Frederick A. Schmitt, PhD

Clinical interests

  • Alzheimer's Disease
  • Biostatistics
  • Clinical Trials
  • Dementia
  • Epilepsy
  • HIV
  • Memory Disorders
  • Neurocognition

Frederick A. Schmitt, PhD

Biography

Dr. Frederick Schmitt received his doctoral degree and completed a fellowship at the University of Akron, Ohio. His clinical interests include biostatistics, dementia and HIV. Schmitt is the Mary Carter Award recipient for his work with patients with Downs Syndrome and neurodegenerative disease, and is a nationally and internationally renowned expert on neurodegenerative conditions including Alzheimer's disease. He is a principal investigator and consultant on numerous grants from the NIH and other federal and state funding mechanisms. He has over 30 years of clinical experience in neurocognition.

Faculty rank

Professor of Neurology, Neurosurgery, Psychiatry, Behavioral Science, and Psychology

Education

Degree
University of Akron, Ohio

Residency
Duke University Medical Center, Durham, N.C.

Fellowship
University of Akron, Ohio

Neurology

Kentucky Neuroscience Institute

Kentucky Clinic
First Floor, Wing C, Room B101
740 S. Limestone
Lexington KY 40536-0284

Call 859-323-5661
Fax 859-323-3753

Amenities
Dining, Internet/Wi-Fi, Information desk, Pharmacy services, Wheelchairs

