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smyth-susan

Susan S. Smyth, MD, PhD, FACC

Chief, Division of Cardiovascular Medicine
Medical Director, Gill Heart Institute

Practice areas

  • Cardiac Intensive Care
  • Cardiovascular Medicine
  • Women’s Heart Health

Faculty rank

Professor of Medicine

Clinic information

Clinical interests

  • Acute Coronary Syndromes
  • Antithrombotic Therapy
  • Cardiovascular Disease
  • General Cardiology
  • Ischemic Vascular Disease
  • Platelet and Vascular Biology
  • Thrombosis
  • Translational Cardiovascular Medicine

Education

Degree

University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill

Residency

University Medical Center, Stony Brook, N.Y.

Fellowship

University of North Carolina at Chapel Hill, Chapel Hill
Mt. Sinai Medical School, New York

Certifications or Special training

American Board of Internal Medicine, Cardiovascular Disease
Fellow of the American College of Cardiology

Additional information

Profile

My name is Susan Smyth; I received my medical degree from University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, N.C. I then completed fellowships at Mt. Sinai Medical School, New York, and University of North Carolina, Chapel Hill, N.C .

I am board certified by the American Board of Internal Medicine in Cardiovascular Disease and a Fellow of the American College of Cardiology.

Research/Publications

  1. Sexton T, Wallace EL, Smyth SS. Anti-Thrombotic Effects of Statins in Acute Coronary Syndromes: At the Intersection of Thrombosis, Inflammation, and Platelet-Leukocyte Interactions. Curr Cardiol Rev. 2016 May 3.
    View in: PubMed
  2. Sexton TR, Wallace EL, Chen A, Charnigo RJ, Reda HK, Ziada KM, Gurley JC, Smyth SS. Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement. J Thromb Thrombolysis. 2016 Apr;41(3):384-93.
    View in: PubMed
  3. Xiang B, Zhang G, Ye S, Zhang R, Huang C, Liu J, Tao M, Ruan C, Smyth SS, Whiteheart SW, Li Z. Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis. Circulation. 2015 Dec 15;132(24):2334-44.
    View in: PubMed
  4. Klyachkin YM, Nagareddy PR, Ye S, Wysoczynski M, Asfour A, Gao E, Sunkara M, Brandon JA, Annabathula R, Ponnapureddy R, Solanki M, Pervaiz ZH, Smyth SS, Ratajczak MZ, Morris AJ, Abdel-Latif A. Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction. Stem Cells Transl Med. 2015 Nov;4(11):1333-43.
    View in: PubMed
  5. Beavers CJ, Heron P, Smyth SS, Bain JA, Macaulay TE. Obesity and Antiplatelets-Does One Size Fit All? Thromb Res. 2015 Oct;136(4):712-6.
    View in: PubMed
  6. Gross AK, Dunn SP, Feola DJ, Martin CA, Charnigo R, Li Z, Abdel-Latif A, Smyth SS. Clopidogrel treatment and the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and critical illness. J Thromb Thrombolysis. 2013 Feb; 35(2):147-54. PMID: 23124575.
    View in: PubMed
  7. Xiang B, Zhang G, Ren H, Sunkara M, Morris AJ, Gartner TK, Smyth SS, Li Z. The P2Y(12) Antagonists, 2MeSAMP and Cangrelor, Inhibit Platelet Activation through P2Y(12)/G(i)-Dependent Mechanism. PLoS One. 2012; 7(12):e51037. PMID: 23236426.
    View in: PubMed
  8. Wallace EL, Smyth SS. Spontaneous coronary thrombosis following thrombolytic therapy for acute cardiovascular accident and stroke: a case study. J Thromb Thrombolysis. 2012 Nov; 34(4):548-51. PMID: 22684577.
    View in: PubMed
