Peter T. Nelson, MD, PhD

Practice areas

Practice areas

Clinical interests

  • Alzheimer's Disease
  • Dementia with Lewy Bodies
  • Hippocampal Sclerosis of Aging
  • MicroRNAs (MiRNAs)
  • Neuropathology

Peter T. Nelson, MD, PhD

Biography

My name is Peter Nelson; I received my medical degree, and a doctorate in philosophy in Neurobiology, from the University of Chicago Pritzker School of Medicine. I then completed anatomic pathology residency, neuropathology clinical fellowship, and post-doctoral fellowship at the University of Pennsylvania Medical Center, Philadelphia. I am board certified by the American Board of Pathology in Anatomic Pathology and Neuropathology. I am leader of the Neuropathology Core of the University of Kentucky Alzheimer's Disease Center.

My areas of interest include neuropathology, microRNAs (miRNAs), Alzheimer's disease, hippocampal sclerosis of aging (HS-Aging), dementia with Lewy bodies, and other neurodegenerative diseases.

Faculty rank

Professor of Pathology and Laboratory Medicine

Education

Degree
University of Chicago

Residency
University of Pennsylvania Hospital, Philadelphia

Fellowship
University of Pennsylvania Medical Center, Philadelphia

Certifications or Special training
American Board of Pathology
American Board of Pathology, Neuropathology

Pathology and Laboratory Medicine

UK Albert B. Chandler Hospital - Pavilion H
Room MS-117
800 Rose St.
Lexington KY 40536-0293

Call 859-323-5425
Fax 859-323-2094

Amenities
ATM, Dining, Gift shop, Information desk, Post office

Directions to UK Albert B. Chandler Hospital - Pavilion H Parking »