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  1. Abner EL, Nelson PT, Kryscio RJ, Schmitt FA, Fardo DW, Woltjer RL, Cairns NJ, Yu L, Dodge HH, Xiong C, Masaki K, Tyas SL, Bennett DA, Schneider JA, Arvanitakis Z. Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology. Alzheimers Dement. 2016 Aug;12(8):882-9.
    View in: PubMed
  2. Nelson PT, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang WX, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET. "New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS). J Neuropathol Exp Neurol. 2016 Jun;75(6):482-98.
    View in: PubMed
  3. Wilcock DM, Schmitt FA, Head E. Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome. Biochim Biophys Acta. 2016 May;1862(5):909-14.
    View in: PubMed
  4. Cykowski MD, Takei H, Van Eldik LJ, Schmitt FA, Jicha GA, Powell SZ, Nelson PT. Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons. J Neuropathol Exp Neurol. 2016 May;75(5):397-407.
    View in: PubMed
  5. Anderson-Mooney AJ, Schmitt FA, Head E, Lott IT, Heilman KM. Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms. Brain Cogn. 2016 Apr;104:48-57.
    View in: PubMed
  6. Kryscio RJ, Abner EL, Schmitt FA, Goodman PJ, Mendiondo M, Caban-Holt A, Dennis BC, Mathews M, Klein EA, Crowley JJ. A Randomized Controlled Alzheimer's Disease Prevention Trial's Evolution into an Exposure Trial: The PREADViSE Trial. J Nutr Health Aging. 2013; 17(1):72-5. PMID: 23299383.
    View in: PubMed
  7. Neltner JH, Abner EL, Schmitt FA, Denison SK, Anderson S, Patel E, Nelson PT. Digital pathology and image analysis for robust high-throughput quantitative assessment of Alzheimer disease neuropathologic changes. J Neuropathol Exp Neurol. 2012 Dec; 71(12):1075-85. PMID: 23147505.
    View in: PubMed
  8. Abner EL, Dennis BC, Mathews MJ, Mendiondo MS, Caban-Holt A, Kryscio RJ, Schmitt FA. Practice effects in a longitudinal, multi-center Alzheimer's disease prevention clinical trial. Trials. 2012; 13:217. PMID: 23171483.
    View in: PubMed
  9. Sudduth TL, Schmitt FA, Nelson PT, Wilcock DM. Neuroinflammatory phenotype in early Alzheimer's disease. Neurobiol Aging. 2013 Apr; 34(4):1051-9. PMID: 23062700.
    View in: PubMed
  10. Schmitt FA, Nelson PT, Abner E, Scheff S, Jicha GA, Smith C, Cooper G, Mendiondo M, Danner DD, Van Eldik LJ, Caban-Holt A, Lovell MA, Kryscio RJ. University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology. Curr Alzheimer Res. 2012 Jul; 9(6):724-33. PMID: 22471862.
    View in: PubMed
  11. Kruger TM, Abner EL, Mendiondo M, Schmitt FA, Smith CD, Jicha GA. Differential reports of pain and depression differentiate mild cognitive impairment from cognitively intact elderly participants. J Geriatr Psychiatry Neurol. 2012 Jun; 25(2):107-12. PMID: 22689703.
    View in: PubMed
  12. Caban-Holt A, Abner E, Kryscio RJ, Crowley JJ, Schmitt FA. Age-expanded normative data for the Ruff 2&7 Selective Attention Test: evaluating cognition in older males. Clin Neuropsychol. 2012; 26(5):751-68. PMID: 22651854.
    View in: PubMed
  13. Abner EL, Kryscio RJ, Cooper GE, Fardo DW, Jicha GA, Mendiondo MS, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA. Mild cognitive impairment: statistical models of transition using longitudinal clinical data. Int J Alzheimers Dis. 2012; 2012:291920. PMID: 22536535.
    View in: PubMed
  14. Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, Lott IT, Schmitt FA, Butterfield DA, Head E. Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochim Biophys Acta. 2012 Feb; 1822(2):130-8. PMID: 22009041.
    View in: PubMed
  15. Abner EL, Schmitt FA, Mendiondo MS, Marcum JL, Kryscio RJ. Vitamin E and all-cause mortality: a meta-analysis. Curr Aging Sci. 2011 Jul; 4(2):158-70. PMID: 21235492.
    View in: PubMed
  16. Ferris SH, Schmitt FA, Saxton J, Richardson S, Mackell J, Sun Y, Xu Y. Analyzing the impact of 23 mg/day donepezil on language dysfunction in moderate to severe Alzheimer's disease. Alzheimers Res Ther. 2011; 3(3):22. PMID: 21689411.
    View in: PubMed
  17. Nelson PT, Schmitt FA, Lin Y, Abner EL, Jicha GA, Patel E, Thomason PC, Neltner JH, Smith CD, Santacruz KS, Sonnen JA, Poon LW, Gearing M, Green RC, Woodard JL, Van Eldik LJ, Kryscio RJ. Hippocampal sclerosis in advanced age: clinical and pathological features. Brain. 2011 May; 134(Pt 5):1506-18. PMID: 21596774.
    View in: PubMed
  18. Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol. 2011 May; 121(5):571-87. PMID: 21516511.
    View in: PubMed
  19. Jicha GA, Abner EL, Schmitt FA, Kryscio RJ, Riley KP, Cooper GE, Stiles N, Mendiondo MS, Smith CD, Van Eldik LJ, Nelson PT. Preclinical AD Workgroup staging: pathological correlates and potential challenges. Neurobiol Aging. 2012 Mar; 33(3):622.e1-622.e16. PMID: 21507528.
    View in: PubMed
  20. Alva G, Grossberg GT, Schmitt FA, Meng X, Olin JT. Efficacy of rivastigmine transdermal patch on activities of daily living: item responder analyses. Int J Geriatr Psychiatry. 2011 Apr; 26(4):356-63. PMID: 21312297.
    View in: PubMed
  21. Abner EL, Kryscio RJ, Schmitt FA, Santacruz KS, Jicha GA, Lin Y, Neltner JM, Smith CD, Van Eldik LJ, Nelson PT. "End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction? J Alzheimers Dis. 2011; 25(3):445-53. PMID: 21471646.
    View in: PubMed
  22. Riley KP, Jicha GA, Davis D, Abner EL, Cooper GE, Stiles N, Smith CD, Kryscio RJ, Nelson PT, Van Eldik LJ, Schmitt FA. Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition. J Alzheimers Dis. 2011; 25(4):707-17. PMID: 21498903.
    View in: PubMed
  23. Scheff SW, Price DA, Schmitt FA, Scheff MA, Mufson EJ. Synaptic loss in the inferior temporal gyrus in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2011; 24(3):547-57. PMID: 21297265.
