fax 859-257-9501

Dining, Internet/Wi-Fi, Information desk, Pharmacy services, Wheelchairs

Parking is available at the Kentucky Clinic Parking Garage (PS #3).

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Referral form for physicians »

  1. Cohran V, Managlia E, Bradford EM, Goretsky T, Li T, Katzman RB, Cheresh P, Brown JB, Hawkins J, Liu SX, De Plaen IG, Weitkamp JH, Helmrath M, Zhang Z, Barrett TA.
    Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection.
    Am J Pathol. 2016 Jul;186(7):1837-46.
  2. Goretsky T, Bradford EM, Ryu H, Tahir M, Moyer MP, Gao T, Li L, Barrett TA.
    A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer.
    J Biol Chem. 2016 Feb 19;291(8):4166-77.
  3. Gounaris E, Ishihara Y, Shrivastrav M, Bentrem D, Barrett TA.
    Near-Infrared Fluorescence Endoscopy to Detect Dysplastic Lesions in the Mouse Colon.
    Methods Mol Biol. 2016;1422:137-47.
  4. Wen YA, Li X, Goretsky T, Weiss HL, Barrett TA, Gao T.
    Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.
    Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2013-23.
  5. Wang Y, Liu X, Pijut SS, Li J, Horn J, Bradford EM, Leggas M, Barrett TA, Graf GA.
    The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination.
    J Lipid Res. 2015 Apr;56(4):810-20.