Gerald (Gerry) S. Supinski, MD

Vice Chair Research

Clinical interests

  • Cardiopulmonary Interactions
  • Critical Care Medicine
  • Muscle Washing in Critical Illness
  • Myopathy
  • Pulmonary Medicine
  • Sepsis

Gerald (Gerry) S. Supinski, MD

Vice Chair Research

Biography

My name is Gerald Supinski; I received my medical degree from the University of Pittsburgh, School of Medicine. I then completed a fellowship at University Hospitals, Case Western Reserve University, Cleveland.

I am board certified by the American Board of Internal Medicine in Pulmonary Disease and Critical Care Medicine.

Faculty rank

Professor of Medicine

Education

Degree
University of Pittsburgh, School of Medicine

Residency
University Hospitals, Case Western Reserve University, Cleveland

Fellowship
University Hospitals, Case Western Reserve University, Cleveland

Certifications or Special training
American Board of Internal Medicine
American Board of Internal Medicine, Critical Care Medicine
American Board of Internal Medicine, Pulmonary Disease

Pulmonary Medicine and Critical Care

UK Good Samaritan Hospital
310 S. Limestone
Lexington KY 40508-3008

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  1. Callahan LA, Supinski GS. Early Mobilization in the ICU: Help or Hype? Crit Care Med. 2016 Jun;44(6):1239-40.
    View in: PubMed
  2. Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA. Calcium-dependent phospholipase A2 modulates infection-induced diaphragm dysfunction. Am J Physiol Lung Cell Mol Physiol. 2016 May 15;310(10):L975-84.
    View in: PubMed
  3. Supinski GS, Westgate P, Callahan LA. Correlation of maximal inspiratory pressure to transdiaphragmatic twitch pressure in intensive care unit patients. Crit Care. 2016;20:77.
    View in: PubMed
  4. Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA. Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 15;309(6):L614-24.
    View in: PubMed
  5. Supinski GS, Callahan LA. How Important is Diaphragm Function as a Determinant of Outcomes for MICU Patients in Respiratory Failure? Physiology (Bethesda). 2015 Sep;30(5):336-7.
    View in: PubMed
  6. Supinski GS, Callahan LA. Double-stranded RNA-dependent protein kinase activation modulates endotoxin-induced diaphragm weakness. J Appl Physiol. 2011 Jan; 110(1):199-205. PMID: 21071594.
    View in: PubMed
  7. Callahan LA, Supinski GS. Diaphragm weakness and mechanical ventilation--what's the critical issue? Crit Care. 2010; 14(4):187. PMID: 20701738.
    View in: PubMed
  8. Supinski GS, Vanags J, Callahan LA. Eicosapentaenoic acid preserves diaphragm force generation following endotoxin administration. Crit Care. 2010; 14(2):R35. PMID: 20233404.
    View in: PubMed
  9. Callahan LA, Supinski GS. Sepsis-induced myopathy. Crit Care Med. 2009 Oct; 37(10 Suppl):S354-67. PMID: 20046121.
    View in: PubMed
  10. Supinski GS, Wang W, Callahan LA. Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weakness. J Appl Physiol. 2009 Nov; 107(5):1389-96. PMID: 19661453.
    View in: PubMed
  11. Supinski GS, Murphy MP, Callahan LA. MitoQ administration prevents endotoxin-induced cardiac dysfunction. Am J Physiol Regul Integr Comp Physiol. 2009 Oct; 297(4):R1095-102. PMID: 19657095.