    View in: PubMed
  24. Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT. Plasma amyloid-ß as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. J Alzheimers Dis. 2011; 23(3):399-409. PMID: 21116050.
    View in: PubMed
  25. Grossberg GT, Schmitt FA, Meng X, Tekin S, Olin J. Reviews: Effects of transdermal rivastigmine on ADAS-cog items in mild-to-moderate Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2010 Dec; 25(8):627-33. PMID: 21131668.
    View in: PubMed
  26. McLaughlin T, Feldman H, Fillit H, Sano M, Schmitt F, Aisen P, Leibman C, Mucha L, Ryan JM, Sullivan SD, Spackman DE, Neumann PJ, Cohen J, Stern Y. Dependence as a unifying construct in defining Alzheimer's disease severity. Alzheimers Dement. 2010 Nov; 6(6):482-93. PMID: 21044778.
    View in: PubMed
  27. Schmitt FA, Farlow MR, Meng X, Tekin S, Olin JT. Efficacy of rivastigmine on executive function in patients with Parkinson's disease dementia. CNS Neurosci Ther. 2010 Dec; 16(6):330-6. PMID: 20950329.
    View in: PubMed
  28. Nelson PT, Schmitt FA, Jicha GA, Kryscio RJ, Abner EL, Smith CD, Van Eldik LJ, Markesbery WR. Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol. 2010 Nov; 257(11):1875-81. PMID: 20563821.
    View in: PubMed
  29. Schmitt FA, Aarsland D, Brønnick KS, Meng X, Tekin S, Olin JT. Evaluating rivastigmine in mild-to-moderate Parkinson's disease dementia using ADAS-cog items. Am J Alzheimers Dis Other Demen. 2010 Aug; 25(5):407-13. PMID: 20392860.
    View in: PubMed
  30. Carr SA, Davis R, Spencer D, Smart M, Hudson J, Freeman S, Cooper GE, Schmitt FA, Markesbery WR, Danner D, Jicha GA. Comparison of recruitment efforts targeted at primary care physicians versus the community at large for participation in Alzheimer disease clinical trials. Alzheimer Dis Assoc Disord. 2010 Apr-Jun; 24(2):165-70. PMID: 19571728.
    View in: PubMed
  31. Locke DE, Fakhoury TA, Berry DT, Locke TR, Schmitt FA. Objective evaluation of personality and psychopathology in temporal lobe versus extratemporal lobe epilepsy. Epilepsy Behav. 2010 Feb; 17(2):172-7. PMID: 20022813.
    View in: PubMed
  32. Grear KE, Ling IF, Simpson JF, Furman JL, Simmons CR, Peterson SL, Schmitt FA, Markesbery WR, Liu Q, Crook JE, Younkin SG, Bu G, Estus S. Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Mol Neurodegener. 2009; 4:46. PMID: 19889229.
    View in: PubMed
  33. Nelson PT, Kryscio RJ, Jicha GA, Abner EL, Schmitt FA, Xu LO, Cooper G, Smith CD, Markesbery WR. Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies. Neurology. 2009 Oct 6; 73(14):1127-33. PMID: 19805729.
    View in: PubMed
  34. Nelson PT, Jicha GA, Kryscio RJ, Abner EL, Schmitt FA, Cooper G, Xu LO, Smith CD, Markesbery WR. Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol. 2010 Mar; 257(3):359-66. PMID: 19795154.
    View in: PubMed
  35. Schmitt FA, Saxton JA, Xu Y, McRae T, Sun Y, Richardson S, Li H. A brief instrument to assess treatment response in the patient with advanced Alzheimer disease. Alzheimer Dis Assoc Disord. 2009 Oct-Dec; 23(4):377-83. PMID: 19571727.
    View in: PubMed
  36. Hoffmann M, Schmitt F, Bromley E. Vascular cognitive syndromes: relation to stroke etiology and topography. Acta Neurol Scand. 2009 Sep; 120(3):161-9. PMID: 19486324.
    View in: PubMed
  37. Schneider LS, Raman R, Schmitt FA, Doody RS, Insel P, Clark CM, Morris JC, Reisberg B, Petersen RC, Ferris SH. Characteristics and performance of a modified version of the ADCS-CGIC CIBIC+ for mild cognitive impairment clinical trials. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):260-7. PMID: 19812469.
    View in: PubMed
  38. Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Santacruz K, Smith CD, Patel E, Markesbery WR. Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease. J Neuropathol Exp Neurol. 2009 Jul; 68(7):774-84. PMID: 19535994.
    View in: PubMed
  39. Markesbery WR, Jicha GA, Liu H, Schmitt FA. Lewy body pathology in normal elderly subjects. J Neuropathol Exp Neurol. 2009 Jul; 68(7):816-22. PMID: 19535990.
    View in: PubMed
  40. Price JL, McKeel DW, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC. Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging. 2009 Jul; 30(7):1026-36. PMID: 19376612.
    View in: PubMed
  41. Nelson PT, Kryscio RJ, Abner EL, Schmitt FA, Jicha GA, Mendiondo MS, Cooper G, Smith CB, Markesbery WR. Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB. J Alzheimers Dis. 2009; 16(1):29-34. PMID: 19158418.
    View in: PubMed
  42. Dassel KB, Schmitt FA. The impact of caregiver executive skills on reports of patient functioning. Gerontologist. 2008 Dec; 48(6):781-92. PMID: 19139251.
    View in: PubMed
  43. Hoffmann M, Schmitt F, Bromley E. Comprehensive cognitive neurological assessment in stroke. Acta Neurol Scand. 2009 Mar; 119(3):162-71. PMID: 19053949.
    View in: PubMed
  44. Jicha GA, Schmitt FA, Abner E, Nelson PT, Cooper GE, Smith CD, Markesbery WR. Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease. Neurobiol Aging. 2010 Oct; 31(10):1805-13. PMID: 19026468.
    View in: PubMed
  45. Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Davis DG, Poduska JW, Patel E, Mendiondo MS, Markesbery WR. Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol. 2010 Jan; 20(1):66-79. PMID: 19021630.
    View in: PubMed
  46. Nelson PT, Abner EL, Scheff SW, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Patel E, Markesbery WR. Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment. Neurosci Lett. 2009 Feb 6; 450(3):336-9. PMID: 19010392.
    View in: PubMed
  47. Martin SB, Smith CD, Collins HR, Schmitt FA, Gold BT. Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment. Neurobiol Aging. 2010 Jul; 31(7):1099-106. PMID: 18809227.