  9. Panchatcharam M, Miriyala S, Salous A, Wheeler J, Dong A, Mueller P, Sunkara M, Escalante-Alcalde D, Morris AJ, Smyth SS. Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia. Arterioscler Thromb Vasc Biol. 2013 Jan; 33(1):52-9. PMID: 23104851.
    View in: PubMed
  10. Yang F, Dong A, Mueller P, Caicedo J, Sutton AM, Odetunde J, Barrick CJ, Klyachkin YM, Abdel-Latif A, Smyth SS. Coronary artery remodeling in a model of left ventricular pressure overload is influenced by platelets and inflammatory cells. PLoS One. 2012; 7(8):e40196. PMID: 22916095.
    View in: PubMed
  11. Dong A, Sunkara M, Panchatcharam M, Salous A, Selim S, Morris AJ, Smyth SS. Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury. Adv Hematol. 2012; 2012:924042. PMID: 22919395.
    View in: PubMed
  12. Ren H, Panchatcharam M, Mueller P, Escalante-Alcalde D, Morris AJ, Smyth SS. Lipid phosphate phosphatase (LPP3) and vascular development. Biochim Biophys Acta. 2013 Jan; 1831(1):126-32. PMID: 22835522.
    View in: PubMed
  13. Becker RC, Smyth S. Biomarker science: on a theme of personalized medicine. J Thromb Thrombolysis. 2012 Jul; 34(1):141-2. PMID: 22528327.
    View in: PubMed
  14. Abdel-Latif A, Smyth SS. Preventing platelet thrombosis with a PAR1 pepducin. Circulation. 2012 Jul 3; 126(1):13-5. PMID: 22705888.
    View in: PubMed
  15. Bailey AL, Smyth SS. Invasive coronary vasoreactivity testing to diagnose microvascular dysfunction in women. JACC Cardiovasc Interv. 2012 Jun; 5(6):654-5. PMID: 22721661.
    View in: PubMed
  16. Federico L, Ren H, Mueller PA, Wu T, Liu S, Popovic J, Blalock EM, Sunkara M, Ovaa H, Albers HM, Mills GB, Morris AJ, Smyth SS. Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. Mol Endocrinol. 2012 May; 26(5):786-97. PMID: 22474126.
    View in: PubMed
  17. Rowley JW, Finn AV, French PA, Jennings LK, Bluestein D, Gross PL, Freedman JE, Steinhubl SR, Zimmerman GA, Becker RC, Dauerman HL, Smyth SS. Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses. Circ Cardiovasc Interv. 2012 Apr; 5(2):296-304. PMID: 22511738.
    View in: PubMed
  18. Wang TY, Angiolillo DJ, Cushman M, Sabatine MS, Bray PF, Smyth SS, Dauerman HL, French PA, Becker RC. Platelet biology and response to antiplatelet therapy in women: implications for the development and use of antiplatelet pharmacotherapies for cardiovascular disease. J Am Coll Cardiol. 2012 Mar 6; 59(10):891-900. PMID: 22381424.
    View in: PubMed
  19. Selim S, Sunkara M, Salous AK, Leung SW, Berdyshev EV, Bailey A, Campbell CL, Charnigo R, Morris AJ, Smyth SS. Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. Clin Sci (Lond). 2011 Dec; 121(12):565-72. PMID: 21749329.
    View in: PubMed
  20. Granada JF, Price MJ, French PA, Steinhubl SR, Cutlip DE, Becker RC, Smyth SS, Dauerman HL. Platelet-mediated thrombosis and drug-eluting stents. Circ Cardiovasc Interv. 2011 Dec 1; 4(6):629-37. PMID: 22186107.
    View in: PubMed
  21. Smyth SS. Anti-platelet therapy. Curr Drug Targets. 2011 Nov; 12(12):1790-1. PMID: 21718241.
    View in: PubMed
  22. Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(1):24-32. PMID: 22015657.
    View in: PubMed
  23. Zhao J, He D, Berdyshev E, Zhong M, Salgia R, Morris AJ, Smyth SS, Natarajan V, Zhao Y. Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways. Biochem J. 2011 Oct 1; 439(1):45-55. PMID: 21696367.
    View in: PubMed
  24. Zhang G, Xiang B, Ye S, Chrzanowska-Wodnicka M, Morris AJ, Gartner TK, Whiteheart SW, White GC, Smyth SS, Li Z. Distinct roles for Rap1b protein in platelet secretion and integrin aIIbß3 outside-in signaling. J Biol Chem. 2011 Nov 11; 286(45):39466-77. PMID: 21940635.