    View in: PubMed
  12. Supinski GS, Ji X, Callahan LA. The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation. Am J Physiol Regul Integr Comp Physiol. 2009 Sep; 297(3):R825-34. PMID: 19605759.
    View in: PubMed
  13. Supinski GS, Vanags J, Callahan LA. Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L994-L1001. PMID: 19376888.
    View in: PubMed
  14. Supinski GS, Callahan LA. Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction. Am J Respir Cell Mol Biol. 2010 Jan; 42(1):80-7. PMID: 19329553.
    View in: PubMed
  15. Callahan LA, Supinski GS. Hyperglycemia and acquired weakness in critically ill patients: potential mechanisms. Crit Care. 2009; 13(2):125. PMID: 19439021.
    View in: PubMed
  16. Supinski GS, Callahan LA. Free radical-mediated skeletal muscle dysfunction in inflammatory conditions. J Appl Physiol. 2007 May; 102(5):2056-63. PMID: 17218425.
    View in: PubMed
  17. Supinski GS, Ji X, Wang W, Callahan LA. The extrinsic caspase pathway modulates endotoxin-induced diaphragm contractile dysfunction. J Appl Physiol. 2007 Apr; 102(4):1649-57. PMID: 17218430.
    View in: PubMed
  18. Callahan LA, Supinski GS. Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis. J Appl Physiol. 2007 Jan; 102(1):44-53. PMID: 16916915.
    View in: PubMed
  19. Supinski GS, Callahan LA. Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction. Am J Respir Crit Care Med. 2006 Jun 1; 173(11):1240-7. PMID: 16514113.
    View in: PubMed
  20. Supinski GS, Callahan LA. Caspase activation contributes to endotoxin-induced diaphragm weakness. J Appl Physiol. 2006 Jun; 100(6):1770-7. PMID: 16484358.
    View in: PubMed
  21. Supinski GS, Callahan LA. Hemin prevents cardiac and diaphragm mitochondrial dysfunction in sepsis. Free Radic Biol Med. 2006 Jan 1; 40(1):127-37. PMID: 16337886.
    View in: PubMed
  22. Callahan LA, Supinski GS. Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis. J Appl Physiol. 2005 Sep; 99(3):1120-6. PMID: 16103521.
    View in: PubMed
  23. Supinski GS, Callahan LA. Diaphragmatic free radical generation increases in an animal model of heart failure. J Appl Physiol. 2005 Sep; 99(3):1078-84. PMID: 16103520.
    View in: PubMed
  24. Callahan LA, Supinski GS. Sepsis induces diaphragm electron transport chain dysfunction and protein depletion. Am J Respir Crit Care Med. 2005 Oct 1; 172(7):861-8. PMID: 15994462.
    View in: PubMed
  25. DiMarco AF, Kowalski KE, Supinski G, Romaniuk JR. Mechanism of expiratory muscle activation during lower thoracic spinal cord stimulation. J Appl Physiol. 2002 Jun; 92(6):2341-6. PMID: 12015345.
    View in: PubMed
  26. Ciufo R, Dimarco A, Stofan D, Nethery D, Supinski G. Dichloroacetate reduces diaphragmatic lactate formation but impairs respiratory performance. Am J Respir Crit Care Med. 2001 Nov 1; 164(9):1669-74. PMID: 11719308.
    View in: PubMed
  27. Callahan LA, Nethery D, Stofan D, DiMarco A, Supinski G. Free radical-induced contractile protein dysfunction in endotoxin-induced sepsis. Am J Respir Cell Mol Biol. 2001 Feb; 24(2):210-7. PMID: 11159056.
    View in: PubMed