    View in: PubMed
  48. Jicha GA, Abner E, Schmitt FA, Cooper GE, Stiles N, Hamon R, Carr S, Smith CD, Markesbery WR. Clinical features of mild cognitive impairment differ in the research and tertiary clinic settings. Dement Geriatr Cogn Disord. 2008; 26(2):187-92. PMID: 18724049.
    View in: PubMed
  49. Nelson PT, Smith CD, Abner EA, Schmitt FA, Scheff SW, Davis GJ, Keller JN, Jicha GA, Davis D, Wang-Xia W, Hartman A, Katz DG, Markesbery WR. Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim Biophys Acta. 2009 May; 1792(5):454-69. PMID: 18789386.
    View in: PubMed
  50. Nelson PT, Jicha GA, Schmitt FA, Liu H, Davis DG, Mendiondo MS, Abner EL, Markesbery WR. Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J Neuropathol Exp Neurol. 2007 Dec; 66(12):1136-46. PMID: 18090922.
    View in: PubMed
  51. Bottiggi KA, Chang JJ, Schmitt FA, Avison MJ, Mootoor Y, Nath A, Berger JR. The HIV Dementia Scale: predictive power in mild dementia and HAART. J Neurol Sci. 2007 Sep 15; 260(1-2):11-5. PMID: 17482212.
    View in: PubMed
  52. Scheff SW, Price DA, Schmitt FA, DeKosky ST, Mufson EJ. Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology. 2007 May 1; 68(18):1501-8. PMID: 17470753.
    View in: PubMed
  53. Weycker D, Taneja C, Edelsberg J, Erder MH, Schmitt FA, Setyawan J, Oster G. Cost-effectiveness of memantine in moderate-to-severe Alzheimer's disease patients receiving donepezil. Curr Med Res Opin. 2007 May; 23(5):1187-97. PMID: 17519086.
    View in: PubMed
  54. Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Jicha GA, Cooper G, Markesbery WR. Brain structural alterations before mild cognitive impairment. Neurology. 2007 Apr 17; 68(16):1268-73. PMID: 17438217.
    View in: PubMed
  55. Ashford JW, Borson S, O'Hara R, Dash P, Frank L, Robert P, Shankle WR, Tierney MC, Brodaty H, Schmitt FA, Kraemer HC, Buschke H, Fillit H. Should older adults be screened for dementia? It is important to screen for evidence of dementia! Alzheimers Dement. 2007 Apr; 3(2):75-80. PMID: 19595920.
    View in: PubMed
  56. Bottiggi KA, Salazar JC, Yu L, Caban-Holt AM, Ryan M, Schmitt FA. Concomitant use of medications with anticholinergic properties and acetylcholinesterase inhibitors: impact on cognitive and physical functioning in Alzheimer disease. Am J Geriatr Psychiatry. 2007 Apr; 15(4):357-9. PMID: 17384320.
    View in: PubMed
  57. Nelson KR, Mattingly M, Schmitt FA. Out-of-body experience and arousal. Neurology. 2007 Mar 6; 68(10):794-5. PMID: 17339596.
    View in: PubMed
  58. Salazar JC, Schmitt FA, Yu L, Mendiondo MM, Kryscio RJ. Shared random effects analysis of multi-state Markov models: application to a longitudinal study of transitions to dementia. Stat Med. 2007 Feb 10; 26(3):568-80. PMID: 16345024.
    View in: PubMed
  59. Schmitt F, Ryan M, Cooper G. A brief review of the pharmacologic and therapeutic aspects of memantine in Alzheimer's disease. Expert Opin Drug Metab Toxicol. 2007 Feb; 3(1):135-41. PMID: 17269900.
    View in: PubMed
  60. Bottiggi KA, Salazar JC, Yu L, Caban-Holt AM, Ryan M, Mendiondo MS, Schmitt FA. Long-term cognitive impact of anticholinergic medications in older adults. Am J Geriatr Psychiatry. 2006 Nov; 14(11):980-4. PMID: 17068321.
    View in: PubMed
  61. Feldman HH, Schmitt FA, Olin JT. Activities of daily living in moderate-to-severe Alzheimer disease: an analysis of the treatment effects of memantine in patients receiving stable donepezil treatment. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4):263-8. PMID: 17132971.
    View in: PubMed
  62. Schmitt FA, van Dyck CH, Wichems CH, Olin JT. Cognitive response to memantine in moderate to severe Alzheimer disease patients already receiving donepezil: an exploratory reanalysis. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4):255-62. PMID: 17132970.
    View in: PubMed
  63. Schneider LS, Clark CM, Doody R, Ferris SH, Morris JC, Raman R, Reisberg B, Schmitt FA. ADCS Prevention Instrument Project: ADCS-clinicians' global impression of change scales (ADCS-CGIC), self-rated and study partner-rated versions. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S124-38. PMID: 17135806.
    View in: PubMed
  64. Mitchell DB, Schmitt FA. Short- and long-term implicit memory in aging and Alzheimer's disease. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2006 Sep-Dec; 13(3-4):611-35. PMID: 16887792.
    View in: PubMed
  65. Cragar DE, Berry DT, Fakhoury TA, Cibula JE, Schmitt FA. Performance of patients with epilepsy or psychogenic non-epileptic seizures on four measures of effort. Clin Neuropsychol. 2006 Sep; 20(3):552-66. PMID: 16895866.
    View in: PubMed
  66. Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Markesbery WR. Age and gender effects on human brain anatomy: a voxel-based morphometric study in healthy elderly. Neurobiol Aging. 2007 Jul; 28(7):1075-87. PMID: 16774798.
    View in: PubMed
  67. Hoffmann M, Schmitt F. Metacognition in stroke: bedside assessment and relation to location, size, and stroke severity. Cogn Behav Neurol. 2006 Jun; 19(2):85-94. PMID: 16783131.
    View in: PubMed
  68. van Dyck CH, Schmitt FA, Olin JT. A responder analysis of memantine treatment in patients with Alzheimer disease maintained on donepezil. Am J Geriatr Psychiatry. 2006 May; 14(5):428-37. PMID: 16670247.
    View in: PubMed
  69. Nelson KR, Mattingly M, Lee SA, Schmitt FA. Does the arousal system contribute to near death experience? Neurology. 2006 Apr 11; 66(7):1003-9. PMID: 16606911.
    View in: PubMed
