UK HealthCare logo

Practice areas

  • ALS - Amyotrophic Lateral Sclerosis
  • Neurology
  • Neuromuscular Disease

Faculty rank

Professor of Neurology

Clinic information

Clinical interests

  • Amyotrophic Lateral Sclerosis (ALS)
  • Biochemistry
  • Lou Gehrig's Disease
  • Neurology
  • Nutrition

Education

Degree

University of Wisconsin, School of Medicine and Public Health, Madison

Residency

University of Wisconsin, Madison
University of Virginia Hospital, Charlottesville

Certifications or Special training

American Board of Psychiatry and Neurology, Neurology

Additional information

Profile
My name is Edward J. Kasarskis; I received my medical degree from the University of Wisconsin, School of Medicine and Public Health, Madison. I am board certified by the American Board of Psychiatry and Neurology in Neurology.

Research/Publications

  1. Gal J, Kuang L, Barnett KR, Zhu BZ, Shissler SC, Korotkov KV, Hayward LJ, Kasarskis EJ, Zhu H. ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics. Acta Neuropathol. 2016 Aug 1.
    View in: PubMed
  2. Murphy J, Factor-Litvak P, Goetz R, Lomen-Hoerth C, Nagy PL, Hupf J, Singleton J, Woolley S, Andrews H, Heitzman D, Bedlack RS, Katz JS, Barohn RJ, Sorenson EJ, Oskarsson B, Fernandes Filho JA, Kasarskis EJ, Mozaffar T, Rollins YD, Nations SP, Swenson AJ, Koczon-Jaremko BA, Mitsumoto H. Cognitive-behavioral screening reveals prevalent impairment in a large multicenter ALS cohort. Neurology. 2016 Mar 1;86(9):813-20.
    View in: PubMed
  3. Gibson SB, Kasarskis EJ, Hu N, Pulst SM, Mendiondo MS, Matthews DE, Mitsumoto H, Tandan R, Simmons Z, Kryscio RJ, Bromberg MB. Relationship of creatine kinase to body composition, disease state, and longevity in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(7-8):473-7.
    View in: PubMed
  4. Kasarskis EJ, Mendiondo MS, Matthews DE, Mitsumoto H, Tandan R, Simmons Z, Bromberg MB, Kryscio RJ. Estimating daily energy expenditure in individuals with amyotrophic lateral sclerosis. Am J Clin Nutr. 2014 Apr;99(4):792-803.
    View in: PubMed
  5. Dhar SK, Zhang J, Gal J, Xu Y, Miao L, Lynn BC, Zhu H, Kasarskis EJ, St Clair DK. FUsed in sarcoma is a novel regulator of manganese superoxide dismutase gene transcription. Antioxid Redox Signal. 2014 Apr 1;20(10):1550-66.
    View in: PubMed
  6. Kasarskis EJ, Hodskins J, St Clair WH. Unilateral parotid electron beam radiotherapy as palliative treatment for sialorrhea in amyotrophic lateral sclerosis. J Neurol Sci. 2011 Sep 15; 308(1-2):155-7. PMID: 21726879.
    View in: PubMed
  7. Kasarskis EJ. What does body mass index measure in amyotrophic lateral sclerosis and why should we care? Muscle Nerve. 2011 Jul; 44(1):4-5. PMID: 21607986.
    View in: PubMed
  8. Kasarskis EJ, Mendiondo MS, Wells S, Malguizo MS, Thompson M, Healey M, Kryscio RJ. The ALS Nutrition/NIPPV Study: design, feasibility, and initial results. Amyotroph Lateral Scler. 2011 Jan; 12(1):17-25. PMID: 21271789.
    View in: PubMed
  9. Bedlack RS, Wicks P, Heywood J, Kasarskis E. Modifiable barriers to enrollment in American ALS research studies. Amyotroph Lateral Scler. 2010 Dec; 11(6):502-7. PMID: 20446890.
    View in: PubMed
  10. Horner RD, Feussner JR, Kasarskis EJ. Neurological mortality among Gulf War veterans. Am J Ind Med. 2010 May; 53(5):548-9. PMID: 20191602.
    View in: PubMed