  28. Callahan LA, Stofan DA, Szweda LI, Nethery DE, Supinski GS. Free radicals alter maximal diaphragmatic mitochondrial oxygen consumption in endotoxin-induced sepsis. Free Radic Biol Med. 2001 Jan 1; 30(1):129-38. PMID: 11134903.
    View in: PubMed
  29. Nethery D, Callahan LA, Stofan D, Mattera R, DiMarco A, Supinski G. PLA(2) dependence of diaphragm mitochondrial formation of reactive oxygen species. J Appl Physiol. 2000 Jul; 89(1):72-80. PMID: 10904037.
    View in: PubMed
  30. DiMarco AF, Romaniuk JR, Supinski G, Kowalski KE. Effects of lung volume on parasternal pressure-generating capacity in dogs. Exp Physiol. 2000 May; 85(3):331-7. PMID: 10825421.
    View in: PubMed
  31. Supinski G, Stofan D, Callahan LA, Nethery D, DiMarco A. Effects of protein kinase A inhibition on rat diaphragm force generation. Respir Physiol. 2000 Apr; 120(2):115-23. PMID: 10773242.
    View in: PubMed
  32. Supinski G, Nethery D, Nosek TM, Callahan LA, Stofan D, DiMarco A. Endotoxin administration alters the force vs. pCa relationship of skeletal muscle fibers. Am J Physiol Regul Integr Comp Physiol. 2000 Apr; 278(4):R891-6. PMID: 10749776.
    View in: PubMed
  33. Stofan DA, Callahan LA, DiMARCO AF, Nethery DE, Supinski GS. Modulation of release of reactive oxygen species by the contracting diaphragm. Am J Respir Crit Care Med. 2000 Mar; 161(3 Pt 1):891-8. PMID: 10712339.
    View in: PubMed
  34. Supinski G, Nethery D, Stofan D, DiMarco A. Extracellular calcium modulates generation of reactive oxygen species by the contracting diaphragm. J Appl Physiol. 1999 Dec; 87(6):2177-85. PMID: 10601165.
    View in: PubMed
  35. Nethery D, DiMarco A, Stofan D, Supinski G. Sepsis increases contraction-related generation of reactive oxygen species in the diaphragm. J Appl Physiol. 1999 Oct; 87(4):1279-86. PMID: 10517753.
    View in: PubMed
  36. DiMarco AF, Romaniuk JR, Kowalski KE, Supinski G. Mechanical contribution of expiratory muscles to pressure generation during spinal cord stimulation. J Appl Physiol. 1999 Oct; 87(4):1433-9. PMID: 10517775.
    View in: PubMed
  37. Supinski G, Nethery D, Stofan D, Szweda L, DiMarco A. Oxypurinol administration fails to prevent free radical-mediated lipid peroxidation during loaded breathing. J Appl Physiol. 1999 Sep; 87(3):1123-31. PMID: 10484586.
    View in: PubMed
  38. Nethery D, Stofan D, Callahan L, DiMarco A, Supinski G. Formation of reactive oxygen species by the contracting diaphragm is PLA(2) dependent. J Appl Physiol. 1999 Aug; 87(2):792-800. PMID: 10444641.
    View in: PubMed
  39. Supinski G, Stofan D, Callahan LA, Nethery D, Nosek TM, DiMarco A. Peroxynitrite induces contractile dysfunction and lipid peroxidation in the diaphragm. J Appl Physiol. 1999 Aug; 87(2):783-91. PMID: 10444640.
    View in: PubMed
  40. Supinski G, Stofan D, Nethery D, Szweda L, DiMarco A. Apocynin improves diaphragmatic function after endotoxin administration. J Appl Physiol. 1999 Aug; 87(2):776-82. PMID: 10444639.
    View in: PubMed
  41. DiMarco AF, Romaniuk JR, Kowalski KE, Supinski G. Pattern of expiratory muscle activation during lower thoracic spinal cord stimulation. J Appl Physiol. 1999 Jun; 86(6):1881-9. PMID: 10368352.
    View in: PubMed