  70. Ashford JW, Borson S, O'Hara R, Dash P, Frank L, Robert P, Shankle WR, Tierney MC, Brodaty H, Schmitt FA, Kraemer HC, Buschke H. Should older adults be screened for dementia? Alzheimers Dement. 2006 Apr; 2(2):76-85. PMID: 19595860.
    View in: PubMed
  71. Locke DE, Berry DT, Fakhoury TA, Schmitt FA. Relationship of indicators of neuropathology, psychopathology, and effort to neuropsychological results in patients with epilepsy or psychogenic non-epileptic seizures. J Clin Exp Neuropsychol. 2006 Apr; 28(3):325-40. PMID: 16618623.
    View in: PubMed
  72. Kryscio RJ, Schmitt FA, Salazar JC, Mendiondo MS, Markesbery WR. Risk factors for transitions from normal to mild cognitive impairment and dementia. Neurology. 2006 Mar 28; 66(6):828-32. PMID: 16567698.
    View in: PubMed
  73. Espinosa PS, Kryscio RJ, Mendiondo MS, Schmitt FA, Wekstein DR, Markesbery WR, Smith CD. Alzheimer's disease and head circumference. J Alzheimers Dis. 2006 Mar; 9(1):77-80. PMID: 16627937.
    View in: PubMed
  74. Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR. Neuropathologic substrate of mild cognitive impairment. Arch Neurol. 2006 Jan; 63(1):38-46. PMID: 16401735.
    View in: PubMed
  75. Reisberg B, Doody R, Stöffler A, Schmitt F, Ferris S, Möbius HJ. A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease. Arch Neurol. 2006 Jan; 63(1):49-54. PMID: 16401736.
    View in: PubMed
  76. Schmitt FA, Wichems CH. A systematic review of assessment and treatment of moderate to severe Alzheimer's disease. Prim Care Companion J Clin Psychiatry. 2006; 8(3):158-9. PMID: 16912819.
    View in: PubMed
  77. Donovan KA, Small BJ, Andrykowski MA, Schmitt FA, Munster P, Jacobsen PB. Cognitive functioning after adjuvant chemotherapy and/or radiotherapy for early-stage breast carcinoma. Cancer. 2005 Dec 1; 104(11):2499-507. PMID: 16247788.
    View in: PubMed
  78. Scheff SW, Price DA, Schmitt FA, Mufson EJ. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol Aging. 2006 Oct; 27(10):1372-84. PMID: 16289476.
    View in: PubMed
  79. Smith CD, Kryscio RJ, Schmitt FA, Lovell MA, Blonder LX, Rayens WS, Andersen AH. Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease. J Neuroimaging. 2005 Jul; 15(3):271-7. PMID: 15951411.
    View in: PubMed
  80. Galasko D, Schmitt F, Thomas R, Jin S, Bennett D. Detailed assessment of activities of daily living in moderate to severe Alzheimer's disease. J Int Neuropsychol Soc. 2005 Jul; 11(4):446-53. PMID: 16209425.
    View in: PubMed
  81. Caban-Holt A, Bottiggi K, Schmitt FA. Measuring treatment response in Alzheimer's disease clinical trials. Geriatrics. 2005 Jun; Suppl:3-8. PMID: 16025769.
    View in: PubMed
  82. Caban-Holt A, Mattingly M, Cooper G, Schmitt FA. Neurodegenerative memory disorders: a potential role of environmental toxins. Neurol Clin. 2005 May; 23(2):485-521. PMID: 15757794.
    View in: PubMed
  83. Cragar DE, Berry DT, Schmitt FA, Fakhoury TA. Cluster analysis of normal personality traits in patients with psychogenic nonepileptic seizures. Epilepsy Behav. 2005 Jun; 6(4):593-600. PMID: 15907754.
    View in: PubMed
  84. Keller JN, Schmitt FA, Scheff SW, Ding Q, Chen Q, Butterfield DA, Markesbery WR. Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology. 2005 Apr 12; 64(7):1152-6. PMID: 15824339.
    View in: PubMed
  85. Avison MJ, Nath A, Greene-Avison R, Schmitt FA, Greenberg RN, Berger JR. Neuroimaging correlates of HIV-associated BBB compromise. J Neuroimmunol. 2004 Dec; 157(1-2):140-6. PMID: 15579291.
    View in: PubMed
  86. Gaugler JE, Anderson KA, Leach MS, Smith CD, Schmitt FA, Mendiondo M. The emotional ramifications of unmet need in dementia caregiving. Am J Alzheimers Dis Other Demen. 2004 Nov-Dec; 19(6):369-80. PMID: 15633946.
    View in: PubMed
  87. Avison MJ, Nath A, Greene-Avison R, Schmitt FA, Bales RA, Ethisham A, Greenberg RN, Berger JR. Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia. J Neurovirol. 2004 Aug; 10(4):223-32. PMID: 15371152.
    View in: PubMed
  88. Doody R, Wirth Y, Schmitt F, Möbius HJ. Specific functional effects of memantine treatment in patients with moderate to severe Alzheimer's disease. Dement Geriatr Cogn Disord. 2004; 18(2):227-32. PMID: 15256834.
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  89. Regine WF, Schmitt FA, Scott CB, Dearth C, Patchell RA, Nichols RC, Gore EM, Franklin RL, Suh JH, Mehta MP. Feasibility of neurocognitive outcome evaluations in patients with brain metastases in a multi-institutional cooperative group setting: results of Radiation Therapy Oncology Group trial BR-0018. Int J Radiat Oncol Biol Phys. 2004 Apr 1; 58(5):1346-52. PMID: 15050309.
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  90. Kryscio RJ, Mendiondo MS, Schmitt FA, Markesbery WR. Designing a large prevention trial: statistical issues. Stat Med. 2004 Jan 30; 23(2):285-96. PMID: 14716729.
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  91. Hoffmann M, Schmitt F. Cognitive impairment in isolated subtentorial stroke. Acta Neurol Scand. 2004 Jan; 109(1):14-24. PMID: 14653846.
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  92. Mendiondo MS, Ashford JW, Kryscio RJ, Schmitt FA. Designing a Brief Alzheimer Screen (BAS). J Alzheimers Dis. 2003 Oct; 5(5):391-8. PMID: 14646030.
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  93. Cragar DE, Schmitt FA, Berry DT, Cibula JE, Dearth CM, Fakhoury TA. A comparison of MMPI-2 decision rules in the diagnosis of nonepileptic seizures. J Clin Exp Neuropsychol. 2003 Sep; 25(6):793-804. PMID: 13680457.
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  94. Gaugler JE, Mendiondo M, Smith CD, Schmitt FA. Secondary dementia caregiving and its consequences. Am J Alzheimers Dis Other Demen. 2003 Sep-Oct; 18(5):300-8. PMID: 14569647.
