Charles T. Lutz, MD, PhD

Vice Chair for Research
Director of Molecular Pathology

Practice areas

Practice areas

Clinical interests

  • Histocompatibility and Tissue Typing
  • Laboratory Medicine
  • Molecular Genetic Pathology
  • Protein Electrophoresis

Charles T. Lutz, MD, PhD

Vice Chair for Research
Director of Molecular Pathology

Biography

My name is Charles T. Lutz; I received my medical degree from the University of Chicago, Division of the Biological Sciences, Pritzker School of Medicine. I am board certified by the American Board of Pathology in Clinical Pathology and in Molecular Genetic Pathology.

Faculty rank

Professor of Pathology and Laboratory Medicine

Education

Degree
University of Chicago, Division of the Biological Sciences, Pritzker School of Medicine

Residency
Barnes Jewish Hospital, St. Louis

Certifications or Special training
American Board of Pathology
American Board of Pathology, Clinical Pathology
American Board of Pathology, Molecular Genetic Pathology

Pathology and Laboratory Medicine

UK Albert B. Chandler Hospital - Pavilion H
Room MS-117
800 Rose St.
Lexington KY 40536-0293

Call 859-323-5425
Fax 859-323-2094

Amenities
ATM, Dining, Gift shop, Information desk, Post office

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  1. Al-Attar A, Presnell SR, Peterson CA, Thomas DT, Lutz CT. Data correlations between gender, cytomegalovirus infection and T cells, NK cells, and soluble immune mediators in elderly humans. Data Brief. 2016 Sep;8:536-44.
    View in: PubMed
  2. Al-Attar A, Presnell SR, Peterson CA, Thomas DT, Lutz CT. The effect of sex on immune cells in healthy aging: Elderly women have more robust natural killer lymphocytes than do elderly men. Mech Ageing Dev. 2016 Jun;156:25-33.
    View in: PubMed
  3. Hart JD, Lutz CT, Jennings CD, May JR, Nelson K, Jacobs S, Hoopes CW. Falsely incompatible B-cell flow cytometry crossmatch after pronase treatment: a case report. Transplant Proc. 2015 Apr;47(3):831-3.
    View in: PubMed
  4. Presnell SR, Al-Attar A, Cichocki F, Miller JS, Lutz CT. Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs. Genes Immun. 16(1):89-98.
    View in: PubMed
  5. Lutz CT, Al-Attar A, May JR, Jennings CD. Alloantibody to a Bw4 epitope in a Bw4+B*27: 05 patient. Transplantation. 2014 Oct 27;98(8):853-6.
    View in: PubMed
  6. Presnell SR, Chan HW, Zhang L, Lutz CT. IL-2/IL-15 activate the human clonally restricted KIR3DL1 reverse promoter. Genes Immun. 2013 Mar; 14(2):107-14. PMID: 23328843.
    View in: PubMed
  7. Lutz CT, Quinn LS. Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism. Aging (Albany NY). 2012 Aug; 4(8):535-46. PMID: 22935594.
    View in: PubMed
  8. Segerstrom SC, Al-Attar A, Lutz CT. Psychosocial resources, aging, and natural killer cell terminal maturity. Psychol Aging. 2012 Dec; 27(4):892-902. PMID: 22708535.
    View in: PubMed
  9. Presnell SR, Zhang L, Chlebowy CN, Al-Attar A, Lutz CT. Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/15-treated conditions. J Immunol. 2012 May 1; 188(9):4394-404. PMID: 22467658.
    View in: PubMed
  10. Cichocki F, Felices M, McCullar V, Presnell SR, Al-Attar A, Lutz CT, Miller JS. Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol. 2011 Dec 15; 187(12):6171-5. PMID: 22084432.
    View in: PubMed