  42. Supinski G, Nethery D, Stofan D, Hirschfield W, DiMarco A. Diaphragmatic lipid peroxidation in chronically loaded rats. J Appl Physiol. 1999 Feb; 86(2):651-8. PMID: 9931204.
    View in: PubMed
  43. Supinski G. Free radical induced respiratory muscle dysfunction. Mol Cell Biochem. 1998 Feb; 179(1-2):99-110. PMID: 9543353.
    View in: PubMed
  44. Poponick JM, Jacobs I, Supinski G, DiMarco AF. Effect of upper respiratory tract infection in patients with neuromuscular disease. Am J Respir Crit Care Med. 1997 Aug; 156(2 Pt 1):659-64. PMID: 9279255.
    View in: PubMed
  45. DiMarco AF, Romaniuk JR, Kowalski KE, Supinski GS. Efficacy of combined inspiratory intercostal and expiratory muscle pacing to maintain artificial ventilation. Am J Respir Crit Care Med. 1997 Jul; 156(1):122-6. PMID: 9230735.
    View in: PubMed
  46. Supinski GS, Stofan D, Ciufo R, DiMarco A. N-acetylcysteine administration alters the response to inspiratory loading in oxygen-supplemented rats. J Appl Physiol. 1997 Apr; 82(4):1119-25. PMID: 9104848.
    View in: PubMed
  47. Supinski G, Nethery D, Stofan D, DiMarco A. Effect of free radical scavengers on diaphragmatic fatigue. Am J Respir Crit Care Med. 1997 Feb; 155(2):622-9. PMID: 9032204.
    View in: PubMed
  48. Supinski G, Nethery D, Stofan D, DiMarco A. Comparison of the effects of endotoxin on limb, respiratory, and cardiac muscles. J Appl Physiol. 1996 Sep; 81(3):1370-8. PMID: 8889776.
    View in: PubMed
  49. Supinski G, Nethery D, Murhez N, Ciufo R, DiMarco A. Glutathione metabolic responses to loaded breathing: variation among respiratory muscles. J Appl Physiol. 1996 Sep; 81(3):1362-9. PMID: 8889775.
    View in: PubMed
  50. Ciufo R, Nethery D, DiMarco A, Supinski G. Effect of varying load magnitude on diaphragmatic glutathione metabolism during loaded breathing. Am J Respir Crit Care Med. 1995 Nov; 152(5 Pt 1):1641-7. PMID: 7582308.
    View in: PubMed
  51. Supinski GS, Nethery D, Ciufo R, Renston J, DiMarco A. Effect of varying inspired oxygen concentration on diaphragm glutathione metabolism during loaded breathing. Am J Respir Crit Care Med. 1995 Nov; 152(5 Pt 1):1633-40. PMID: 7582307.
    View in: PubMed
  52. Supinski GS, Stofan D, Ciufo R, DiMarco A. N-acetylcysteine administration and loaded breathing. J Appl Physiol. 1995 Jul; 79(1):340-7. PMID: 7559241.
    View in: PubMed
  53. DiMarco AF, Romaniuk JR, Supinski GS. Electrical activation of the expiratory muscles to restore cough. Am J Respir Crit Care Med. 1995 May; 151(5):1466-71. PMID: 7735601.
    View in: PubMed
  54. DiMarco AF, Supinski GS, Petro JA, Takaoka Y. Evaluation of intercostal pacing to provide artificial ventilation in quadriplegics. Am J Respir Crit Care Med. 1994 Oct; 150(4):934-40. PMID: 7921466.
    View in: PubMed
  55. DiMarco AF, Supinski GS, Kowalski KE, Romaniuk JR. Effects of pentobarbital anesthesia on intercostal muscle activation and shortening. J Appl Physiol. 1994 Aug; 77(2):925-32. PMID: 8002549.
    View in: PubMed
  56. Supinski G, DiMarco A, Dibner-Dunlap M. Alterations in diaphragm strength and fatiguability in congestive heart failure. J Appl Physiol. 1994 Jun; 76(6):2707-13. PMID: 7928904.
    View in: PubMed
