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John M. O'Brien Jr., MD

Chief, Division of Maternal-Fetal Medicine
Fellowship Director

Practice areas

  • Obstetrics and Gynecology, Maternal-Fetal Medicine

Faculty rank

Associate Professor of Obstetrics and Gynecology

Clinic information

Clinical interests

  • Birthing Center

Education

Degree

Wayne State University, School of Medicine, Detroit

Residency

Wayne State University, School of Medicine, Detroit

Fellowship

University of Tennessee Medical Center, Knoxville

Certifications or Special training

American Board of Obstetrics and Gynecology
American Board of Obstetrics and Gynecology, Maternal-Fetal Medicine

Additional information

Profile

My name is John O’Brien; I received my medical degree from Wayne State University, School of Medicine, Detroit. I completed a fellowship at the University of Tennessee Medical Center, Knoxville.

I am board certified by the American Board of Obstetrics and Gynecology in Maternal-Fetal Medicine.

Research/Publications

  1. O'Brien JM. Can history repeat itself? Improved assessment of the best biomarker is the first step. BJOG. 2016 May;123(6):885.
    View in: PubMed
  2. O'Brien JM, Lewis DF. Prevention of preterm birth with vaginal progesterone or 17-alpha-hydroxyprogesterone caproate: a critical examination of efficacy and safety. Am J Obstet Gynecol. 2016 Jan;214(1):45-56.
    View in: PubMed
  3. O'Brien JM. Progestogen safety in multiple gestations: application of the Bradford Hill criteria. BJOG. 2015 Apr;122(5):610-4.
    View in: PubMed
  4. Pearce CF, Lain K, Hansen WF, Curry T, O'Brien JM. The use of digital peripheral artery tonometry to detect endothelial dysfunction in pregnant women who smoke. Am J Perinatol. 2014 Feb;31(2):113-8.
    View in: PubMed
  5. O'Brien JM. Medication safety is still an issue in obstetrics 50 years after the Kefauver-Harris amendments: the case of progestogens. Ultrasound Obstet Gynecol. 2013 Sep;42(3):247-53.
    View in: PubMed
  6. Conde-Agudelo A, Romero R, Nicolaides K, Chaiworapongsa T, O'Brien JM, Cetingoz E, da Fonseca E, Creasy G, Soma-Pillay P, Fusey S, Cam C, Alfirevic Z, Hassan SS. Vaginal progesterone vs cervical cerclage for the prevention of preterm birth in women with a sonographic short cervix, previous preterm birth, and singleton gestation: a systematic review and indirect comparison metaanalysis. Am J Obstet Gynecol. 2013 Jan; 208(1):42.e1-42.e18. PMID: 23157855.
    View in: PubMed
  7. O'Brien JM. The safety of progesterone and 17-hydroxyprogesterone caproate administration for the prevention of preterm birth: an evidence-based assessment. Am J Perinatol. 2012 Oct; 29(9):665-72. PMID: 22773279.
    View in: PubMed
  8. O'Brien JM. 17a-hydroxyprogesterone caproate for the prevention of adverse neonatal outcome in multiple pregnancies: a randomized controlled trial. Obstet Gynecol. 2012 Feb; 119(2 Pt 1):384-5; author reply 385-6. PMID: 22270303.
    View in: PubMed
  9. Romero R, Nicolaides K, Conde-Agudelo A, Tabor A, O'Brien JM, Cetingoz E, Da Fonseca E, Creasy GW, Klein K, Rode L, Soma-Pillay P, Fusey S, Cam C, Alfirevic Z, Hassan SS. Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. Am J Obstet Gynecol. 2012 Feb; 206(2):124.e1-19. PMID: 22284156.
    View in: PubMed
  10. O'Brien JM, Whetham D, Fecteau C, Jansen J, Hiles M. Augmenting myometrial healing after cesarean delivery: use of an adjuvant biologic graft placement in an ovine model. Am J Perinatol. 2011 Aug; 28(7):543-50. PMID: 21365531.
    View in: PubMed
  11. O'Brien JM. 17-hydroxyprogesterone caproate, progesterone, preterm birth prevention, and safety: who decides? Someone should. Am J Obstet Gynecol. 2011 May; 204(5):e16-7; author reply e17. PMID: 21276949.
    View in: PubMed