  11. Khishchenko N, Allen KD, Coffman CJ, Kasarskis EJ, Lindquist JH, Morgenlander JC, Norman BB, Oddone EZ, Rozear MP, Sabet A, Sams L, Bedlack RS. Time to diagnosis in the National Registry of Veterans with Amyotrophic Lateral Sclerosis. Amyotroph Lateral Scler. 2010; 11(1-2):125-32. PMID: 19153849.
    View in: PubMed
  12. Pastula DM, Coffman CJ, Allen KD, Oddone EZ, Kasarskis EJ, Lindquist JH, Morgenlander JC, Norman BB, Rozear MP, Sams LA, Sabet A, Bedlack RS. Factors associated with survival in the National Registry of Veterans with ALS. Amyotroph Lateral Scler. 2009 Oct-Dec; 10(5-6):332-8. PMID: 19922120.
    View in: PubMed
  13. Kaufmann P, Thompson JL, Levy G, Buchsbaum R, Shefner J, Krivickas LS, Katz J, Rollins Y, Barohn RJ, Jackson CE, Tiryaki E, Lomen-Hoerth C, Armon C, Tandan R, Rudnicki SA, Rezania K, Sufit R, Pestronk A, Novella SP, Heiman-Patterson T, Kasarskis EJ, Pioro EP, Montes J, Arbing R, Vecchio D, Barsdorf A, Mitsumoto H, Levin B. Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III. Ann Neurol. 2009 Aug; 66(2):235-44. PMID: 19743457.
    View in: PubMed
  14. Fee DB, Kasarskis EJ. Myasthenia gravis associated with etanercept therapy. Muscle Nerve. 2009 Jun; 39(6):866-70. PMID: 19373885.
    View in: PubMed
  15. Roach AR, Averill AJ, Segerstrom SC, Kasarskis EJ. The dynamics of quality of life in ALS patients and caregivers. Ann Behav Med. 2009 Apr; 37(2):197-206. PMID: 19350337.
    View in: PubMed
  16. Kasarskis EJ, Lindquist JH, Coffman CJ, Grambow SC, Feussner JR, Allen KD, Oddone EZ, Kamins KA, Horner RD. Clinical aspects of ALS in Gulf War veterans. Amyotroph Lateral Scler. 2009 Feb; 10(1):35-41. PMID: 18792848.
    View in: PubMed
  17. Xu Y, Fang F, Dhar SK, Bosch A, St Clair WH, Kasarskis EJ, St Clair DK. Mutations in the SOD2 promoter reveal a molecular basis for an activating protein 2-dependent dysregulation of manganese superoxide dismutase expression in cancer cells. Mol Cancer Res. 2008 Dec; 6(12):1881-93. PMID: 19074833.
    View in: PubMed
  18. Horner RD, Grambow SC, Coffman CJ, Lindquist JH, Oddone EZ, Allen KD, Kasarskis EJ. Amyotrophic lateral sclerosis among 1991 Gulf War veterans: evidence for a time-limited outbreak. Neuroepidemiology. 2008; 31(1):28-32. PMID: 18535397.
    View in: PubMed
  19. Schmidt S, Allen KD, Loiacono VT, Norman B, Stanwyck CL, Nord KM, Williams CD, Kasarskis EJ, Kamel F, McGuire V, Nelson LM, Oddone EZ. Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis: the GENEVA study. Rationale, study design and demographic characteristics. Neuroepidemiology. 2008; 30(3):191-204. PMID: 18421219.
    View in: PubMed
  20. Ström AL, Gal J, Shi P, Kasarskis EJ, Hayward LJ, Zhu H. Retrograde axonal transport and motor neuron disease. J Neurochem. 2008 Jul; 106(2):495-505. PMID: 18384644.
    View in: PubMed
  21. Gwinn K, Corriveau RA, Mitsumoto H, Bednarz K, Brown RH, Cudkowicz M, Gordon PH, Hardy J, Kasarskis EJ, Kaufmann P, Miller R, Sorenson E, Tandan R, Traynor BJ, Nash J, Sherman A, Mailman MD, Ostell J, Bruijn L, Cwik V, Rich SS, Singleton A, Refolo L, Andrews J, Zhang R, Conwit R, Keller MA. Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery. PLoS One. 2007; 2(12):e1254. PMID: 18060051.
    View in: PubMed
  22. Averill AJ, Kasarskis EJ, Segerstrom SC. Psychological health in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2007 Aug; 8(4):243-54. PMID: 17653923.
    View in: PubMed
  23. Xu Y, Fang F, Dhar SK, St Clair WH, Kasarskis EJ, St Clair DK. The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene. J Biol Chem. 2007 Jun 1; 282(22):15981-94. PMID: 17426024.
