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fleischman-roger

Roger A. Fleischman, MD, PhD

Section Chief, Hematology/Oncology, Lexington VA Hospital

Practice areas

  • Hematology and Blood & Marrow Transplantation

Faculty rank

Associate Professor of Medicine

Clinic information

Clinical interests

  • Hematology
  • Leukemia
  • Lymphoma
  • Myelodysplastic Disorders
  • Myeloproliferative Disorders

Education

Degree

Harvard Medical School, Cambridge, Mass.

Residency

Peter Bent Brigham Hospital, Boston

Fellowship

University of Pennsylvania, School of Medicine, Philadelphia

Certifications or Special training

American Board of Internal Medicine
American Board of Internal Medicine, Hematology

Additional information

Profile

My name is Roger A. Fleischman; I received my undergraduate and medical degrees from Harvard College and Harvard Medical School in Cambridge, Mass. After a medical residency at the Brigham and Women’s Hospital in Boston, I completed a fellowship in Hematology and Oncology at the University of Pennsylvania School of Medicine in Philadelphia. During the fellowship, I also engaged in basic research in the biology of blood and bone marrow stem cells at the Institute for Cancer Research at the Fox Chase Cancer Center in Philadelphia.

I accepted my first faculty position in Hematology/Oncology at the University of Texas Southwestern Medical School, Dallas in 1983 and served as a practicing clinician at Parkland Memorial Hospital in Dallas as well as a clinical and basic researcher into the molecular causes of bone marrow and stem cell disorders.

In 1993, I left Texas for the University of Kentucky and was appointed an Associate Professor of Internal Medicine in the Hematology/Oncology Division. As part of my duties at UK HealthCare, I also serve as Chief of the Hematology/Oncology Section at the Lexington VA Hospital. At UK HealthCare, I see patients primarily with lymphoma, leukemia, and other bone marrow disorders.

I have published many research papers and abstracts and my research has been presented at numerous meetings both national and international. I was also recently recognized by the Hematology/Oncology fellows for outstanding teaching. I received 2015 designation as a Distinguished Emeritus Member by the American Society of Hematology for “exemplary service and efforts in the advancement of the field of hematology”. I am married to Dr. Elizabeth Piercy, an Infectious Disease specialist in private practice in Lexington and we have two daughters.

Research/Publications

  1. Fleischman RA. Polycythemia vera and the Jak2(V617F) mutation in a case of hereditary spherocytosis. Am J Med Sci. 2013 Oct;346(4):328-30.
    View in: PubMed
  2. Geiger H, True JM, Grimes B, Carroll EJ, Fleischman RA, Van Zant G. Analysis of the hematopoietic potential of muscle-derived cells in mice. Blood. 2002 Jul 15; 100(2):721-3. PMID: 12091375.
    View in: PubMed
  3. Fleischman RA, Letestu R, Mi X, Stevens D, Winters J, Debili N, Vainchenker W. Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome. Br J Haematol. 2002 Feb; 116(2):367-75. PMID: 11841440.
    View in: PubMed
  4. Fleischman RA, Gallardo T, Mi X. Mutations in the ligand-binding domain of the kit receptor: an uncommon site in human piebaldism. J Invest Dermatol. 1996 Nov; 107(5):703-6. PMID: 8875953.
    View in: PubMed
  5. Fleischman RA, Simpson F, Gallardo T, Jin XL, Perkins S. Isolation of endothelial-like stromal cells that express Kit ligand and support in vitro hematopoiesis. Exp Hematol. 1995 Dec; 23(13):1407-16. PMID: 7498370.
    View in: PubMed
  6. Fleischman RA. From white spots to stem cells: the role of the Kit receptor in mammalian development. Trends Genet. 1993 Aug; 9(8):285-90. PMID: 7691001.
    View in: PubMed
  7. Fleischman RA. Southwestern Internal Medicine Conference: clinical use of hematopoietic growth factors. Am J Med Sci. 1993 Apr; 305(4):248-73. PMID: 7682752.
    View in: PubMed
  8. Fleischman RA. Effect of the c-kit codon 584 Phe----Leu substitution demonstrated in human piebaldism. Am J Hum Genet. 1992 Sep; 51(3):677-8. PMID: 1379775.
    View in: PubMed
  9. Fleischman RA. Human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene. J Clin Invest. 1992 Jun; 89(6):1713-7. PMID: 1376329.
    View in: PubMed
  10. Van Zant G, Scott-Micus K, Thompson BP, Fleischman RA, Perkins S. Stem cell quiescence/activation is reversible by serial transplantation and is independent of stromal cell genotype in mouse aggregation chimeras. Exp Hematol. 1992 May; 20(4):470-5. PMID: 1568464.
    View in: PubMed
  11. Fleischman RA, Saltman DL, Stastny V, Zneimer S. Deletion of the c-kit protooncogene in the human developmental defect piebald trait. Proc Natl Acad Sci U S A. 1991 Dec 1; 88(23):10885-9. PMID: 1720553.
    View in: PubMed
  12. Fleischman RA. Human gene therapy. Am J Med Sci. 1991 May; 301(5):353-63. PMID: 2021158.
    View in: PubMed
  13. Perkins S, Fleischman RA. Stromal cell progeny of murine bone marrow fibroblast colony-forming units are clonal endothelial-like cells that express collagen IV and laminin. Blood. 1990 Feb 1; 75(3):620-5. PMID: 2404524.
    View in: PubMed
  14. Perkins S, Fleischman RA. Hematopoietic microenvironment. Origin, lineage, and transplantability of the stromal cells in long-term bone marrow cultures from chimeric mice. J Clin Invest. 1988 Apr; 81(4):1072-80. PMID: 3350965.
    View in: PubMed
  15. Fleischman RA. Successful transplantation of Friend virus-induced preleukemia into stem cell-deficient fetal mice. Blood. 1988 Mar; 71(3):800-3. PMID: 3278757.
    View in: PubMed
  16. Witte PL, Robinson M, Henley A, Low MG, Stiers DL, Perkins S, Fleischman RA, Kincade PW. Relationships between B-lineage lymphocytes and stromal cells in long-term bone marrow cultures. Eur J Immunol. 1987 Oct; 17(10):1473-84. PMID: 2960538.
    View in: PubMed
  17. Fleischman RA, Mintz B. Development of adult bone marrow stem cells in H-2-compatible and -incompatible mouse fetuses. J Exp Med. 1984 Mar 1; 159(3):731-45. PMID: 6607968.
    View in: PubMed
  18. Fleischman RA, Custer RP, Mintz B. Totipotent hematopoietic stem cells: normal self-renewal and differentiation after transplantation between mouse fetuses. Cell. 1982 Sep; 30(2):351-9. PMID: 6128075.
    View in: PubMed
  19. Fleischman RA, Mintz B. Prevention of genetic anemias in mice by microinjection of normal hematopoietic stem cells into the fetal placenta. Proc Natl Acad Sci U S A. 1979 Nov; 76(11):5736-40. PMID: 42904.
    View in: PubMed