  11. Lutz CT, Karapetyan A, Al-Attar A, Shelton BJ, Holt KJ, Tucker JH, Presnell SR. Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults. J Immunol. 2011 Apr 15; 186(8):4590-8. PMID: 21402893.
    View in: PubMed
  12. Butler JE, Moore MB, Presnell SR, Chan HW, Chalupny NJ, Lutz CT. Proteasome regulation of ULBP1 transcription. J Immunol. 2009 May 15; 182(10):6600-9. PMID: 19414815.
    View in: PubMed
  13. Binyamin L, Alpaugh RK, Hughes TL, Lutz CT, Campbell KS, Weiner LM. Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy. J Immunol. 2008 May 1; 180(9):6392-401. PMID: 18424763.
    View in: PubMed
  14. McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS. Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Exp Hematol. 2008 May; 36(5):598-608. PMID: 18295962.
    View in: PubMed
  15. Presnell SR, Zhang L, Ramilo CA, Chan HW, Lutz CT. Functional redundancy of transcription factor-binding sites in the killer cell Ig-like receptor (KIR) gene promoter. Int Immunol. 2006 Aug; 18(8):1221-32. PMID: 16818466.
    View in: PubMed
  16. Chan HW, Miller JS, Moore MB, Lutz CT. Epigenetic control of highly homologous killer Ig-like receptor gene alleles. J Immunol. 2005 Nov 1; 175(9):5966-74. PMID: 16237090.
    View in: PubMed
  17. Rayhill SC, Kirby PA, Voigt MD, La Brecque DR, Lutz CT, Katz DA, Mitros FA, Kalil RS, Miller RA, Stolpen AH, Heisey D, Wu YM, Schmidt WN. Positive serum cryoglobulin is associated with worse outcome after liver transplantation for chronic hepatitis C. Transplantation. 2005 Aug 27; 80(4):448-56. PMID: 16123717.
    View in: PubMed
  18. Lutgendorf SK, Moore MB, Bradley S, Shelton BJ, Lutz CT. Distress and expression of natural killer receptors on lymphocytes. Brain Behav Immun. 2005 May; 19(3):185-94. PMID: 15797305.
    View in: PubMed
  19. Lutz CT, Moore MB, Bradley S, Shelton BJ, Lutgendorf SK. Reciprocal age related change in natural killer cell receptors for MHC class I. Mech Ageing Dev. 2005 Jun-Jul; 126(6-7):722-31. PMID: 15888327.
    View in: PubMed
  20. Moore MB, Kurago ZB, Fullenkamp CA, Lutz CT. Squamous cell carcinoma cells differentially stimulate NK cell effector functions: the role of IL-18. Cancer Immunol Immunother. 2003 Feb; 52(2):107-15. PMID: 12594574.
    View in: PubMed
  21. Chan HW, Kurago ZB, Stewart CA, Wilson MJ, Martin MP, Mace BE, Carrington M, Trowsdale J, Lutz CT. DNA methylation maintains allele-specific KIR gene expression in human natural killer cells. J Exp Med. 2003 Jan 20; 197(2):245-55. PMID: 12538663.
    View in: PubMed
  22. Reber AJ, Turnquist HR, Thomas HJ, Lutz CT, Solheim JC. Expression of invariant chain can cause an allele-dependent increase in the surface expression of MHC class I molecules. Immunogenetics. 2002 May; 54(2):74-81. PMID: 12037599.
    View in: PubMed
  23. Shi Y, Lutz CT. Interferon--gamma control of EBV-transformed B cells: a role for CD8+ T cells that poorly kill EBV-infected cells. Viral Immunol. 2002; 15(1):213-25. PMID: 11952143.
    View in: PubMed
  24. Turnquist HR, Thomas HJ, Prilliman KR, Lutz CT, Hildebrand WH, Solheim JC. HLA-B polymorphism affects interactions with multiple endoplasmic reticulum proteins. Eur J Immunol. 2000 Oct; 30(10):3021-8. PMID: 11069086.
    View in: PubMed
  25. Lutz CT, Kurago ZB. Human leukocyte antigen class I expression on squamous cell carcinoma cells regulates natural killer cell activity. Cancer Res. 1999 Nov 15; 59(22):5793-9. PMID: 10582701.
