William H. St. Clair, MD, PhD

Co-Director, Gamma Knife® Radiosurgery Center

Clinical interests

  • General Radiation Medicine
  • Genitourinary and Central Nervous System (CNS) Neoplasms
  • Radiation Oncology

William H. St. Clair, MD, PhD

Co-Director, Gamma Knife® Radiosurgery Center

Biography

My name is William St. Clair; I received my medical degree from the University of Kentucky, College of Medicine, Lexington. I then completed a fellowship at Harvard University Medical Center, Boston.

I am board certified by the American Board of Radiology in Radiation Oncology.

Dr. William St. Clair discusses the role of multidisciplinary teams in Gamma Knife radiosurgery and what patients can expect during and after the procedure.

Faculty rank

Professor of Radiation Medicine

Education

Degree
MD, University of Kentucky, College of Medicine, Lexington
PhD, University of Iowa, College of Medicine, Iowa City

Residency
Massachusetts General Hospital, Boston

Fellowship
Harvard University Medical Center, Boston

Certifications or Special training
American Board of Radiology, Radiation Oncology 

Radiation Medicine

UK Albert B. Chandler Hospital - Pavilion H
Ground Floor
800 Rose St.
Lexington KY 40536-0293

Call 859-323-6486
Call 859-323-6487
Fax 859-257-4931

Amenities
ATM, Dining, Gift shop, Information desk, Post office

Directions to UK Albert B. Chandler Hospital - Pavilion H Parking »



Brain Cancer

Multidisciplinary Clinic

Markey Cancer Center
Whitney-Hendrickson Building
First Floor
800 Rose St.
Lexington KY 40536-0098

HBCicon120x123
This is a clinic of the University of Kentucky Hospital, also known as UK Albert B. Chandler Hospital. Read more »



Gastrointestinal Cancer

Multidisciplinary Clinic

Markey Cancer Center
Whitney-Hendrickson Building
First Floor
800 Rose St.
Lexington KY 40536-0098

HBCicon120x123
This is a clinic of the University of Kentucky Hospital, also known as UK Albert B. Chandler Hospital. Read more »

Call 859-257-4488
Call 866-340-4488

Directions to Markey Cancer Center »



Genitourinary Cancer

Multidisciplinary Clinic

Markey Cancer Center
Whitney-Hendrickson Building
First Floor
800 Rose St.
Lexington KY 40536-0098

HBCicon120x123
This is a clinic of the University of Kentucky Hospital, also known as UK Albert B. Chandler Hospital. Read more »

Call 859-257-4488
Call 866-340-4488

Directions to Markey Cancer Center »


UK HealthCare accepts many forms of insurance. See list of insurers »