    View in: PubMed
  24. DiMartino L, Allen KD, Kasarskis E, Lindquist JH, Coffman CJ, Oddone EZ. Characteristics associated with participation in DNA banking: The National Registry of Veterans with ALS. Contemp Clin Trials. 2007 Sep; 28(5):572-82. PMID: 17321220.
    View in: PubMed
  25. Mitsumoto H, Bromberg M, Johnston W, Tandan R, Byock I, Lyon M, Miller RG, Appel SH, Benditt J, Bernat JL, Borasio GD, Carver AC, Clawson L, Del Bene ML, Kasarskis EJ, LeGrand SB, Mandler R, McCarthy J, Munsat T, Newman D, Sufit RL, Versenyi A. Promoting excellence in end-of-life care in ALS. Amyotroph Lateral Scler Other Motor Neuron Disord. 2005 Sep; 6(3):145-54. PMID: 16183556.
    View in: PubMed
  26. Horner RD, Feussner JR, Kasarskis EJ. Prospective study of military service and mortality from ALS. Neurology. 2005 Jul 12; 65(1):180-1; author reply 180-1. PMID: 16009927.
    View in: PubMed
  27. Kasarskis EJ, Dempsey-Hall L, Thompson MM, Luu LC, Mendiondo M, Kryscio R. Rating the severity of ALS by caregivers over the telephone using the ALSFRS-R. Amyotroph Lateral Scler Other Motor Neuron Disord. 2005 Mar; 6(1):50-4. PMID: 16036426.
    View in: PubMed
  28. Kasarskis E. Disease-modifying interventions. Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Sep; 5 Suppl 1:76-8. PMID: 15512879.
    View in: PubMed
  29. St Clair D, Kasarskis E. Genetic polymorphism of the human manganese superoxide dismutase: what difference does it make? Pharmacogenetics. 2003 Mar; 13(3):129-30. PMID: 12618590.
    View in: PubMed
  30. Plahuta JM, McCulloch BJ, Kasarskis EJ, Ross MA, Walter RA, McDonald ER. Amyotrophic lateral sclerosis and hopelessness: psychosocial factors. Soc Sci Med. 2002 Dec; 55(12):2131-40. PMID: 12409126.
    View in: PubMed
  31. Daosukho C, Kiningham K, Kasarskis EJ, Ittarat W, St Clair DK. Tamoxifen enhancement of TNF-alpha induced MnSOD expression: modulation of NF-kappaB dimerization. Oncogene. 2002 May 16; 21(22):3603-10. PMID: 12032862.
    View in: PubMed
  32. Pedersen WA, Luo H, Kruman I, Kasarskis E, Mattson MP. The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis. FASEB J. 2000 May; 14(7):913-24. PMID: 10783145.
    View in: PubMed
  33. Kasarskis EJ, Scarlata D, Hill R, Fuller C, Stambler N, Cedarbaum JM. A retrospective study of percutaneous endoscopic gastrostomy in ALS patients during the BDNF and CNTF trials. J Neurol Sci. 1999 Oct 31; 169(1-2):118-25. PMID: 10540019.
    View in: PubMed
  34. Xu Y, Kiningham KK, Devalaraja MN, Yeh CC, Majima H, Kasarskis EJ, St Clair DK. An intronic NF-kappaB element is essential for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-alpha and interleukin-1beta. DNA Cell Biol. 1999 Sep; 18(9):709-22. PMID: 10492402.
    View in: PubMed
  35. Xu Y, Krishnan A, Wan XS, Majima H, Yeh CC, Ludewig G, Kasarskis EJ, St Clair DK. Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells. Oncogene. 1999 Jan 7; 18(1):93-102. PMID: 9926924.
    View in: PubMed
  36. Pedersen WA, Fu W, Keller JN, Markesbery WR, Appel S, Smith RG, Kasarskis E, Mattson MP. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Ann Neurol. 1998 Nov; 44(5):819-24. PMID: 9818940.
    View in: PubMed
  37. Tomblyn M, Kasarskis EJ, Xu Y, St Clair DK. Distribution of MnSOD polymorphisms in sporadic ALS patients. J Mol Neurosci. 1998 Feb; 10(1):65-6. PMID: 9589371.
    View in: PubMed
