Stephen J. Ryan, MD

Director, EEG Lab

Clinical interests

  • Clinical Neurophysiology
  • Electroencephalography
  • Electromyography
  • Myasthenia Gravis
  • Myopathy
  • Neuromuscular Disease
  • Neuropathies
  • Quantitative Sensory Testing
  • Stroke

Stephen J. Ryan, MD

Director, EEG Lab

Biography

My name is Stephen J. Ryan; I received my medical degree from the University of Missouri Columbia School of Medicine, Columbia. I then completed a fellowship at the University of Kentucky, Lexington.

I am board certified by the American Board of Psychiatry and Neurology in Clinical Neurophysiology and Neuromusclar Medicine.

Faculty rank

Professor of Neurology

Education

Degree
University of Missouri Columbia School of Medicine, Columbia

Residency
University of Kentucky, Lexington

Fellowship
University of Kentucky, Lexington

Certifications or Special training
American Board of Psychiatry and Neurology
American Board of Psychiatry and Neurology, Neuromuscular Medicine
American Board of Psychiatry and Neurology, Clinical Neurophysiology

Neurology

Kentucky Neuroscience Institute

Kentucky Clinic
First Floor, Wing C, Room B101
740 S. Limestone
Lexington KY 40536-0284

Call 859-323-5661
Fax 859-323-3753

Amenities
Dining, Internet/Wi-Fi, Information desk, Pharmacy services, Wheelchairs

Parking is available at the Kentucky Clinic Parking Garage (PS #3).