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  1. Pleiss MM, Sompol P, Kraner SD, Abdul HM, Furman JL, Guttmann RP, Wilcock DM, Nelson PT, Norris CM. Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function. Biochim Biophys Acta. 2016 Sep;1862(9):1521-32.
    View in: PubMed
  2. Abner EL, Nelson PT, Kryscio RJ, Schmitt FA, Fardo DW, Woltjer RL, Cairns NJ, Yu L, Dodge HH, Xiong C, Masaki K, Tyas SL, Bennett DA, Schneider JA, Arvanitakis Z. Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology. Alzheimers Dement. 2016 Aug;12(8):882-9.
    View in: PubMed
  3. Nelson PT. Cerebrovascular pathology and Alzheimer's disease. Lancet Neurol. 2016 Aug;15(9):895-6.
    View in: PubMed
  4. Kim J, Fiesel FC, Belmonte KC, Hudec R, Wang WX, Kim C, Nelson PT, Springer W, Kim J. miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1). Mol Neurodegener. 2016;11(1):55.
    PubMed
  5. Pietrzak M, Rempala GA, Nelson PT, Hetman M. Non-random distribution of methyl-CpG sites and non-CpG methylation in the human rDNA promoter identified by next generation bisulfite sequencing. Gene. 2016 Jul 1;585(1):35-43.
    PubMed
  6. Kryscio RJ, Abner EL, Lin Y, Cooper GE, Fardo DW, Jicha GA, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA. Adjusting for Mortality when Identifying Risk Factors for Transitions to Mild Cognitive Impairment and Dementia. J Alzheimers Dis. 2013 Mar 18. PMID: 23507772.
    View in: PubMed
  7. Nicholson AM, Baker MC, Finch NA, Rutherford NJ, Wider C, Graff-Radford NR, Nelson PT, Clark HB, Wszolek ZK, Dickson DW, Knopman DS, Rademakers R. CSF1R mutations link POLD and HDLS as a single disease entity. Neurology. 2013 Mar 12; 80(11):1033-1040. PMID: 23408870.
    View in: PubMed
  8. Rinker B, Fink BF, Stoker AR, Milan ME, Nelson PT. Calcium channel blockers reduce the effects of cigarette smoking on peripheral nerve ischemia/reperfusion injury. Ann Plast Surg. 2013 Feb; 70(2):222-6. PMID: 22395053.
    View in: PubMed
  9. Neltner JH, Abner EL, Schmitt FA, Denison SK, Anderson S, Patel E, Nelson PT. Digital pathology and image analysis for robust high-throughput quantitative assessment of Alzheimer disease neuropathologic changes. J Neuropathol Exp Neurol. 2012 Dec; 71(12):1075-85. PMID: 23147505.
    View in: PubMed
  10. Sudduth TL, Schmitt FA, Nelson PT, Wilcock DM. Neuroinflammatory phenotype in early Alzheimer's disease. Neurobiol Aging. 2013 Apr; 34(4):1051-9. PMID: 23062700.
    View in: PubMed
  11. Schmitt FA, Nelson PT, Abner E, Scheff S, Jicha GA, Smith C, Cooper G, Mendiondo M, Danner DD, Van Eldik LJ, Caban-Holt A, Lovell MA, Kryscio RJ. University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology. Curr Alzheimer Res. 2012 Jul; 9(6):724-33. PMID: 22471862.
    View in: PubMed
  12. Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. 2012 May; 71(5):362-81. PMID: 22487856.
    View in: PubMed
  13. Abner EL, Kryscio RJ, Cooper GE, Fardo DW, Jicha GA, Mendiondo MS, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA. Mild cognitive impairment: statistical models of transition using longitudinal clinical data. Int J Alzheimers Dis. 2012; 2012:291920. PMID: 22536535.
    View in: PubMed
  14. Grondin R, Kaytor MD, Ai Y, Nelson PT, Thakker DR, Heisel J, Weatherspoon MR, Blum JL, Burright EN, Zhang Z, Kaemmerer WF. Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum. Brain. 2012 Apr; 135(Pt 4):1197-209. PMID: 22252996.
    View in: PubMed
  15. Niedowicz DM, Nelson PT, Murphy MP. Alzheimer's disease: pathological mechanisms and recent insights. Curr Neuropharmacol. 2011 Dec; 9(4):674-84. PMID: 22654725.
    View in: PubMed
  16. Nelson PT, Wang WX, Mao G, Wilfred BR, Xie K, Jennings MH, Gao Z, Wang X. Specific sequence determinants of miR-15/107 microRNA gene group targets. Nucleic Acids Res. 2011 Oct; 39(18):8163-72. PMID: 21724616.
    View in: PubMed
  17. Nelson PT, Schmitt FA, Lin Y, Abner EL, Jicha GA, Patel E, Thomason PC, Neltner JH, Smith CD, Santacruz KS, Sonnen JA, Poon LW, Gearing M, Green RC, Woodard JL, Van Eldik LJ, Kryscio RJ. Hippocampal sclerosis in advanced age: clinical and pathological features. Brain. 2011 May; 134(Pt 5):1506-18. PMID: 21596774.