  12. O'Brien JM, Ho SJ, Istwan NB, Stanziano GJ, Rhea DJ, Barton JR. Uterine activity in women receiving 17 alpha-hydroxyprogesterone caproate for the prevention of preterm birth: an observational study. Am J Perinatol. 2010 Feb; 27(2):157-62. PMID: 19644788.
    View in: PubMed
  13. O'Brien JM, Lewis DF. Progestins for the prevention of spontaneous preterm birth: review and implications of recent studies. J Reprod Med. 2009 Feb; 54(2):73-87. PMID: 19301570.
    View in: PubMed
  14. Stella CL, O'Brien JM, Forrester KJ, Barton JR, Istwan N, Rhea D, Sibai BM. The coexistence of gestational hypertension and diabetes: influence on pregnancy outcome. Am J Perinatol. 2008 Jun; 25(6):325-9. PMID: 18493883.
    View in: PubMed
  15. O'Brien JM. Progesterone and preterm birth. N Engl J Med. 2007 Nov 29; 357(22):2306; author reply 2307. PMID: 18050514.
    View in: PubMed
  16. Nelson WL, O'Brien JM. The uterine sandwich for persistent uterine atony: combining the B-Lynch compression suture and an intrauterine Bakri balloon. Am J Obstet Gynecol. 2007 May; 196(5):e9-10. PMID: 17466689.
    View in: PubMed
  17. O'Brien JM. Placenta previa, placenta accreta, and vasa previa. Obstet Gynecol. 2007 Jan; 109(1):203-4; author reply 204. PMID: 17197611.
    View in: PubMed
  18. O'Brien JM. Management of cervical insufficiency and bulging fetal membranes. Obstet Gynecol. 2006 Jun; 107(6):1421-2; author reply 1422. PMID: 16738177.
    View in: PubMed
  19. O'Brien JM. Dexamethasone, HELLP syndrome, and study design. Am J Obstet Gynecol. 2006 Dec; 195(6):e13-4; author reply e15-7. PMID: 16677590.
    View in: PubMed
  20. Day MC, Barton JR, O'Brien JM, Istwan NB, Sibai BM. The effect of fetal number on the development of hypertensive conditions of pregnancy. Obstet Gynecol. 2005 Nov; 106(5 Pt 1):927-31. PMID: 16260508.
    View in: PubMed
  21. O'Brien JM, Barton JR. Controversies with the diagnosis and management of HELLP syndrome. Clin Obstet Gynecol. 2005 Jun; 48(2):460-77. PMID: 15805802.
    View in: PubMed
  22. Schwendemann WD, O'Brien JM, Barton JR, Milligan DA, Istwan N. Modifiable risk factors for growth restriction in twin pregnancies. Am J Obstet Gynecol. 2005 May; 192(5):1440-2. PMID: 15902131.
    View in: PubMed
  23. Lombardi DG, Barton JR, O'Brien JM, Istwan NK, Sibai BM. Does an obese prepregnancy body mass index influence outcome in pregnancies complicated by mild gestational hypertension remote from term? Am J Obstet Gynecol. 2005 May; 192(5):1472-4. PMID: 15902141.
    View in: PubMed
  24. Lombardi DG, Istwan NB, Rhea DJ, O'Brien JM, Barton JR. Measuring outpatient outcomes of emesis and nausea management in pregnant women. Manag Care. 2004 Nov; 13(11):48-52. PMID: 15595402.
    View in: PubMed
  25. Cottrill HM, Barton JR, O'brien JM, Rhea DL, Milligan DA. Factors influencing maternal perception of uterine contractions. Am J Obstet Gynecol. 2004 May; 190(5):1455-7. PMID: 15167867.
    View in: PubMed
  26. Moldenhauer JS, O'brien JM, Barton JR, Sibai B. Acute fatty liver of pregnancy associated with pancreatitis: a life-threatening complication. Am J Obstet Gynecol. 2004 Feb; 190(2):502-5. PMID: 14981397.
    View in: PubMed
  27. O'Brien JM, Barton JR, Milligan DA. An aggressive interventional protocol for early midtrimester premature rupture of the membranes using gelatin sponge for cervical plugging. Am J Obstet Gynecol. 2002 Nov; 187(5):1143-6. PMID: 12439492.
    View in: PubMed
  28. Barton CB, Barton JR, O'Brien JM, Bergauer NK, Sibai BM. Mild gestational hypertension: differences in ethnicity are associated with altered outcomes in women who undergo outpatient treatment. Am J Obstet Gynecol. 2002 May; 186(5):896-8. PMID: 12015506.
    View in: PubMed
  29. O'Brien JM, Milligan DA, Barton JR. Gelatin sponge embolization. a method for the management of iatrogenic preterm premature rupture of the membranes. Fetal Diagn Ther. 2002 Jan-Feb; 17(1):8-10. PMID: 11803208.
    View in: PubMed