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Insurance information

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  1. Dou G, Sreekumar PG, Spee C, He S, Ryan SJ, Kannan R, Hinton DR. Deficiency of aB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med. 2012 Sep 1; 53(5):1111-22. PMID: 22781655.
    View in: PubMed
  2. Sreekumar PG, Spee C, Ryan SJ, Cole SP, Kannan R, Hinton DR. Mechanism of RPE cell death in a-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS One. 2012; 7(3):e33420. PMID: 22442691.
    View in: PubMed
  3. Xu J, Zhu D, Sonoda S, He S, Spee C, Ryan SJ, Hinton DR. Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Angiogenesis. 2012 Jun; 15(2):213-27. PMID: 22392094.
    View in: PubMed
  4. Shang Y, Cheng R, Dong L, Ryan SJ, Saha SP, Yu G. Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram. Phys Med Biol. 2011 May 21; 56(10):3015-32. PMID: 21508444.
    View in: PubMed
  5. Ryan SJ. With looming budget cuts, vision research advocacy is vital. Optom Vis Sci. 2011 Apr; 88(4):454-5. PMID: 21430501.
    View in: PubMed
  6. Sreekumar PG, Kannan R, Kitamura M, Spee C, Barron E, Ryan SJ, Hinton DR. aB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells. PLoS One. 2010; 5(10):e12578. PMID: 20949024.
    View in: PubMed
  7. Zhou J, He S, Zhang N, Spee C, Zhou P, Ryan SJ, Kannan R, Hinton DR. Neutrophils compromise retinal pigment epithelial barrier integrity. J Biomed Biotechnol. 2010; 2010:289360. PMID: 20204129.
    View in: PubMed
  8. Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, Ryan SJ, Kannan R, Hinton DR. alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 2010 Apr 22; 115(16):3398-406. PMID: 20023214.
    View in: PubMed
  9. Sonoda S, Spee C, Barron E, Ryan SJ, Kannan R, Hinton DR. A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells. Nat Protoc. 2009; 4(5):662-73. PMID: 19373231.
    View in: PubMed
  10. Jones N, Hardes G, Ryan S, Sheehan J, Cox C, Meleady K, Jayasinha H. Projected acute inpatient activity in New South Wales - aIM2005. Aust Health Rev. 2008 Aug; 32(3):528-36. PMID: 18666882.
    View in: PubMed
  11. Dibbens LM, Tarpey PS, Hynes K, Bayly MA, Scheffer IE, Smith R, Bomar J, Sutton E, Vandeleur L, Shoubridge C, Edkins S, Turner SJ, Stevens C, O'Meara S, Tofts C, Barthorpe S, Buck G, Cole J, Halliday K, Jones D, Lee R, Madison M, Mironenko T, Varian J, West S, Widaa S, Wray P, Teague J, Dicks E, Butler A, Menzies A, Jenkinson A, Shepherd R, Gusella JF, Afawi Z, Mazarib A, Neufeld MY, Kivity S, Lev D, Lerman-Sagie T, Korczyn AD, Derry CP, Sutherland GR, Friend K, Shaw M, Corbett M, Kim HG, Geschwind DH, Thomas P, Haan E, Ryan S, McKee S, Berkovic SF, Futreal PA, Stratton MR, Mulley JC, Gécz J. X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. Nat Genet. 2008 Jun; 40(6):776-81. PMID: 18469813.
    View in: PubMed
  12. Vaishnav AG, Pettigrew LC, Ryan S. Telephonic guidance of systemic thrombolysis in acute ischemic stroke: safety outcome in rural hospitals. Clin Neurol Neurosurg. 2008 May; 110(5):451-4. PMID: 18353532.
    View in: PubMed
  13. Agrawal RN, He S, Spee C, Cui JZ, Ryan SJ, Hinton DR. In vivo models of proliferative vitreoretinopathy. Nat Protoc. 2007; 2(1):67-77. PMID: 17401340.
    View in: PubMed
  14. He S, Incardona F, Jin M, Ryan SJ, Hinton DR. Thrombospondin-1 expression in RPE and choroidal neovascular membranes. Yan Ke Xue Bao. 2006 Dec; 22(4):265-74. PMID: 17378161.
    View in: PubMed
  15. Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR. Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochem Biophys Res Commun. 2006 Aug 11; 346(4):1200-6. PMID: 16793007.
    View in: PubMed
  16. Hoffmann S, He S, Ehren M, Ryan SJ, Wiedemann P, Hinton DR. MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes. Retina. 2006 Apr; 26(4):454-61. PMID: 16603966.
    View in: PubMed
  17. Ryan SJ. National and international patient networks: standardization of phenotype and genotype definitions. Retina. 2005 Dec; 25(8 Suppl):S68. PMID: 16374345.
    View in: PubMed
  18. Ryan SJ. Governmental, university, pharmaceutical, and foundation partnerships to advance translational research in retinal disease. Retina. 2005 Dec; 25(8 Suppl):S82. PMID: 16374353.
    View in: PubMed
  19. Hangai M, He S, Hoffmann S, Lim JI, Ryan SJ, Hinton DR. Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol. 2006 Feb; 171(1-2):45-56. PMID: 16288810.
    View in: PubMed
  20. Sreekumar PG, Kannan R, Yaung J, Spee CK, Ryan SJ, Hinton DR. Protection from oxidative stress by methionine sulfoxide reductases in RPE cells. Biochem Biophys Res Commun. 2005 Aug 19; 334(1):245-53. PMID: 15993845.
    View in: PubMed
  21. Zhou J, Pham L, Zhang N, He S, Gamulescu MA, Spee C, Ryan SJ, Hinton DR. Neutrophils promote experimental choroidal neovascularization. Mol Vis. 2005; 11:414-24. PMID: 15988410.
    View in: PubMed
  22. Chan CK, Pham LN, Zhou J, Spee C, Ryan SJ, Hinton DR. Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization. Lab Invest. 2005 Jun; 85(6):721-33. PMID: 15856049.
    View in: PubMed
  23. Smith CD, Ryan SJ, Hoover SL, Baumann RJ. Magnetic resonance imaging of the brain in Aicardi's syndrome. Report of 20 patients. J Neuroimaging. 1996 Oct; 6(4):214-21. PMID: 8903072.
    View in: PubMed
  24. Ryan SJ. The illness of Saint Fina. J Child Neurol. 1996 May; 11(3):258. PMID: 8734038.
    View in: PubMed
  25. Ryan SJ, Pettigrew LC. Cranial arteriopathy in familial Vogt-Koyanagi-Harada syndrome. J Neuroimaging. 1995 Oct; 5(4):244-5. PMID: 7579754.
    View in: PubMed
  26. Ryan SJ, Smith CD, Slevin JT. Magnetic resonance imaging in ochronosis, a rare cause of back pain. J Neuroimaging. 1994 Jan; 4(1):41-2. PMID: 8136578.
    View in: PubMed