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Practice areas

  • Brain Cancer Team
  • Head and Neck Cancer Team
  • Lung and Thoracic Cancer Team
  • Medical Oncology

Faculty rank

Professor of Medicine
Buck-Kentucky Lung Cancer Research Chair

Clinic information

Clinical interests

  • Head and Neck Cancer
  • Lung Cancer
  • Medical Oncology

Education

Degree

University of Kentucky, College of Medicine, Lexington

Residency

Internal Medicine, University of Virginia Health System, Charlottesville

Fellowship

Medical Oncology and Hematology, University of Kentucky, Lexington

Certifications or Special training

American Board of Internal Medicine
American Board of Internal Medicine, Medical Oncology

Additional information

Profile

My name is Susanne M. Arnold; I received my medical degree from the University of Kentucky, College of Medicine, Lexington. I completed a residency in Internal Medicine at the University of Virginia and fellowship in Medical Oncology and Hematology at the University of Kentucky, Lexington.

I am board certified by the American Board of Internal Medicine in Medical Oncology. I am the Associate Director of Clinical Translation of the Markey Cancer Center with interests in lung cancer, head and neck cancer and early therapeutics.

Personal statement

Some of my first memories are going with my dad to the hospital because he was a doctor, and that's how I first became interested in medicine. He was the director of the Center on Aging here for over 25 years, so I have great pride in being a second-generation doctor here at the University of Kentucky. Even deeper than that is my love of Kentucky, because I'm an eighth-generation Kentuckian and my children are ninth-generation Kentuckians. So, serving Kentucky in the little area that I can make a difference which is in cancer care, where we have some of the biggest health disparities and highest mortality rates, is really a calling to me.