    View in: PubMed
  25. Li Z, Smyth SS. Connexin 37 counteracts clotting. Circulation. 2011 Aug 23; 124(8):873-5. PMID: 21859981.
    View in: PubMed
  26. Song Z, Jin R, Yu S, Rivet JJ, Smyth SS, Nanda A, Granger DN, Li G. CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury. PLoS One. 2011; 6(8):e23239. PMID: 21876738.
    View in: PubMed
  27. Fulkerson Z, Wu T, Sunkara M, Kooi CV, Morris AJ, Smyth SS. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J Biol Chem. 2011 Oct 7; 286(40):34654-63. PMID: 21832043.
    View in: PubMed
  28. Zhang G, Xiang B, Dong A, Skoda RC, Daugherty A, Smyth SS, Du X, Li Z. Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood. 2011 Sep 29; 118(13):3670-9. PMID: 21803853.
    View in: PubMed
  29. Bailey AL, Smyth SS, Campbell CL. The case against routine aspirin use for primary prevention in low-risk adults. Am Fam Physician. 2011 Jun 15; 83(12):1387-90. PMID: 21671539.
    View in: PubMed
  30. Campbell CL, Steinhubl SR, Hooper WC, Jozic J, Smyth SS, Bernstein D, De Staercke C, Syros G, Negus BH, Stuckey T, Stone GW, Mehran R, Dangas G. Bleeding events are associated with an increase in markers of inflammation in acute coronary syndromes: an ACUITY trial substudy. J Thromb Thrombolysis. 2011 Feb; 31(2):139-45. PMID: 20872045.
    View in: PubMed
  31. Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A. Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol. 2011 Feb; 18(2):198-204. PMID: 21240271.
    View in: PubMed
  32. Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, Parise LV, Dauerman HL, French PA, Smyth SS, Becker RC. Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2372-84. PMID: 21084706.
    View in: PubMed
  33. Smyth SS. Platelets unplugged: an ATVB special series focused on platelet biology. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2339-40. PMID: 21084705.
    View in: PubMed
  34. Li Z, Yang F, Dunn S, Gross AK, Smyth SS. Platelets as immune mediators: their role in host defense responses and sepsis. Thromb Res. 2011 Mar; 127(3):184-8. PMID: 21075430.
    View in: PubMed
  35. Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, Li Z. A G(i) -independent mechanism mediating Akt phosphorylation in platelets. J Thromb Haemost. 2010 Sep; 8(9):2032-41. PMID: 20586915.
    View in: PubMed
  36. Abdel-Latif A, Zuba-Surma EK, Ziada KM, Kucia M, Cohen DA, Kaplan AM, Van Zant G, Selim S, Smyth SS, Ratajczak MZ. Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia. Exp Hematol. 2010 Dec; 38(12):1131-1142.e1. PMID: 20800644.
    View in: PubMed
  37. Ren H, Federico L, Huang H, Sunkara M, Drennan T, Frohman MA, Smyth SS, Morris AJ. A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis. Mol Biol Cell. 2010 Sep 15; 21(18):3171-81. PMID: 20660155.
    View in: PubMed
  38. Dong A, Caicedo J, Han SG, Mueller P, Saha S, Smyth SS, Gairola CG. Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism. Thromb Res. 2010 Oct; 126(4):e312-7. PMID: 20451958.
    View in: PubMed
  39. Dauerman HL, Bhatt DL, Gretler DD, French PA, Smyth SS, Becker RC. Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients. Am Heart J. 2010 Apr; 159(4):508-517.e1. PMID: 20362707.
    View in: PubMed
