L. Creed Pettigrew Jr., MD, MPH

Clinical interests

  • Adult Neurology
  • Cerebrovascular Disease
  • Neurosonology
  • Stroke
  • Transient Ischemic Attack (TIA)
  • Vascular Neurology

L. Creed Pettigrew Jr., MD, MPH


My name is L. Creed Pettigrew; I received my medical degree at the University of Texas Medical School, Galveston. I completed a fellowship at the University of Texas Health Science Center, Houston.

I am board certified by the American Board of Psychiatry and Neurology in Vascular Neurology and Neurology.

Faculty rank

Professor of Neurology


University of Texas Medical School, Galveston

University of Texas, Health Science Center at Houston

University of Texas Health Science Center, Houston

Certifications or Special training
American Board of Psychiatry and Neurology, Neurology
American Board of Psychiatry and Neurology, Vascular Neurology


Kentucky Neuroscience Institute

Kentucky Clinic
First Floor, Wing C, Room B101
740 S. Limestone
Lexington KY 40536-0284

Call 859-323-5661
Fax 859-323-3753

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  1. Pettigrew LC, Kryscio RJ, Norris CM. The TNFα-Transgenic Rat: Hippocampal Synaptic Integrity, Cognition, Function, and Post-Ischemic Cell Loss. PLoS One. 2016;11(5):e0154721.
    View in: PubMed
  2. Lahoti S, Gokhale S, Caplan L, Michel P, Samson Y, Rosso C, Limaye K, Hinduja A, Singhal A, Ali S, Pettigrew LC, Kryscio R, Dedhia N, Hastak S, Liebeskind DS. Thrombolysis in ischemic stroke without arterial occlusion at presentation. Stroke. 2014 Sep;45(9):2722-7.
    View in: PubMed
  3. Elkind MS, Luna JM, McClure LA, Zhang Y, Coffey CS, Roldan A, Del Brutto OH, Pretell EJ, Pettigrew LC, Meyer BC, Tapia J, White C, Benavente OR. C-reactive protein as a prognostic marker after lacunar stroke: levels of inflammatory markers in the treatment of stroke study. Stroke. 2014 Mar;45(3):707-16.
    View in: PubMed
  4. Blonder LX, Pettigrew LC, Kryscio RJ. Emotion recognition and marital satisfaction in stroke. J Clin Exp Neuropsychol. 2012; 34(6):634-42. PMID: 22439916.
    View in: PubMed
  5. Switzer JA, Hess DC, Ergul A, Waller JL, Machado LS, Portik-Dobos V, Pettigrew LC, Clark WM, Fagan SC. Matrix metalloproteinase-9 in an exploratory trial of intravenous minocycline for acute ischemic stroke. Stroke. 2011 Sep; 42(9):2633-5. PMID: 21737808.
    View in: PubMed
  6. Pandya JD, Sullivan PG, Pettigrew LC. Focal cerebral ischemia and mitochondrial dysfunction in the TNFa-transgenic rat. Brain Res. 2011 Apr 12; 1384:151-60. PMID: 21300036.
    View in: PubMed
  7. Fagan SC, Waller JL, Nichols FT, Edwards DJ, Pettigrew LC, Clark WM, Hall CE, Switzer JA, Ergul A, Hess DC. Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study. Stroke. 2010 Oct; 41(10):2283-7. PMID: 20705929.
    View in: PubMed
  8. Pettigrew LC, Kindy MS, Scheff S, Springer JE, Kryscio RJ, Li Y, Grass DS. Focal cerebral ischemia in the TNFalpha-transgenic rat. J Neuroinflammation. 2008; 5:47. PMID: 18947406.
    View in: PubMed
  9. Vaishnav AG, Pettigrew LC, Ryan S. Telephonic guidance of systemic thrombolysis in acute ischemic stroke: safety outcome in rural hospitals. Clin Neurol Neurosurg. 2008 May; 110(5):451-4. PMID: 18353532.
    View in: PubMed
  10. Espinosa PS, Pettigrew LC, Berger JR. Hereditary hemorrhagic telangectasia and spinal cord infarct: case report with a review of the neurological complications of HHT. Clin Neurol Neurosurg. 2008 May; 110(5):484-91. PMID: 18304727.
    View in: PubMed
  11. Pettigrew LC, Bang H, Chambless LE, Howard VJ, Toole JF. Assessment of pre- and post-methionine load homocysteine for prediction of recurrent stroke and coronary artery disease in the Vitamin Intervention for Stroke Prevention Trial. Atherosclerosis. 2008 Oct; 200(2):345-9. PMID: 18166191.
    View in: PubMed
  12. Korde AS, Pettigrew LC, Craddock SD, Pocernich CB, Waldmeier PC, Maragos WF. Protective effects of NIM811 in transient focal cerebral ischemia suggest involvement of the mitochondrial permeability transition. J Neurotrauma. 2007 May; 24(5):895-908. PMID: 17518543.
    View in: PubMed
  13. Ishibashi H, Pettigrew LC, Funakoshi Y, Hiramatsu M. Pharmacokinetics of arundic acid, an astrocyte modulating agent, in acute ischemic stroke. J Clin Pharmacol. 2007 Apr; 47(4):445-52. PMID: 17389553.
    View in: PubMed
  14. Blonder LX, Langer SL, Pettigrew LC, Garrity TF. The effects of stroke disability on spousal caregivers. NeuroRehabilitation. 2007; 22(2):85-92. PMID: 17656832.
    View in: PubMed
  15. Pettigrew LC, Kasner SE, Gorman M, Atkinson RP, Funakoshi Y, Ishibashi H. Effect of arundic acid on serum S-100beta in ischemic stroke. J Neurol Sci. 2006 Dec 21; 251(1-2):57-61. PMID: 17092520.
    View in: PubMed
  16. Pettigrew LC, Kasner SE, Albers GW, Gorman M, Grotta JC, Sherman DG, Funakoshi Y, Ishibashi H. Safety and tolerability of arundic acid in acute ischemic stroke. J Neurol Sci. 2006 Dec 21; 251(1-2):50-6. PMID: 17095018.
    View in: PubMed
  17. Korde AS, Pettigrew LC, Craddock SD, Maragos WF. The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia. J Neurochem. 2005 Sep; 94(6):1676-84. PMID: 16045446.
    View in: PubMed
  18. Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, Sides EG, Wang CH, Stampfer M. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004 Feb 4; 291(5):565-75. PMID: 14762035.
    View in: PubMed
  19. Robertson WC, Pettigrew LC. "Congenital" Horner's syndrome and carotid dissection. J Neuroimaging. 2003 Oct; 13(4):367-70. PMID: 14569832.
    View in: PubMed
  20. Wechsler LR, Roberts R, Furlan AJ, Higashida RT, Dillon W, Roberts H, Rowley HA, Pettigrew LC, Callahan AS, Bruno A, Fayad P, Smith WS, Firszt CM, Schulz GA. Factors influencing outcome and treatment effect in PROACT II. Stroke. 2003 May; 34(5):1224-9. PMID: 12677011.
    View in: PubMed
  21. Pettigrew LC, Holtz ML, Minger SL, Craddock SD. Glutamate receptor antagonists modulate heat shock protein response in focal brain ischemia. Neurol Res. 2003 Mar; 25(2):201-7. PMID: 12635523.
    View in: PubMed
  22. Pettigrew LC, Williams SC. Antithrombotic drugs for prevention of recurrent stroke. J Ky Med Assoc. 2002 May; 100(5):184-93. PMID: 12040909.
    View in: PubMed