Research/Publications

  1. Stewart RL, Carpenter BL, West DS, Knifley T, Liu L, Wang C, Weiss HL, Gal TS, Durbin EB, Arnold SM, O'Connor KL, Chen M. S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamide. Oncotarget. 2016 Apr 25.
    View in: PubMed
  2. Stocke NA, Arnold SM, Hilt JZ. Responsive Hydrogel Nanoparticles for Pulmonary Delivery. J Drug Deliv Sci Technol. 2015 Oct 1;29:143-151.
    View in: PubMed
  3. Silver NL, Arnold SM, Gleason JF, Kudrimoti M, Brill Y, Dressler EV, Valentino J. p16INK4a Status and Response to Induction Low-Dose Fractionated Radiation in Advanced Head and Neck Cancer. Ann Otol Rhinol Laryngol. 2015 Sep;124(9):714-20.
    View in: PubMed
  4. Stocke NA, Meenach SA, Arnold SM, Mansour HM, Hilt JZ. Formulation and characterization of inhalable magnetic nanocomposite microparticles (MnMs) for targeted pulmonary delivery via spray drying. Int J Pharm. 2015 Feb 20;479(2):320-8.
    View in: PubMed
  5. Tsakalozou E, Adane ED, Liang Y, Arnold SM, Leggas M. Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans. Cancer Chemother Pharmacol. 2014 Jul;74(1):45-54.
    View in: PubMed
  6. Warren GW, Arnold SM, Valentino JP, Gal TJ, Hyland AJ, Singh AK, Rangnekar VM, Cummings KM, Marshall JR, Kudrimoti MR. Accuracy of self-reported tobacco assessments in a head and neck cancer treatment population. Radiother Oncol. 2012 Apr; 103(1):45-8. PMID: 22119370.
    View in: PubMed
  7. Davis BN, Karabakhtsian RG, Pettigrew AL, Arnold SM, French CA, Brill YM. Nuclear protein in testis midline carcinomas: a lethal and underrecognized entity. Arch Pathol Lab Med. 2011 Nov; 135(11):1494-8. PMID: 22032580.
    View in: PubMed
  8. Mir SU, Ahmed IS, Arnold S, Craven RJ. Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients. Int J Cancer. 2012 Jul 15; 131(2):E1-9. PMID: 21918976.
    View in: PubMed
  9. Zhang Z, Wang X, Cheng S, Sun L, Son YO, Yao H, Li W, Budhraja A, Li L, Shelton BJ, Tucker T, Arnold SM, Shi X. Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/ß-catenin pathway in human colorectal adenocarcinoma DLD1 cells. Toxicol Appl Pharmacol. 2011 Oct 15; 256(2):114-21. PMID: 21854796.
    View in: PubMed
  10. Gupta S, Koru-Sengul T, Arnold SM, Devi GR, Mohiuddin M, Ahmed MM. Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells. Mol Cancer Ther. 2011 Feb; 10(2):292-302. PMID: 21216938.
    View in: PubMed
  11. Luftman V, Martin CA, Guenthner G, Arnold SM, Mullett TW, Jhaveri M. The power of videotaped personal statements of patients with lung cancer: a recruitment strategy for smoking prevention and cessation programs. Oncol Nurs Forum. 2011 Jan; 38(1):11-4. PMID: 21186155.
    View in: PubMed
  12. Horn J, Milewska M, Arnold SM, Leggas M. Metabolic pathways of the camptothecin analog AR-67. Drug Metab Dispos. 2011 Apr; 39(4):683-92. PMID: 21189330.
    View in: PubMed
  13. Wang-Gillam A, Arnold SM, Bukowski RM, Rothenberg ML, Cooper W, Wang KK, Gauthier E, Lockhart AC. A phase I dose escalation study of TTI-237 in patients with advanced malignant solid tumors. Invest New Drugs. 2012 Feb; 30(1):266-72. PMID: 20697774.
    View in: PubMed
  14. Jacobs-Lawson JM, Schumacher MM, Hughes T, Arnold S. Gender differences in psychosocial responses to lung cancer. Gend Med. 2010 Apr; 7(2):137-48. PMID: 20435276.
    View in: PubMed
  15. Arnold SM, Rinehart JJ, Tsakalozou E, Eckardt JR, Fields SZ, Shelton BJ, DeSimone PA, Kee BK, Moscow JA, Leggas M. A phase I study of 7-t-butyldimethylsilyl-10-hydroxycamptothecin in adult patients with refractory or metastatic solid malignancies. Clin Cancer Res. 2010 Jan 15; 16(2):673-80. PMID: 20068096.
    View in: PubMed
  16. Arnold SM, Moon J, Williamson SK, Atkins JN, Ou SH, LeBlanc M, Urba SG. Phase II evaluation of eribulin mesylate (E7389, NSC 707389) in patients with metastatic or recurrent squamous cell carcinoma of the head and neck: Southwest Oncology Group trial S0618. Invest New Drugs. 2011 Apr; 29(2):352-9. PMID: 19937365.
    View in: PubMed
  17. Stults DM, Killen MW, Williamson EP, Hourigan JS, Vargas HD, Arnold SM, Moscow JA, Pierce AJ. Human rRNA gene clusters are recombinational hotspots in cancer. Cancer Res. 2009 Dec 1; 69(23):9096-104. PMID: 19920195.
    View in: PubMed
  18. Jacobs-Lawson JM, Schumacher MM, Hughes T, Arnold S. The relationship between lung cancer patients' educational level and evaluation of their treatment information needs. J Cancer Educ. 2009; 24(4):346-50. PMID: 19838897.
    View in: PubMed
  19. Shareef MM, Brown B, Shajahan S, Sathishkumar S, Arnold SM, Mohiuddin M, Ahmed MM, Spring PM. Lack of P-glycoprotein expression by low-dose fractionated radiation results from loss of nuclear factor-kappaB and NF-Y activation in oral carcinoma cells. Mol Cancer Res. 2008 Jan; 6(1):89-98. PMID: 18234965.
    View in: PubMed
  20. Hughes T, Schumacher M, Jacobs-Lawson JM, Arnold S. Confronting death: perceptions of a good death in adults with lung cancer. Am J Hosp Palliat Care. 2008 Feb-Mar; 25(1):39-44. PMID: 18160544.
    View in: PubMed
  21. Regine WF, Hanna N, Garofalo MC, Doyle A, Arnold S, Kataria R, Sims J, Tan M, Mohiuddin M. Low-dose radiotherapy as a chemopotentiator of gemcitabine in tumors of the pancreas or small bowel: a phase I study exploring a new treatment paradigm. Int J Radiat Oncol Biol Phys. 2007 May 1; 68(1):172-7. PMID: 17276612.