  40. Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, Schuurman K, van Tellingen O, Morris AJ, Smyth SS, Moolenaar WH, Ovaa H. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7257-62. PMID: 20360563.
    View in: PubMed
  41. Im E, Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S, Kazlauskas A. Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. Mol Cell Biol. 2010 May; 30(10):2401-10. PMID: 20231358.
    View in: PubMed
  42. Panchatcharam M, Miriyala S, Yang F, Leitges M, Chrzanowska-Wodnicka M, Quilliam LA, Anaya P, Morris AJ, Smyth SS. Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. Int J Biochem Cell Biol. 2010 Jun; 42(6):965-74. PMID: 20184965.
    View in: PubMed
  43. Miriyala S, Subramanian T, Panchatcharam M, Ren H, McDermott MI, Sunkara M, Drennan T, Smyth SS, Spielmann HP, Morris AJ. Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. J Biol Chem. 2010 Apr 30; 285(18):13918-29. PMID: 20110354.
    View in: PubMed
  44. Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, French PA, Dauerman HL, Becker RC. Platelet functions beyond hemostasis. J Thromb Haemost. 2009 Nov; 7(11):1759-66. PMID: 19691483.
    View in: PubMed
  45. Li G, Jin R, Norris RA, Zhang L, Yu S, Wu F, Markwald RR, Nanda A, Conway SJ, Smyth SS, Granger DN. Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway. Atherosclerosis. 2010 Feb; 208(2):358-65. PMID: 19695571.
    View in: PubMed
  46. Becker RC, Smyth S. The evolution of platelet-directed pharmacotherapy. J Thromb Haemost. 2009 Jul; 7 Suppl 1:266-71. PMID: 19630814.
    View in: PubMed
  47. Morris AJ, Panchatcharam M, Cheng HY, Federico L, Fulkerson Z, Selim S, Miriyala S, Escalante-Alcalde D, Smyth SS. Regulation of blood and vascular cell function by bioactive lysophospholipids. J Thromb Haemost. 2009 Jul; 7 Suppl 1:38-43. PMID: 19630765.
    View in: PubMed
  48. Barrick CJ, Dong A, Waikel R, Corn D, Yang F, Threadgill DW, Smyth SS. Parent-of-origin effects on cardiac response to pressure overload in mice. Am J Physiol Heart Circ Physiol. 2009 Sep; 297(3):H1003-9. PMID: 19561308.
    View in: PubMed
  49. Barrick CJ, Roberts RB, Rojas M, Rajamannan NM, Suitt CB, O'Brien KD, Smyth SS, Threadgill DW. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H65-75. PMID: 19448146.
    View in: PubMed
  50. Oestreich JH, Holt J, Dunn SP, Smyth SS, Campbell CL, Charnigo R, Akers WS, Steinhubl SR. Considerable variability in platelet activity among patients with coronary artery disease in response to an increased maintenance dose of clopidogrel. Coron Artery Dis. 2009 May; 20(3):207-13. PMID: 19318928.
    View in: PubMed
  51. Morris AJ, Selim S, Salous A, Smyth SS. Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation. Trends Cardiovasc Med. 2009 May; 19(4):135-40. PMID: 19818950.
    View in: PubMed
  52. Zanotti G, Casiraghi M, Abano JB, Tatreau JR, Sevala M, Berlin H, Smyth S, Funkhouser WK, Burridge K, Randell SH, Egan TM. Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L52-63. PMID: 19376887.
    View in: PubMed
  53. Mackman N, Smyth S. Cardiovascular disease in women. Arterioscler Thromb Vasc Biol. 2009 Mar; 29(3):277-8. PMID: 19221202.
    View in: PubMed
  54. Bailey AL, Scantlebury DC, Smyth SS. Thrombosis and antithrombotic therapy in women. Arterioscler Thromb Vasc Biol. 2009 Mar; 29(3):284-8. PMID: 19221205.
    View in: PubMed
  55. Oestreich JH, Smyth SS, Campbell CL. Platelet function analysis: at the edge of meaning. Thromb Haemost. 2009 Feb; 101(2):217-9. PMID: 19190799.
    View in: PubMed