 
  1. Xu Y, Fang F, St Clair DK, St Clair WH. Inverse relationship between PSA and IL-8 in prostate cancer: an insight into a NF-?B-mediated mechanism. PLoS One. 2012; 7(3):e32905. PMID: 22403723.
    View in: PubMed
  2. Kasarskis EJ, Hodskins J, St Clair WH. Unilateral parotid electron beam radiotherapy as palliative treatment for sialorrhea in amyotrophic lateral sclerosis. J Neurol Sci. 2011 Sep 15; 308(1-2):155-7. PMID: 21726879.
    View in: PubMed
  3. Xu Y, Fang F, Zhang J, Josson S, St Clair WH, St Clair DK. miR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes. PLoS One. 2010; 5(12):e14356. PMID: 21203553.
    View in: PubMed
  4. Sinthupibulyakit C, Ittarat W, St Clair WH, St Clair DK. p53 Protects lung cancer cells against metabolic stress. Int J Oncol. 2010 Dec; 37(6):1575-81. PMID: 21042727.
    View in: PubMed
  5. Holley AK, Xu Y, St Clair DK, St Clair WH. RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells. Ann N Y Acad Sci. 2010 Jul; 1201:129-36. PMID: 20649549.
    View in: PubMed
  6. Xu Y, Fang F, Sun Y, St Clair DK, St Clair WH. RelB-dependent differential radiosensitization effect of STI571 on prostate cancer cells. Mol Cancer Ther. 2010 Apr; 9(4):803-12. PMID: 20371728.
    View in: PubMed
  7. Sun Y, St Clair DK, Xu Y, Crooks PA, St Clair WH. A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res. 2010 Apr 1; 70(7):2880-90. PMID: 20233868.
    View in: PubMed
  8. Sinthupibulyakit C, Grimes KR, Domann FE, Xu Y, Fang F, Ittarat W, St Clair DK, St Clair W. p53 is an important factor for the radiosensitization effect of 2-deoxy-D-glucose. Int J Oncol. 2009 Sep; 35(3):609-15. PMID: 19639181.
    View in: PubMed
  9. Brelsfoard CL, St Clair W, Dobson SL. Integration of irradiation with cytoplasmic incompatibility to facilitate a lymphatic filariasis vector elimination approach. Parasit Vectors. 2009; 2(1):38. PMID: 19682363.
    View in: PubMed
  10. Xu Y, Josson S, Fang F, Oberley TD, St Clair DK, Wan XS, Sun Y, Bakthavatchalu V, Muthuswamy A, St Clair WH. RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity. Cancer Res. 2009 Apr 15; 69(8):3267-71. PMID: 19351823.
    View in: PubMed
  11. Xu Y, Fang F, Dhar SK, Bosch A, St Clair WH, Kasarskis EJ, St Clair DK. Mutations in the SOD2 promoter reveal a molecular basis for an activating protein 2-dependent dysregulation of manganese superoxide dismutase expression in cancer cells. Mol Cancer Res. 2008 Dec; 6(12):1881-93. PMID: 19074833.
    View in: PubMed
  12. Xu Y, Fang F, St Clair DK, Sompol P, Josson S, St Clair WH. SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation. Mol Cancer Ther. 2008 Aug; 7(8):2367-76. PMID: 18723484.
    View in: PubMed
  13. Sun Y, St Clair DK, Fang F, Warren GW, Rangnekar VM, Crooks PA, St Clair WH. The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN. Mol Cancer Ther. 2007 Sep; 6(9):2477-86. PMID: 17876045.
    View in: PubMed
  14. Xu Y, Fang F, St Clair DK, Josson S, Sompol P, Spasojevic I, St Clair WH. Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1alpha,25-dihydroxyvitamin D(3) in prostate cancer cells. Mol Cancer Ther. 2007 Jul; 6(7):2048-56. PMID: 17604335.
    View in: PubMed
  15. Xu Y, Fang F, Dhar SK, St Clair WH, Kasarskis EJ, St Clair DK. The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene. J Biol Chem. 2007 Jun 1; 282(22):15981-94. PMID: 17426024.
    View in: PubMed
  16. Huhn JL, Johnson EL, St Clair W. Adjuvant radiation of bilateral postauricular keloids: an illustration of technique. Med Dosim. 2007; 32(4):278-80. PMID: 17980828.
    View in: PubMed
  17. Tangpong J, Cole MP, Sultana R, Estus S, Vore M, St Clair W, Ratanachaiyavong S, St Clair DK, Butterfield DA. Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain. J Neurochem. 2007 Jan; 100(1):191-201. PMID: 17227439.
    View in: PubMed
  18. Grimes KR, Warren GW, Fang F, Xu Y, St Clair WH. Cyclooxygenase-2 inhibitor, nimesulide, improves radiation treatment against non-small cell lung cancer both in vitro and in vivo. Oncol Rep. 2006 Oct; 16(4):771-6. PMID: 16969492.
    View in: PubMed
  19. Tangpong J, Cole MP, Sultana R, Joshi G, Estus S, Vore M, St Clair W, Ratanachaiyavong S, St Clair DK, Butterfield DA. Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity. Neurobiol Dis. 2006 Jul; 23(1):127-39. PMID: 16697651.
    View in: PubMed
  20. Warren G, Grimes K, Xu Y, Kudrimoti M, St Clair W. Selectively enhanced radiation sensitivity in prostate cancer cells associated with proteasome inhibition. Oncol Rep. 2006 May; 15(5):1287-91. PMID: 16596199.
    View in: PubMed
  21. Josson S, Xu Y, Fang F, Dhar SK, St Clair DK, St Clair WH. RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells. Oncogene. 2006 Mar 9; 25(10):1554-9. PMID: 16261162.
    View in: PubMed
  22. Grimes KR, Daosukho C, Zhao Y, Meigooni A, St Clair W. Proteasome inhibition improves fractionated radiation treatment against non-small cell lung cancer: an antioxidant connection. Int J Oncol. 2005 Oct; 27(4):1047-52. PMID: 16142322.
    View in: PubMed
  23. Payne JT, St Clair WH, Given CA, Young B, Meigooni A. Double balloon GliaSite in the management of recurrent glioblastoma multiforme. South Med J. 2005 Sep; 98(9):957-8. PMID: 16220608.
    View in: PubMed
  24. Jahraus CD, Bettenhausen D, Malik U, Sellitti M, St Clair WH. Prevention of acute radiation-induced proctosigmoiditis by balsalazide: a randomized, double-blind, placebo controlled trial in prostate cancer patients. Int J Radiat Oncol Biol Phys. 2005 Dec 1; 63(5):1483-7. PMID: 16099600.
    View in: PubMed
  25. Jahraus CD, Glisson SD, St Clair WH. Treatment of desmoplastic small round cell tumor with image-guided intensity modulated radiation therapy as a component of multimodality treatment. Tumori. 2005 May-Jun; 91(3):253-5. PMID: 16206650.
    View in: PubMed
  26. Zhao Y, Chaiswing L, Oberley TD, Batinic-Haberle I, St Clair W, Epstein CJ, St Clair D. A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. Cancer Res. 2005 Feb 15; 65(4):1401-5. PMID: 15735027.
    View in: PubMed
  27. Jahraus CD, Russo S, Peñagarícano J, Routh A, St Clair W. Radiotherapy dose fractionation in pediatric Langerhans cell histiocytosis. South Med J. 2004 Dec; 97(12):1268-9. PMID: 15646770.
    View in: PubMed
  28. Jahraus CD, St Clair W, Gurley J, Meigooni AS. Endovascular brachytherapy for the treatment of renal artery in-stent restenosis using a beta-emitting source: a report of five patients. South Med J. 2003 Nov; 96(11):1165-8. PMID: 14632372.
    View in: PubMed
  29. St Clair DK, Oberley TD, Muse KE, St Clair WH. Expression of manganese superoxide dismutase promotes cellular differentiation. Free Radic Biol Med. 1994 Feb; 16(2):275-82. PMID: 7516302.
    View in: PubMed
  30. St Clair DK, Wan XS, Oberley TD, Muse KE, St Clair WH. Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase. Mol Carcinog. 1992; 6(4):238-42. PMID: 1485915.
    View in: PubMed
  31. ST CLAIR WH. Thyroidectomy. Am Surg. 1952 Mar; 18(3):245-53. PMID: 14903538.
    View in: PubMed