    View in: PubMed
  18. Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol. 2011 May; 121(5):571-87. PMID: 21516511.
    View in: PubMed
  19. Jicha GA, Abner EL, Schmitt FA, Kryscio RJ, Riley KP, Cooper GE, Stiles N, Mendiondo MS, Smith CD, Van Eldik LJ, Nelson PT. Preclinical AD Workgroup staging: pathological correlates and potential challenges. Neurobiol Aging. 2012 Mar; 33(3):622.e1-622.e16. PMID: 21507528.
    View in: PubMed
  20. Jicha GA, Nelson PT. Management of frontotemporal dementia: targeting symptom management in such a heterogeneous disease requires a wide range of therapeutic options. Neurodegener Dis Manag. 2011 Apr; 1(2):141-156. PMID: 21927623.
    View in: PubMed
  21. Madathil SK, Nelson PT, Saatman KE, Wilfred BR. MicroRNAs in CNS injury: potential roles and therapeutic implications. Bioessays. 2011 Jan; 33(1):21-6. PMID: 21053309.
    View in: PubMed
  22. Riley KP, Jicha GA, Davis D, Abner EL, Cooper GE, Stiles N, Smith CD, Kryscio RJ, Nelson PT, Van Eldik LJ, Schmitt FA. Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition. J Alzheimers Dis. 2011; 25(4):707-17. PMID: 21498903.
    View in: PubMed
  23. Abner EL, Kryscio RJ, Schmitt FA, Santacruz KS, Jicha GA, Lin Y, Neltner JM, Smith CD, Van Eldik LJ, Nelson PT. "End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction? J Alzheimers Dis. 2011; 25(3):445-53. PMID: 21471646.
    View in: PubMed
  24. Rinker B, Fink BF, Barry NG, Fife JA, Milan ME, Stoker AR, Nelson PT. The effect of cigarette smoking on functional recovery following peripheral nerve ischemia/reperfusion injury. Microsurgery. 2011 Jan; 31(1):59-65. PMID: 21207501.
    View in: PubMed
  25. Wang WX, Huang Q, Hu Y, Stromberg AJ, Nelson PT. Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter. Acta Neuropathol. 2011 Feb; 121(2):193-205. PMID: 20936480.
    View in: PubMed
  26. Wang WX, Kyprianou N, Wang X, Nelson PT. Dysregulation of the mitogen granulin in human cancer through the miR-15/107 microRNA gene group. Cancer Res. 2010 Nov 15; 70(22):9137-42. PMID: 20884628.
    View in: PubMed
  27. Finnerty JR, Wang WX, Hébert SS, Wilfred BR, Mao G, Nelson PT. The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases. J Mol Biol. 2010 Sep 24; 402(3):491-509. PMID: 20678503.
    View in: PubMed
  28. Nelson PT, Schmitt FA, Jicha GA, Kryscio RJ, Abner EL, Smith CD, Van Eldik LJ, Markesbery WR. Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol. 2010 Nov; 257(11):1875-81. PMID: 20563821.
    View in: PubMed
  29. Wang WX, Wilfred BR, Madathil SK, Tang G, Hu Y, Dimayuga J, Stromberg AJ, Huang Q, Saatman KE, Nelson PT. miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease. Am J Pathol. 2010 Jul; 177(1):334-45. PMID: 20489155.
    View in: PubMed
  30. Wang WX, Wilfred BR, Xie K, Jennings MH, Hu YH, Stromberg AJ, Nelson PT. Individual microRNAs (miRNAs) display distinct mRNA targeting "rules". RNA Biol. 2010 May-Jun; 7(3):373-80. PMID: 20421741.
    View in: PubMed
  31. Nelson PT, Kukull WA, Frosch MP. Thinking outside the box: Alzheimer-type neuropathology that does not map directly onto current consensus recommendations. J Neuropathol Exp Neurol. 2010 May; 69(5):449-54. PMID: 20418781.
    View in: PubMed
  32. Nelson PT, Kiriakidou M, Mourelatos Z, Tan GS, Jennings MH, Xie K, Wang WX. High-throughput experimental studies to identify miRNA targets directly, with special focus on the mammalian brain. Brain Res. 2010 Jun 18; 1338:122-30. PMID: 20380813.
    View in: PubMed
  33. Nelson PT, Dimayuga J, Wilfred BR. MicroRNA in Situ Hybridization in the Human Entorhinal and Transentorhinal Cortex. Front Hum Neurosci. 2010; 4:7. PMID: 20204141.
    View in: PubMed
  34. Cary LC, Maul E, Potter C, Wong P, Nelson PT, Given C, Robertson W. Balamuthia mandrillaris meningoencephalitis: survival of a pediatric patient. Pediatrics. 2010 Mar; 125(3):e699-703. PMID: 20123772.
    View in: PubMed
  35. Nelson PT, Wang WX. MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. J Alzheimers Dis. 2010; 21(1):75-9. PMID: 20413881.
    View in: PubMed