  38. Kasarskis EJ, Berryman S, English T, Nyland J, Vanderleest JG, Schneider A, Berger R, McClain C. The use of upper extremity anthropometrics in the clinical assessment of patients with amyotrophic lateral sclerosis. Muscle Nerve. 1997 Mar; 20(3):330-5. PMID: 9052812.
    View in: PubMed
  39. Kasarskis EJ, Neville HE. Management of ALS: nutritional care. Neurology. 1996 Oct; 47(4 Suppl 2):S118-20. PMID: 8858066.
    View in: PubMed
  40. Porter JD, Goldstein LA, Kasarskis EJ, Brueckner JK, Spear BT. The neuronal voltage-gated sodium channel, Scn8a, is essential for postnatal maturation of spinal, but not oculomotor, motor units. Exp Neurol. 1996 Jun; 139(2):328-34. PMID: 8654536.
    View in: PubMed
  41. Young B, Ott L, Kasarskis E, Rapp R, Moles K, Dempsey RJ, Tibbs PA, Kryscio R, McClain C. Zinc supplementation is associated with improved neurologic recovery rate and visceral protein levels of patients with severe closed head injury. J Neurotrauma. 1996 Jan; 13(1):25-34. PMID: 8714860.
    View in: PubMed
  42. Kasarskis EJ, Berryman S, Vanderleest JG, Schneider AR, McClain CJ. Nutritional status of patients with amyotrophic lateral sclerosis: relation to the proximity of death. Am J Clin Nutr. 1996 Jan; 63(1):130-7. PMID: 8604660.
    View in: PubMed
  43. Kasarskis EJ, Tandon L, Lovell MA, Ehmann WD. Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study. J Neurol Sci. 1995 Jun; 130(2):203-8. PMID: 8586987.
    View in: PubMed
  44. Kelafant GA, Kasarskis EJ, Horstman SW, Cohen C, Frank AL. Arsenic poisoning in central Kentucky: a case report. Am J Ind Med. 1993 Dec; 24(6):723-6. PMID: 7508681.
    View in: PubMed
  45. McClain C, Stuart M, Kasarskis E, Humphries L. Zinc, appetite regulation and eating disorders. Prog Clin Biol Res. 1993; 380:47-64. PMID: 8456137.
    View in: PubMed
  46. Kasarskis EJ, Ehmann WD, Markesbery WR. Trace metals in human neurodegenerative diseases. Prog Clin Biol Res. 1993; 380:299-310. PMID: 8456132.
    View in: PubMed
  47. Kasarskis EJ, Kuo CS, Berger R, Nelson KR. Carbamazepine-induced cardiac dysfunction. Characterization of two distinct clinical syndromes. Arch Intern Med. 1992 Jan; 152(1):186-91. PMID: 1728915.
    View in: PubMed
  48. Khare SS, Ehmann WD, Kasarskis EJ, Markesbery WR. Trace element imbalances in amyotrophic lateral sclerosis. Neurotoxicology. 1990; 11(3):521-32. PMID: 2284056.
    View in: PubMed
  49. Gilmore RL, Kasarskis EJ, Carr WA, Norvell E. Comparative impact of paraclinical studies in establishing the diagnosis of multiple sclerosis. Electroencephalogr Clin Neurophysiol. 1989 Nov; 73(5):433-42. PMID: 2479522.
    View in: PubMed
  50. Kasarskis EJ, Winslow M. When did Lou Gehrig's personal illness begin? Neurology. 1989 Sep; 39(9):1243-5. PMID: 2671792.
    View in: PubMed
  51. Stallones L, Kasarskis EJ, Stipanowich C, Snider G. Secular trends in mortality rates from motor neuron disease in Kentucky 1964-1984. Neuroepidemiology. 1989; 8(2):68-78. PMID: 2922100.
    View in: PubMed
  52. Kasarskis EJ, O'Connor W, Earle G. Embolic stroke from cardiac papillary fibroelastomas. Stroke. 1988 Sep; 19(9):1171-3. PMID: 3413815.
    View in: PubMed
  53. Kasarskis EJ, Tibbs PA, Lee C. Cerebellar hemangioblastoma symptomatic during pregnancy. Neurosurgery. 1988 Apr; 22(4):770-2. PMID: 3287215.
    View in: PubMed
  54. McClain CJ, Kasarskis EJ, Allen JJ. Functional consequences of zinc deficiency. Prog Food Nutr Sci. 1985; 9(1-2):185-226. PMID: 3911268.
    View in: PubMed