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Vivek M. Rangnekar, PhD

Cancer Center Member
Markey Research Programs:
    Cancer Cell Biology and Signaling

Associate Director of Transdisciplinary Collaboration and Co-Leader, Cancer Cell Biology and Signaling Research Program

Alfred Cohen, MD, Chair in Oncology Research

Department of Radiation Medicine
College of Medicine

Research Focus

Cancer cell and molecular biology, cell signaling and apoptosis in prostate and lung cancer.

To learn more, visit Dr. Rangnekar's faculty homepage.

Contact Information

309 Combs Building
University of Kentucky
Lexington, Kentucky 40536

Key Publications

  1. Shukla N, Hebbar N and Rangnekar VM. Par-4 in prostate cancer in Prostate Cancer: Biochemistry, Molecular Biology and Genetics (Springer Science) Editor Don Tindall (Mayo Clinic). Invited book Chapter (in press), 2012.
  2. Rangnekar VM and Mattson MP. Pivotal role of the leucine zipper domain protein Par-4 in neuronal cell apoptosis: in Recent Research Developments in Neurochemistry (Research Signpost, Trivandrum). Volume 3, 125-134, 2000.
  3. Rangnekar VM. Apoptosis by Par-4 protein. Programmed Cell Death: Cellular and Molecular Mechanisms. (Elsevier Science, Inc., NY). Editors: M. P. Mattson, S. Estus, and V. M. Rangnekar. Volume 1, 215-236, 2001.

Five Most Recent Publications (an automated list via PubMed, based on researcher's ID and University of Kentucky)

1.  Liu Y, Gilbert MR, Kyprianou N, Rangnekar VM, Horbinski C.
The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.
Acta Neuropathol. 2014 Nov;128(5):723-32.
2.  Burikhanov R, Sviripa VM, Hebbar N, Zhang W, Layton WJ, Hamza A, Zhan CG, Watt DS, Liu C, Rangnekar VM.
Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis.
Nat Chem Biol. 2014 Nov;10(11):924-6.
3.  Chen X, Sahasrabuddhe AA, Szankasi P, Chung F, Basrur V, Rangnekar VM, Pagano M, Lim MS, Elenitoba-Johnson KS.
Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.
Cell Death Differ. 2014 Oct;21(10):1535-45.
4.  Burikhanov R, Shrestha-Bhattarai T, Hebbar N, Qiu S, Zhao Y, Zambetti GP, Rangnekar VM.
Paracrine apoptotic effect of p53 mediated by tumor suppressor Par-4.
Cell Rep. 2014 Jan;6(2):271-7.
5.  de Thonel A, Hazoumé A, Kochin V, Isoniemi K, Jego G, Fourmaux E, Hammann A, Mjahed H, Filhol O, Micheau O, Rocchi P, Mezger V, Eriksson JE, Rangnekar VM, Garrido C.
Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.
Cell Death Dis. 2014;5:e1016.