  57. Anzueto A, Supinski GS, Levine SM, Jenkinson SG. Mechanisms of disease: are oxygen-derived free radicals involved in diaphragmatic dysfunction? Am J Respir Crit Care Med. 1994 Apr; 149(4 Pt 1):1048-52. PMID: 8143041.
    View in: PubMed
  58. DiMarco AF, Supinski GS, Simhai B, Romaniuk JR. Mechanical action of the internal intercostal muscles in dogs. J Appl Physiol. 1993 Dec; 75(6):2360-7. PMID: 8125851.
    View in: PubMed
  59. Supinski G, Stofan D, DiMarco A. Effect of ischemia-reperfusion on diaphragm strength and fatigability. J Appl Physiol. 1993 Nov; 75(5):2180-7. PMID: 8307877.
    View in: PubMed
  60. Supinski G, Nethery D, DiMarco A. Effect of free radical scavengers on endotoxin-induced respiratory muscle dysfunction. Am Rev Respir Dis. 1993 Nov; 148(5):1318-24. PMID: 8239170.
    View in: PubMed
  61. Romaniuk JR, Supinski GS, DiMarco AF. Reflex control of diaphragm activation by thoracic afferents. J Appl Physiol. 1993 Jul; 75(1):63-9. PMID: 8376303.
    View in: PubMed
  62. Supinski GS, Dick T, Stofan D, DiMarco AF. Effects of intraphrenic injection of potassium on diaphragm activation. J Appl Physiol. 1993 Mar; 74(3):1186-94. PMID: 8482657.
    View in: PubMed
  63. Supinski GS, Stofan D, Nashawati E, DiMarco AF. Failure of vasodilator administration to increase blood flow to the fatiguing diaphragm. J Appl Physiol. 1993 Mar; 74(3):1178-85. PMID: 8482656.
    View in: PubMed
  64. Nashawati E, Dimarco A, Supinski G. Effects produced by infusion of a free radical-generating solution into the diaphragm. Am Rev Respir Dis. 1993 Jan; 147(1):60-5. PMID: 8420433.
    View in: PubMed
  65. DiMarco AF, Romaniuk JR, Supinski GS. Parasternal and external intercostal responses to various respiratory maneuvers. J Appl Physiol. 1992 Sep; 73(3):979-86. PMID: 1400066.
    View in: PubMed
  66. Shindoh C, Dimarco A, Nethery D, Supinski G. Effect of PEG-superoxide dismutase on the diaphragmatic response to endotoxin. Am Rev Respir Dis. 1992 Jun; 145(6):1350-4. PMID: 1596002.
    View in: PubMed
  67. Supinski G, DiMarco AF, Hussein F, Bundy R, Altose M. Analysis of the contraction of series and parallel muscles working against elastic loads. Respir Physiol. 1992 Feb; 87(2):141-55. PMID: 1565888.
    View in: PubMed
  68. Shindoh C, Dimarco A, Lust W, Supinski G. Effect of acute fasting on diaphragm strength and endurance. Am Rev Respir Dis. 1991 Sep; 144(3 Pt 1):488-93. PMID: 1892284.
    View in: PubMed
  69. van Lunteren E, Salomone RJ, Manubay P, Supinski GS, Dick TE. Contractile and endurance properties of geniohyoid and diaphragm muscles. J Appl Physiol. 1990 Dec; 69(6):1992-7. PMID: 2076992.
    View in: PubMed
  70. Supinski GS, DiMarco AF, Gonzalez J, Altose MD. Effect of norepinephrine on diaphragm contractility and blood flow. J Appl Physiol. 1990 Dec; 69(6):2019-28. PMID: 2076996.
    View in: PubMed
  71. DiMarco AF, Romaniuk JR, Supinski GS. Parasternal and external intercostal muscle shortening during eupneic breathing. J Appl Physiol. 1990 Dec; 69(6):2222-6. PMID: 2077020.
    View in: PubMed
  72. Shindoh C, DiMarco A, Thomas A, Manubay P, Supinski G. Effect of N-acetylcysteine on diaphragm fatigue. J Appl Physiol. 1990 May; 68(5):2107-13. PMID: 2361912.
    View in: PubMed