  56. Meredith D, Panchatcharam M, Miriyala S, Tsai YS, Morris AJ, Maeda N, Stouffer GA, Smyth SS. Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling. Arterioscler Thromb Vasc Biol. 2009 Apr; 29(4):465-71. PMID: 19179641.
    View in: PubMed
  57. Pamuklar Z, Federico L, Liu S, Umezu-Goto M, Dong A, Panchatcharam M, Fulkerson Z, Fulerson Z, Berdyshev E, Natarajan V, Fang X, van Meeteren LA, Moolenaar WH, Mills GB, Morris AJ, Smyth SS. Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem. 2009 Mar 13; 284(11):7385-94. PMID: 19139100.
    View in: PubMed
  58. Smyth SS, Woulfe DS, Weitz JI, Gachet C, Conley PB, Goodman SG, Roe MT, Kuliopulos A, Moliterno DJ, French PA, Steinhubl SR, Becker RC. G-protein-coupled receptors as signaling targets for antiplatelet therapy. Arterioscler Thromb Vasc Biol. 2009 Apr; 29(4):449-57. PMID: 19023091.
    View in: PubMed
  59. Panchatcharam M, Miriyala S, Yang F, Rojas M, End C, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circ Res. 2008 Sep 12; 103(6):662-70. PMID: 18703779.
    View in: PubMed
  60. Federico L, Pamuklar Z, Smyth SS, Morris AJ. Therapeutic potential of autotaxin/lysophospholipase d inhibitors. Curr Drug Targets. 2008 Aug; 9(8):698-708. PMID: 18691016.
    View in: PubMed
  61. Smyth SS, Cheng HY, Miriyala S, Panchatcharam M, Morris AJ. Roles of lysophosphatidic acid in cardiovascular physiology and disease. Biochim Biophys Acta. 2008 Sep; 1781(9):563-70. PMID: 18586114.
    View in: PubMed
  62. Smyth S. MRSA carriage. Br J Gen Pract. 2008 Feb; 58(547):125. PMID: 18307858.
    View in: PubMed
  63. Pamuklar Z, Lee JS, Cheng HY, Panchatcharam M, Steinhubl S, Morris AJ, Charnigo R, Smyth SS. Individual heterogeneity in platelet response to lysophosphatidic acid: evidence for a novel inhibitory pathway. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):555-61. PMID: 18202325.
    View in: PubMed
  64. Smyth SS, Monroe DM, Wysokinski WE, McBane RD, Whiteheart SW, Becker RC, Steinhubl SR. Platelet activation and its patient-specific consequences. Thromb Res. 2008; 122(4):435-41. PMID: 17949794.
    View in: PubMed
  65. Stansfield WE, Rojas M, Corn D, Willis M, Patterson C, Smyth SS, Selzman CH. Characterization of a model to independently study regression of ventricular hypertrophy. J Surg Res. 2007 Oct; 142(2):387-93. PMID: 17574596.
    View in: PubMed
  66. Li G, Keenan AC, Young JC, Hall MJ, Pamuklar Z, Ohman EM, Steinhubl SR, Smyth SS. Effects of unfractionated heparin and glycoprotein IIb/IIIa antagonists versus bivalirdin on myeloperoxidase release from neutrophils. Arterioscler Thromb Vasc Biol. 2007 Aug; 27(8):1850-6. PMID: 17525363.
    View in: PubMed
  67. Campbell CL, Smyth S, Montalescot G, Steinhubl SR. Aspirin dose for the prevention of cardiovascular disease: a systematic review. JAMA. 2007 May 9; 297(18):2018-24. PMID: 17488967.
    View in: PubMed
  68. Dorsch MP, Lee JS, Lynch DR, Dunn SP, Rodgers JE, Schwartz T, Colby E, Montague D, Smyth SS. Aspirin resistance in patients with stable coronary artery disease with and without a history of myocardial infarction. Ann Pharmacother. 2007 May; 41(5):737-41. PMID: 17456544.
    View in: PubMed
  69. Lee JS, Dunn SP, Marshall HM, Cohen MG, Smyth SS. A case report of simultaneous thrombosis of two coronary artery stents in association with clopidogrel resistance. Clin Cardiol. 2007 Apr; 30(4):200-3. PMID: 17443655.