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  95. Pulliam JF, Jennings CD, Kryscio RJ, Davis DG, Wilson D, Montine TJ, Schmitt FA, Markesbery WR. Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE. Am J Med Genet B Neuropsychiatr Genet. 2003 May 15; 119B(1):48-53. PMID: 12707938.
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  96. Reisberg B, Doody R, Stöffler A, Schmitt F, Ferris S, Möbius HJ. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med. 2003 Apr 3; 348(14):1333-41. PMID: 12672860.
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  97. Gaugler JE, Wackerbarth SB, Mendiondo M, Schmitt FA, Smith CD. The characteristics of dementia caregiving onset. Am J Alzheimers Dis Other Demen. 2003 Mar-Apr; 18(2):97-104. PMID: 12708225.
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  98. Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ. Women at risk for AD show increased parietal activation during a fluency task. Neurology. 2002 Apr 23; 58(8):1197-202. PMID: 11971086.
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  99. Cragar DE, Berry DT, Fakhoury TA, Cibula JE, Schmitt FA. A review of diagnostic techniques in the differential diagnosis of epileptic and nonepileptic seizures. Neuropsychol Rev. 2002 Mar; 12(1):31-64. PMID: 12090718.
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  100. Schmitt FA, Cragar D, Ashford JW, Reisberg B, Ferris S, Möbius HJ, Stöffler A. Measuring cognition in advanced Alzheimer's disease for clinical trials. J Neural Transm Suppl. 2002; (62):135-48. PMID: 12456059.
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  101. Schmitt FA, Wetherby MM, Wekstein DR, Dearth CM, Markesbery WR. Brain donation in normal aging: procedures, motivations, and donor characteristics from the Biologically Resilient Adults in Neurological Studies (BRAiNS) Project. Gerontologist. 2001 Dec; 41(6):716-22. PMID: 11723339.
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  102. Jaksch M, Lochmuller H, Schmitt F, Volpel B, Obermaier-Kusser B, Horvath R. A mutation in mt tRNALeu(UUR) causing a neuropsychiatric syndrome with depression and cataract. Neurology. 2001 Nov 27; 57(10):1930-1. PMID: 11723298.
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  103. Mendiondo MS, Kryscio RJ, Schmitt FA. Models of progression in AD: predicting disability and costs. Neurology. 2001 Sep 25; 57(6):943-4. PMID: 11571313.
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  104. Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ. Differences in functional magnetic resonance imaging activation by category in a visual confrontation naming task. J Neuroimaging. 2001 Apr; 11(2):165-70. PMID: 11296587.
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  105. Ashford JW, Schmitt FA. Modeling the time-course of Alzheimer dementia. Curr Psychiatry Rep. 2001 Feb; 3(1):20-8. PMID: 11177755.
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  106. Nath A, Maragos WF, Avison MJ, Schmitt FA, Berger JR. Acceleration of HIV dementia with methamphetamine and cocaine. J Neurovirol. 2001 Feb; 7(1):66-71. PMID: 11519485.
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  107. Schmitt FA, Davis DG, Wekstein DR, Smith CD, Ashford JW, Markesbery WR. "Preclinical" AD revisited: neuropathology of cognitively normal older adults. Neurology. 2000 Aug 8; 55(3):370-6. PMID: 10932270.
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  108. Karlawish JH, Schmitt FA. Why physicians need to become more proficient in assessing their patients' competency and how they can achieve this. J Am Geriatr Soc. 2000 Aug; 48(8):1014-6. PMID: 10968311.
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  109. Schmitt FA, Miller JP, Kryscio RJ. Promoting interactions with basic scientists and clinicians: summary of the panel session. Stat Med. 2000 Jun 15-30; 19(11-12):1463-8. PMID: 10844711.
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  110. Mendiondo MS, Ashford JW, Kryscio RJ, Schmitt FA. Modelling mini mental state examination changes in Alzheimer's disease. Stat Med. 2000 Jun 15-30; 19(11-12):1607-16. PMID: 10844722.
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  111. Ashford JW, Shih WJ, Coupal J, Shetty R, Schneider A, Cool C, Aleem A, Kiefer VH, Mendiondo MS, Schmitt FA. Single SPECT measures of cerebral cortical perfusion reflect time-index estimation of dementia severity in Alzheimer's disease. J Nucl Med. 2000 Jan; 41(1):57-64. PMID: 10647605.
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  112. Smith CD, Umberger GH, Manning EL, Slevin JT, Wekstein DR, Schmitt FA, Markesbery WR, Zhang Z, Gerhardt GA, Kryscio RJ, Gash DM. Critical decline in fine motor hand movements in human aging. Neurology. 1999 Oct 22; 53(7):1458-61. PMID: 10534251.
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  113. Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ. Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease. Neurology. 1999 Oct 22; 53(7):1391-6. PMID: 10534240.
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  114. Davis DG, Schmitt FA, Wekstein DR, Markesbery WR. Alzheimer neuropathologic alterations in aged cognitively normal subjects. J Neuropathol Exp Neurol. 1999 Apr; 58(4):376-88. PMID: 10218633.
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  115. Saxe SR, Wekstein MW, Kryscio RJ, Henry RG, Cornett CR, Snowdon DA, Grant FT, Schmitt FA, Donegan SJ, Wekstein DR, Ehmann WD, Markesbery WR. Alzheimer's disease, dental amalgam and mercury. J Am Dent Assoc. 1999 Feb; 130(2):191-9. PMID: 10036842.
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  116. Smith CD, Malcein M, Meurer K, Schmitt FA, Markesbery WR, Pettigrew LC. MRI temporal lobe volume measures and neuropsychologic function in Alzheimer's disease. J Neuroimaging. 1999 Jan; 9(1):2-9. PMID: 9922716.