  73. Supinski GS, DiMarco AF, Altose MD. Effect of diaphragmatic contraction on intramuscular pressure and vascular impedance. J Appl Physiol. 1990 Apr; 68(4):1486-93. PMID: 2347789.
    View in: PubMed
  74. Budzinska K, Supinski G, DiMarco AF. Inspiratory action of separate external and parasternal intercostal muscle contraction. J Appl Physiol. 1989 Oct; 67(4):1395-400. PMID: 2793741.
    View in: PubMed
  75. Supinski GS, DiMarco AF, Hussein F, Altose MD. Alterations in respiratory muscle activation in the ischemic fatigued canine diaphragm. J Appl Physiol. 1989 Aug; 67(2):720-9. PMID: 2793675.
    View in: PubMed
  76. Darian GB, DiMarco AF, Kelsen SG, Supinski GS, Gottfried SB. Effects of progressive hypoxia on parasternal, costal, and crural diaphragm activation. J Appl Physiol. 1989 Jun; 66(6):2579-84. PMID: 2745319.
    View in: PubMed
  77. DiMarco AF, Supinski GS, Budzinska K. Inspiratory muscle interaction in the generation of changes in airway pressure. J Appl Physiol. 1989 Jun; 66(6):2573-8. PMID: 2745318.
    View in: PubMed
  78. Bark H, Supinski G, Bundy R, Kelsen S. Effect of hypoxia on diaphragm blood flow, oxygen uptake, and contractility. Am Rev Respir Dis. 1988 Dec; 138(6):1535-41. PMID: 3202503.
    View in: PubMed
  79. Bundy RJ, Arnold JS, DiMarco AF, Hussein F, Supinski GS. Effect of amrinone on diaphragm blood flow. J Appl Physiol. 1988 Oct; 65(4):1506-13. PMID: 3182514.
    View in: PubMed
  80. Supinski GS, Arnold JS, Kelsen SG. Effect of theophylline on the velocity of diaphragmatic muscle shortening. J Appl Physiol. 1988 Sep; 65(3):1410-5. PMID: 3182507.
    View in: PubMed
  81. Supinski G, DiMarco A, Ketai L, Hussein F, Altose M. Reversibility of diaphragm fatigue by mechanical hyperperfusion. Am Rev Respir Dis. 1988 Sep; 138(3):604-9. PMID: 2974261.
    View in: PubMed
  82. Supinski GS, Clary SJ, Bark H, Kelsen SG. Effect of inspiratory muscle fatigue on perception of effort during loaded breathing. J Appl Physiol. 1987 Jan; 62(1):300-7. PMID: 3558189.
    View in: PubMed
  83. Bark H, Supinski GS, Lamanna JC, Kelsen SG. Relationship of changes in diaphragmatic muscle blood flow to muscle contractile activity. J Appl Physiol. 1987 Jan; 62(1):291-9. PMID: 3558188.
    View in: PubMed
  84. Thomas AJ, Supinski GS, Kelsen SG. Changes in chest wall structure and elasticity in elastase-induced emphysema. J Appl Physiol. 1986 Nov; 61(5):1821-9. PMID: 3640762.
    View in: PubMed
  85. Supinski GS, Levin S, Kelsen SG. Caffeine effect on respiratory muscle endurance and sense of effort during loaded breathing. J Appl Physiol. 1986 Jun; 60(6):2040-7. PMID: 3722070.
    View in: PubMed
  86. Supinski GS, Bark H, Guanciale A, Kelsen SG. Effect of alterations in muscle fiber length on diaphragm blood flow. J Appl Physiol. 1986 May; 60(5):1789-96. PMID: 3710994.
    View in: PubMed
  87. Oliven A, Supinski GS, Kelsen SG. Functional adaptation of diaphragm to chronic hyperinflation in emphysematous hamsters. J Appl Physiol. 1986 Jan; 60(1):225-31. PMID: 3632974.
    View in: PubMed
  88. Supinski GS, Kelsen SG. Effect of elastase-induced emphysema on the force-generating ability of the diaphragm. J Clin Invest. 1982 Nov; 70(5):978-88. PMID: 6922866.
    View in: PubMed