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  70. Matsuo O, Lijnen HR, Ueshima S, Kojima S, Smyth SS. A guide to murine fibrinolytic factor structure, function, assays, and genetic alterations. J Thromb Haemost. 2007 Apr; 5(4):680-9. PMID: 17403202.
    View in: PubMed
  71. Emeis JJ, Jirouskova M, Muchitsch EM, Shet AS, Smyth SS, Johnson GJ. A guide to murine coagulation factor structure, function, assays, and genetic alterations. J Thromb Haemost. 2007 Apr; 5(4):670-9. PMID: 17403201.
    View in: PubMed
  72. Morris AJ, Smyth SS. Measurement of autotaxin/lysophospholipase D activity. Methods Enzymol. 2007; 434:89-104. PMID: 17954243.
    View in: PubMed
  73. Barrick CJ, Rojas M, Schoonhoven R, Smyth SS, Threadgill DW. Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2007 May; 292(5):H2119-30. PMID: 17172276.
    View in: PubMed
  74. Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell'elba G, Pecce R, Martelli N, Federico L, Rojas M, Berton G, Lowell CA, Totani L, Smyth SS. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood. 2007 Mar 15; 109(6):2461-9. PMID: 17095622.
    View in: PubMed
  75. Liu P, Patil S, Rojas M, Fong AM, Smyth SS, Patel DD. CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):2056-62. PMID: 16809547.
    View in: PubMed
  76. Totani L, Piccoli A, Manarini S, Federico L, Pecce R, Martelli N, Cerletti C, Piccardoni P, Lowell CA, Smyth SS, Berton G, Evangelista V. Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin. Biochem J. 2006 May 15; 396(1):89-98. PMID: 16433632.
    View in: PubMed
  77. Smyth SS, Jennings JL. PPARgamma agonists: a new strategy for antithrombotic therapy. J Thromb Haemost. 2005 Oct; 3(10):2147-8. PMID: 16194191.
    View in: PubMed
  78. Armstrong D, Veldhuyzen van Zanten SJ, Barkun AN, Chiba N, Thomson AB, Smyth S, Sinclair P, Chakraborty B, White RJ. Heartburn-dominant, uninvestigated dyspepsia: a comparison of 'PPI-start' and 'H2-RA-start' management strategies in primary care--the CADET-HR Study. Aliment Pharmacol Ther. 2005 May 15; 21(10):1189-202. PMID: 15882239.
    View in: PubMed
  79. Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC. Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest. 2005 Mar; 115(3):680-7. PMID: 15696195.
    View in: PubMed
  80. Stouffer GA, Smyth SS. Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells. Arterioscler Thromb Vasc Biol. 2003 Nov 1; 23(11):1971-8. PMID: 12947018.
    View in: PubMed
  81. Smyth SS, Sciorra VA, Sigal YJ, Pamuklar Z, Wang Z, Xu Y, Prestwich GD, Morris AJ. Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. J Biol Chem. 2003 Oct 31; 278(44):43214-23. PMID: 12909631.
    View in: PubMed
  82. Sajid M, Zhao R, Pathak A, Smyth SS, Stouffer GA. Alphavbeta3-integrin antagonists inhibit thrombin-induced proliferation and focal adhesion formation in smooth muscle cells. Am J Physiol Cell Physiol. 2003 Nov; 285(5):C1330-8. PMID: 12878490.
    View in: PubMed
  83. Smyth SS. Tweezing apart von Willebrand factor-glycoprotein Ib-IX adhesive signaling. J Thromb Haemost. 2003 Jun; 1(6):1136-7. PMID: 12871308.
    View in: PubMed
  84. Evangelista V, Manarini S, Coller BS, Smyth SS. Role of P-selectin, beta2-integrins, and Src tyrosine kinases in mouse neutrophil-platelet adhesion. J Thromb Haemost. 2003 May; 1(5):1048-54. PMID: 12871376.
    View in: PubMed
  85. Smyth SS, Pathak A, Stouffer GA. In-stent restenosis: more fuel for the fire. Am Heart J. 2002 Oct; 144(4):577-9. PMID: 12360150.