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  117. Blonder LX, Hodes JE, Ranseen JD, Schmitt FA. Short-term neuropsychological outcome following Gamma Knife radiosurgery for arteriovenous malformations: a preliminary report. Appl Neuropsychol. 1999; 6(3):181-6. PMID: 10497695.
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  118. Piecoro LT, Wermeling DP, Schmitt FA, Ashford JW. Seizures in patients receiving concomitant antimuscarinics and acetylcholinesterase inhibitor. Pharmacotherapy. 1998 Sep-Oct; 18(5):1129-32. PMID: 9758325.
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  119. Pettigrew LC, Bieber F, Lettieri J, Wermeling DP, Schmitt FA, Tikhtman AJ, Ashford JW, Smith CD, Wekstein DR, Markesbery WR, Orazem J, Ruzicka BB, Mas J, Gulanski B. Pharmacokinetics, pharmacodynamics, and safety of metrifonate in patients with Alzheimer's disease. J Clin Pharmacol. 1998 Mar; 38(3):236-45. PMID: 9549662.
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  120. Ferris SH, Mackell JA, Mohs R, Schneider LS, Galasko D, Whitehouse PJ, Schmitt FA, Sano M, Thomas RG, Ernesto C, Grundman M, Schafer K, Thal LJ. A multicenter evaluation of new treatment efficacy instruments for Alzheimer's disease clinical trials: overview and general results. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord. 1997; 11 Suppl 2:S1-12. PMID: 9236947.
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  121. Schneider LS, Olin JT, Doody RS, Clark CM, Morris JC, Reisberg B, Schmitt FA, Grundman M, Thomas RG, Ferris SH. Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord. 1997; 11 Suppl 2:S22-32. PMID: 9236949.
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  122. Mackell JA, Ferris SH, Mohs R, Schneider L, Galasko D, Whitehouse P, Schmitt F, Sano M, Thal LJ. Multicenter evaluation of new instruments for Alzheimer's disease clinical trials: summary of results. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord. 1997; 11 Suppl 2:S65-9. PMID: 9236955.
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  123. Schmitt FA, Ashford W, Ernesto C, Saxton J, Schneider LS, Clark CM, Ferris SH, Mackell JA, Schafer K, Thal LJ. The severe impairment battery: concurrent validity and the assessment of longitudinal change in Alzheimer's disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord. 1997; 11 Suppl 2:S51-6. PMID: 9236953.
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  124. Olin JT, Schneider LS, Doody RS, Clark CM, Ferris SH, Morris JC, Reisberg B, Schmitt FA. Clinical evaluation of global change in Alzheimer's disease: identifying consensus. J Geriatr Psychiatry Neurol. 1996 Oct; 9(4):176-80. PMID: 8970010.
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  125. Kulkarni-Narla A, Getchell TV, Schmitt FA, Getchell ML. Manganese and copper-zinc superoxide dismutases in the human olfactory mucosa: increased immunoreactivity in Alzheimer's disease. Exp Neurol. 1996 Aug; 140(2):115-25. PMID: 8690055.
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  126. Schmitt FA, Phillips BA, Cook YR, Berry DT, Wekstein DR. Self report on sleep symptoms in older adults: correlates of daytime sleepiness and health. Sleep. 1996 Jan; 19(1):59-64. PMID: 8650465.
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  127. Greiner PA, Snowdon DA, Schmitt FA. The loss of independence in activities of daily living: the role of low normal cognitive function in elderly nuns. Am J Public Health. 1996 Jan; 86(1):62-6. PMID: 8561244.
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  128. Ashford JW, Shan M, Butler S, Rajasekar A, Schmitt FA. Temporal quantification of Alzheimer's disease severity: 'time index' model. Dementia. 1995 Sep-Oct; 6(5):269-80. PMID: 8528374.
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  129. Smith CD, Pettigrew LC, Avison MJ, Kirsch JE, Tinkhtman AJ, Schmitt FA, Wermeling DP, Wekstein DR, Markesberry WR. Frontal lobe phosphorus metabolism and neuropsychological function in aging and in Alzheimer's disease. Ann Neurol. 1995 Aug; 38(2):194-201. PMID: 7654066.
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  130. Phillips BA, Berry DT, Schmitt FA, Harbison L, Lipke-Molby T. Sleep-disordered breathing in healthy aged persons: two- and three-year follow-up. Sleep. 1994 Aug; 17(5):411-5. PMID: 7991951.
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  131. Berry DT, Carpenter GS, Campbell DA, Schmitt FA, Helton K, Lipke-Molby T. The New Adult Reading Test-Revised: accuracy in estimating WAIS-R IQ scores obtained 3.5 years earlier from normal older persons. Arch Clin Neuropsychol. 1994 May; 9(3):239-50. PMID: 14589578.
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  132. Marson DC, Schmitt FA, Ingram KK, Harrell LE. Determining the competency of Alzheimer patients to consent to treatment and research. Alzheimer Dis Assoc Disord. 1994; 8 Suppl 4:5-18. PMID: 7695856.
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  133. Lanska DJ, Schmitt FA, Stewart JM, Howe JN. Telephone-Assessed Mental State. Dementia. 1993 Mar-Apr; 4(2):117-9. PMID: 8358512.
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  134. Logue PE, Tupler LA, D'Amico C, Schmitt FA. The Neurobehavioral Cognitive Status Examination: psychometric properties in use with psychiatric inpatients. J Clin Psychol. 1993 Jan; 49(1):80-9. PMID: 8425938.
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  135. Van Gorp WG, Lamb DG, Schmitt FA. Methodologic issues in neuropsychological research with HIV-spectrum disease. Arch Clin Neuropsychol. 1993 Jan; 8(1):17-33. PMID: 14589588.