    View in: PubMed
  22. Graves KD, Arnold SM, Love CL, Kirsh KL, Moore PG, Passik SD. Distress screening in a multidisciplinary lung cancer clinic: prevalence and predictors of clinically significant distress. Lung Cancer. 2007 Feb; 55(2):215-24. PMID: 17084483.
    View in: PubMed
  23. Doty JM, Gossman D, Kudrimoti M, Valentino J, Arnold S, Spring PM. Analysis of unknown primary carcinomas metastatic to the neck: diagnosis, treatment, and outcomes. J Ky Med Assoc. 2006 Feb; 104(2):57-64. PMID: 16594571.
    View in: PubMed
  24. Spring PM, Valentino J, Arnold SM, Sloan D, Kenady D, Kudrimoti M, Haydon RC, Lee C, Given C, Mohiuddin M, Regine WF. Long-term results of hyperfractionated radiation and high-dose intraarterial cisplatin for unresectable oropharyngeal carcinoma. Cancer. 2005 Oct 15; 104(8):1765-71. PMID: 16149090.
    View in: PubMed
  25. Michel SJ, Fried AM, Sinha S, Sinha S, Willson J, Bensadoun E, Arnold S, Buck JL. Comparison of iodixanol with iohexol for delayed pelvic venous opacification: a preliminary study of potential use for CT venography. AJR Am J Roentgenol. 2004 Jul; 183(1):123-6. PMID: 15208125.
    View in: PubMed
  26. Spring PM, Arnold SM, Shajahan S, Brown B, Dey S, Lele SM, Valentino J, Jones R, Mohiuddin M, Ahmed MM. Low dose fractionated radiation potentiates the effects of taxotere in nude mice xenografts of squamous cell carcinoma of head and neck. Cell Cycle. 2004 Apr; 3(4):479-85. PMID: 14963406.
    View in: PubMed
  27. Arnold SM, Regine WF, Ahmed MM, Valentino J, Spring P, Kudrimoti M, Kenady D, Desimone P, Mohiuddin M. Low-dose fractionated radiation as a chemopotentiator of neoadjuvant paclitaxel and carboplatin for locally advanced squamous cell carcinoma of the head and neck: results of a new treatment paradigm. Int J Radiat Oncol Biol Phys. 2004 Apr 1; 58(5):1411-7. PMID: 15050317.
    View in: PubMed
  28. Sloan AE, Arnold SM, St Clair WH, Regine WF. Brain injury: current management and investigations. Semin Radiat Oncol. 2003 Jul; 13(3):309-21. PMID: 12903019.
    View in: PubMed
  29. St Clair WH, Arnold SM, Sloan AE, Regine WF. Spinal cord and peripheral nerve injury: current management and investigations. Semin Radiat Oncol. 2003 Jul; 13(3):322-32. PMID: 12903020.
    View in: PubMed
  30. Kenady DE, Arnold SM, Regine WF, Mentzer RM. Oral/pharyngeal squamous carcinoma: treatment strategies. J Ky Med Assoc. 2002 Nov; 100(11):488-94. PMID: 12455455.
    View in: PubMed
  31. Valentino J, Spring PM, Shane M, Arnold SM, Regine WF. Interval pathologic assessments in patients treated with concurrent hyperfractionated radiation and intraarterial cisplatin (HYPERRADPLAT). Head Neck. 2002 Jun; 24(6):539-44. PMID: 12112550.
    View in: PubMed
  32. Regine WF, Valentino J, Arnold SM, Sloan D, Kenady D, Strottmann J, Mohiuddin M. A phase II study of concomitant hyperfractionated radiation therapy and double dose intra-arterial cisplatin for squamous cell carcinoma of the head and neck. Technol Cancer Res Treat. 2002 Apr; 1(2):133-40. PMID: 12622520.
    View in: PubMed
  33. Arnold SM, Patchell RA. Diagnosis and management of brain metastases. Hematol Oncol Clin North Am. 2001 Dec; 15(6):1085-107, vii. PMID: 11770300.
    View in: PubMed
  34. Spreer J, Martin P, Greenlee MW, Wohlfarth R, Hammen A, Arnold SM, Schumacher M. Functional MRI in patients with band heterotopia. Neuroimage. 2001 Aug; 14(2):357-65. PMID: 11467909.
    View in: PubMed
  35. Regine WF, Valentino J, Arnold SM, Haydon RC, Sloan D, Kenady D, Strottmann J, Pulmano C, Mohiuddin M. High-dose intra-arterial cisplatin boost with hyperfractionated radiation therapy for advanced squamous cell carcinoma of the head and neck. J Clin Oncol. 2001 Jul 15; 19(14):3333-9. PMID: 11454880.
    View in: PubMed
  36. Arnold SM, Els T, Spreer J, Schumacher M. Acute hepatic encephalopathy with diffuse cortical lesions. Neuroradiology. 2001 Jul; 43(7):551-4. PMID: 11512584.
    View in: PubMed
  37. Regine WF, Valentino J, John W, Storey G, Sloan D, Kenady D, Patel P, Pulmano C, Arnold SM, Mohiuddin M. High-dose intra-arterial cisplatin and concurrent hyperfractionated radiation therapy in patients with locally advanced primary squamous cell carcinoma of the head and neck: report of a phase II study. Head Neck. 2000 Sep; 22(6):543-9. PMID: 10941154.
    View in: PubMed
  38. Arnold SM, Young AB, Munn RK, Patchell RA, Nanayakkara N, Markesbery WR. Expression of p53, bcl-2, E-cadherin, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinases-1 in paired primary tumors and brain metastasis. Clin Cancer Res. 1999 Dec; 5(12):4028-33. PMID: 10632335.
    View in: PubMed
  39. Arnold SM, Van Zant G, Phillips G. Bi-phasic CD34+ cell mobilization of a syngeneic donor during prolonged G-CSF delivery. Cytotherapy. 1999; 1(2):119-22. PMID: 19746588.
    View in: PubMed
  40. Munn RK, Kramer CA, Arnold SM. Spinal cord compression due to extramedullary hematopoiesis in beta-thalassemia intermedia. Int J Radiat Oncol Biol Phys. 1998 Oct 1; 42(3):607-9. PMID: 9806521.
    View in: PubMed