  36. Wang WX, Wilfred BR, Hu Y, Stromberg AJ, Nelson PT. Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes. RNA. 2010 Feb; 16(2):394-404. PMID: 20042474.
    View in: PubMed
  37. Nelson PT, Kryscio RJ, Jicha GA, Abner EL, Schmitt FA, Xu LO, Cooper G, Smith CD, Markesbery WR. Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies. Neurology. 2009 Oct 6; 73(14):1127-33. PMID: 19805729.
    View in: PubMed
  38. Nelson PT, Jicha GA, Kryscio RJ, Abner EL, Schmitt FA, Cooper G, Xu LO, Smith CD, Markesbery WR. Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol. 2010 Mar; 257(3):359-66. PMID: 19795154.
    View in: PubMed
  39. Nelson PT, Wilfred BR. In situ hybridization is a necessary experimental complement to microRNA (miRNA) expression profiling in the human brain. Neurosci Lett. 2009 Dec 4; 466(2):69-72. PMID: 19393719.
    View in: PubMed
  40. Nelson PT, Kryscio RJ, Abner EL, Schmitt FA, Jicha GA, Mendiondo MS, Cooper G, Smith CB, Markesbery WR. Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB. J Alzheimers Dis. 2009; 16(1):29-34. PMID: 19158418.
    View in: PubMed
  41. Nelson PT, Braak H, Markesbery WR. Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J Neuropathol Exp Neurol. 2009 Jan; 68(1):1-14. PMID: 19104448.
    View in: PubMed
  42. Jicha GA, Schmitt FA, Abner E, Nelson PT, Cooper GE, Smith CD, Markesbery WR. Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease. Neurobiol Aging. 2010 Oct; 31(10):1805-13. PMID: 19026468.
    View in: PubMed
  43. Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Davis DG, Poduska JW, Patel E, Mendiondo MS, Markesbery WR. Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol. 2010 Jan; 20(1):66-79. PMID: 19021630.
    View in: PubMed
  44. Nelson PT, Abner EL, Scheff SW, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Patel E, Markesbery WR. Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment. Neurosci Lett. 2009 Feb 6; 450(3):336-9. PMID: 19010392.
    View in: PubMed
  45. Nelson PT, Smith CD, Abner EA, Schmitt FA, Scheff SW, Davis GJ, Keller JN, Jicha GA, Davis D, Wang-Xia W, Hartman A, Katz DG, Markesbery WR. Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim Biophys Acta. 2009 May; 1792(5):454-69. PMID: 18789386.
    View in: PubMed
  46. Nelson PT, Wang WX, Wilfred BR, Tang G. Technical variables in high-throughput miRNA expression profiling: much work remains to be done. Biochim Biophys Acta. 2008 Nov; 1779(11):758-65. PMID: 18439437.
    View in: PubMed
  47. Wang WX, Wilfred BR, Baldwin DA, Isett RB, Ren N, Stromberg A, Nelson PT. Focus on RNA isolation: obtaining RNA for microRNA (miRNA) expression profiling analyses of neural tissue. Biochim Biophys Acta. 2008 Nov; 1779(11):749-57. PMID: 18316046.
    View in: PubMed
  48. Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, Rigoutsos I, Nelson PT. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci. 2008 Jan 30; 28(5):1213-23. PMID: 18234899.
    View in: PubMed
  49. Nelson PT, Wang WX, Rajeev BW. MicroRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol. 2008 Jan; 18(1):130-8. PMID: 18226108.
    View in: PubMed
  50. Nelson PT, Jicha GA, Schmitt FA, Liu H, Davis DG, Mendiondo MS, Abner EL, Markesbery WR. Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J Neuropathol Exp Neurol. 2007 Dec; 66(12):1136-46. PMID: 18090922.
    View in: PubMed
  51. Nelson PT, De Planell-Saguer M, Lamprinaki S, Kiriakidou M, Zhang P, O'Doherty U, Mourelatos Z. A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells. RNA. 2007 Oct; 13(10):1787-92. PMID: 17720879.
    View in: PubMed
  52. Nelson PT, Keller JN. RNA in brain disease: no longer just "the messenger in the middle". J Neuropathol Exp Neurol. 2007 Jun; 66(6):461-8. PMID: 17549006.
    View in: PubMed
  53. Wilfred BR, Wang WX, Nelson PT. Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol Genet Metab. 2007 Jul; 91(3):209-17. PMID: 17521938.
    View in: PubMed
  54. Nelson PT, Zhang PJ, Spagnoli GC, Tomaszewski JE, Pasha TL, Frosina D, Caballero OL, Simpson AJ, Old LJ, Jungbluth AA. Cancer/testis (CT) antigens are expressed in fetal ovary. Cancer Immun. 2007; 7:1. PMID: 17217256.
    View in: PubMed