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  136. Andrykowski MA, Schmitt FA, Gregg ME, Brady MJ, Lamb DG, Henslee-Downey PJ. Neuropsychologic impairment in adult bone marrow transplant candidates. Cancer. 1992 Nov 1; 70(9):2288-97. PMID: 1394058.
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  137. DeKosky ST, Harbaugh RE, Schmitt FA, Bakay RA, Chui HC, Knopman DS, Reeder TM, Shetter AG, Senter HJ, Markesbery WR. Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group. Ann Neurol. 1992 Nov; 32(5):625-32. PMID: 1360195.
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  138. Phillips BA, Berry DT, Schmitt FA, Magan LK, Gerhardstein DC, Cook YR. Sleep-disordered breathing in the healthy elderly. Clinically significant? Chest. 1992 Feb; 101(2):345-9. PMID: 1735252.
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  139. Dickson LR, Hays LR, Kaplan C, Scherl E, Abbott S, Schmitt F. Psychological profile of somatizing patients attending the integrative clinic. Int J Psychiatry Med. 1992; 22(2):141-53. PMID: 1517021.
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  140. Berry DT, Phillips BA, Cook YR, Schmitt FA, Honeycutt NA, Arita AA, Allen RS. Geriatric sleep apnea syndrome: a preliminary description. J Gerontol. 1990 Sep; 45(5):M169-74. PMID: 2394913.
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  141. Phillips BA, Schmitt FA, Berry DT, Lamb DG, Amin M, Cook YR. Treatment of obstructive sleep apnea. A preliminary report comparing nasal CPAP to nasal oxygen in patients with mild OSA. Chest. 1990 Aug; 98(2):325-30. PMID: 2198135.
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  142. DeKosky ST, Shih WJ, Schmitt FA, Coupal J, Kirkpatrick C. Assessing utility of single photon emission computed tomography (SPECT) scan in Alzheimer disease: correlation with cognitive severity. Alzheimer Dis Assoc Disord. 1990; 4(1):14-23. PMID: 2317335.
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  143. Phillips B, Cook Y, Schmitt F, Berry D. Sleep apnea: prevalence of risk factors in a general population. South Med J. 1989 Sep; 82(9):1090-2. PMID: 2672353.
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  144. Schmitt FA, Ranseen JD, DeKosky ST. Cognitive mental status examinations. Clin Geriatr Med. 1989 Aug; 5(3):545-64. PMID: 2680033.
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  145. Berry DT, Phillips BA, Cook YR, Schmitt FA, Honeycutt NA, Edwards CL, Lamb DG, Magan LK, Allen RS. Sleep-disordered breathing in healthy aged persons: one-year follow-up of daytime sequelae. Sleep. 1989 Jun; 12(3):211-5. PMID: 2740692.
    View in: PubMed
  146. Johnson MM, Schmitt FA, Pietrukowicz M. The memory advantages of the generation effect: age and process differences. J Gerontol. 1989 May; 44(3):P91-4. PMID: 2715591.
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  147. Phillips B, Berry D, Schmitt F, Patel R, Cook Y. Sleep quality and pulmonary function in the healthy elderly. Chest. 1989 Jan; 95(1):60-4. PMID: 2909357.
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  148. Macciocchi SN, Ranseen JD, Schmitt FA. The relationship between neuropsychological impairment in alcoholics and treatment outcome at one year. Arch Clin Neuropsychol. 1989; 4(4):365-70. PMID: 14591132.
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  149. Schmitt FA, Bigley JW, McKinnis R, Logue PE, Evans RW, Drucker JL. Neuropsychological outcome of zidovudine (AZT) treatment of patients with AIDS and AIDS-related complex. N Engl J Med. 1988 Dec 15; 319(24):1573-8. PMID: 3059187.
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  150. Farber JF, Schmitt FA, Logue PE. Predicting intellectual level from the Mini-Mental State Examination. J Am Geriatr Soc. 1988 Jun; 36(6):509-10. PMID: 3372930.
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  151. Murphy MD, Schmitt FA, Caruso MJ, Sanders RE. Metamemory in older adults: the role of monitoring in serial recall. Psychol Aging. 1987 Dec; 2(4):331-9. PMID: 3268225.
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  152. Berry DT, Phillips BA, Cook YR, Schmitt FA, Gilmore RL, Patel R, Keener TM, Tyre E. Sleep-disordered breathing in healthy aged persons: possible daytime sequelae. J Gerontol. 1987 Nov; 42(6):620-6. PMID: 3680881.
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  153. Logue PE, Schmitt FA, Rogers HE, Strong GB. Cognitive and emotional changes during a simulated 686-m deep dive. Undersea Biomed Res. 1986 Jun; 13(2):225-35. PMID: 3727184.
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  154. Mitchell DB, Hunt RR, Schmitt FA. The generation effect and reality monitoring: evidence from dementia and normal aging. J Gerontol. 1986 Jan; 41(1):79-84. PMID: 3941260.
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  155. Stoudemire A, Miller J, Schmitt F, Logue P, Shelton D, Latson G, Bennett P. Development of an organic affective syndrome during a hyperbaric diving experiment. Am J Psychiatry. 1984 Oct; 141(10):1251-4. PMID: 6435458.
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  156. Schmitt FA, Murphy MD, Sanders RE. Training older adult free recall rehearsal strategies. J Gerontol. 1981 May; 36(3):329-37. PMID: 7229280.
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  157. Murphy MD, Sanders RE, Gabriesheski AS, Schmitt FA. Metamemory in the aged. J Gerontol. 1981 Mar; 36(2):185-93. PMID: 7193705.
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  158. Sanders RE, Murphy MD, Schmitt FA, Walsh KK. Age differences in free recall rehearsal strategies. J Gerontol. 1980 Jul; 35(4):550-8. PMID: 7400548.
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