    View in: PubMed
  86. Palmerini T, Nedelman MA, Scudder LE, Nakada MT, Jordan RE, Smyth S, Gordon RE, Fallon JT, Coller BS. Effects of abciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primates. J Am Coll Cardiol. 2002 Jul 17; 40(2):360-6. PMID: 12106945.
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  87. Smyth SS, Patterson C. Tiny dancers: the integrin-growth factor nexus in angiogenic signaling. J Cell Biol. 2002 Jul 8; 158(1):17-21. PMID: 12105178.
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  88. Jirousková M, Smyth SS, Kudryk B, Coller BS. A hamster antibody to the mouse fibrinogen gamma chain inhibits platelet-fibrinogen interactions and FXIIIa-mediated fibrin cross-linking, and facilitates thrombolysis. Thromb Haemost. 2001 Oct; 86(4):1047-56. PMID: 11686323.
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  89. Zhang ZG, Zhang L, Tsang W, Goussev A, Powers C, Ho KL, Morris D, Smyth SS, Coller BS, Chopp M. Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion. Brain Res. 2001 Sep 7; 912(2):181-94. PMID: 11532435.
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  90. Smyth SS, Reis ED, Väänänen H, Zhang W, Coller BS. Variable protection of beta 3-integrin--deficient mice from thrombosis initiated by different mechanisms. Blood. 2001 Aug 15; 98(4):1055-62. PMID: 11493451.
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  91. Smyth SS, Reis ED, Zhang W, Fallon JT, Gordon RE, Coller BS. Beta(3)-integrin-deficient mice but not P-selectin-deficient mice develop intimal hyperplasia after vascular injury: correlation with leukocyte recruitment to adherent platelets 1 hour after injury. Circulation. 2001 May 22; 103(20):2501-7. PMID: 11369692.
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  92. Smyth SS, Tsakiris DA, Scudder LE, Coller BS. Structure and function of murine alphaIIbbeta3 (GPIIb/IIIa): studies using monoclonal antibodies and beta3-null mice,. Thromb Haemost. 2000 Dec; 84(6):1103-8. PMID: 11154120.
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  93. Lengweiler S, Smyth SS, Jirouskova M, Scudder LE, Park H, Moran T, Coller BS. Preparation of monoclonal antibodies to murine platelet glycoprotein IIb/IIIa (alphaIIbbeta3) and other proteins from hamster-mouse interspecies hybridomas. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):167-73. PMID: 10448087.
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  94. Smyth SS, Parise LV. Regulation of ligand binding to glycoprotein IIb-IIIa (integrin alpha IIb beta 3) in isolated platelet membranes. Biochem J. 1993 Jun 15; 292 ( Pt 3):749-58. PMID: 7686366.
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  95. Smyth SS, Joneckis CC, Parise LV. Regulation of vascular integrins. Blood. 1993 Jun 1; 81(11):2827-43. PMID: 8499621.
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  96. Smyth SS, Hillery CA, Parise LV. Fibrinogen binding to purified platelet glycoprotein IIb-IIIa (integrin alpha IIb beta 3) is modulated by lipids. J Biol Chem. 1992 Aug 5; 267(22):15568-77. PMID: 1639797.
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  97. Hillery CA, Smyth SS, Parise LV. Phosphorylation of human platelet glycoprotein IIIa (GPIIIa). Dissociation from fibrinogen receptor activation and phosphorylation of GPIIIa in vitro. J Biol Chem. 1991 Aug 5; 266(22):14663-9. PMID: 1650365.
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