    View in: PubMed
  26. Chiu BC, Cerhan JR, Gapstur SM, Sellers TA, Zheng W, Lutz CT, Wallace RB, Potter JD. Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women. Br J Cancer. 1999 Jul; 80(9):1476-82. PMID: 10424754.
    View in: PubMed
  27. Lutz CT, Browne G, Petzold CR. Methylcholanthrene causes increased thymocyte apoptosis. Toxicology. 1998 Jul 3; 128(2):151-67. PMID: 9710156.
    View in: PubMed
  28. Lutz CT, Foster PA, Noll WW, Voelkerding KV, Press RD, McGlennen RC, Kirschbaum NE. Multicenter evaluation of PCR methods for the detection of factor V Leiden (R506Q) genotypes. Clin Chem. 1998 Jun; 44(6 Pt 1):1356-8. PMID: 9625070.
    View in: PubMed
  29. Shi Y, Smith KD, Lutz CT. TAP-independent MHC class I peptide antigen presentation to alloreactive CTL is enhanced by target cell incubation at subphysiologic temperatures. J Immunol. 1998 May 1; 160(9):4305-12. PMID: 9574533.
    View in: PubMed
  30. Kurago ZB, Lutz CT, Smith KD, Colonna M. NK cell natural cytotoxicity and IFN-gamma production are not always coordinately regulated: engagement of DX9 KIR+ NK cells by HLA-B7 variants and target cells. J Immunol. 1998 Feb 15; 160(4):1573-80. PMID: 9469412.
    View in: PubMed
  31. Shi Y, Smith KD, Kurilla MG, Lutz CT. Cytotoxic CD8+ T cells recognize EBV antigen but poorly kill autologous EBV-infected B lymphoblasts: immunodominance is elicited by a peptide epitope that is presented at low levels in vitro. J Immunol. 1997 Aug 15; 159(4):1844-52. PMID: 9257848.
    View in: PubMed
  32. Smith KD, Huczko E, Engelhard VH, Li YY, Lutz CT. Alloreactive cytotoxic T lymphocytes focus on specific major histocompatibility complex-bound peptides. Transplantation. 1997 Jul 27; 64(2):351-9. PMID: 9256200.
    View in: PubMed
  33. Smith KD, Lutz CT. Alloreactive T cell recognition of MHC class I molecules: the T cell receptor interacts with limited regions of the MHC class I long alpha helices. J Immunol. 1997 Mar 15; 158(6):2805-12. PMID: 9058816.
    View in: PubMed
  34. Cerhan JR, Wallace RB, Folsom AR, Potter JD, Sellers TA, Zheng W, Lutz CT. Medical history risk factors for non-Hodgkin's lymphoma in older women. J Natl Cancer Inst. 1997 Feb 19; 89(4):314-8. PMID: 9048836.
    View in: PubMed
  35. Smith KD, Kurago ZB, Lutz CT. Conformational changes in MHC class I molecules. Antibody, T-cell receptor, and NK cell recognition in an HLA-B7 model system. Immunol Res. 1997; 16(3):243-59. PMID: 9379075.
    View in: PubMed
  36. Voelkerding KV, Huber S, Strobl F, Wu LA, Sabatini LM, Anderson M, Lutz CT. Resistance to Activated Protein C: Comparison of Three Different PCR Methods for Detection FV R506Q. Mol Diagn. 1996 Dec; 1(4):297-304. PMID: 10462576.
    View in: PubMed
  37. Vigna JL, Smith KD, Lutz CT. Invariant chain association with MHC class I: preference for HLA class I/beta 2-microglobulin heterodimers, specificity, and influence of the MHC peptide-binding groove. J Immunol. 1996 Nov 15; 157(10):4503-10. PMID: 8906828.
    View in: PubMed
  38. Li YY, Smith KD, Shi Y, Lutz CT. Alloreactive anti-HLA-B7 cytolytic T cell clones use restricted T cell receptor genes. Transplantation. 1996 Oct 15; 62(7):954-61. PMID: 8878390.
    View in: PubMed
  39. Smith KD, Mace BE, Valenzuela A, Vigna JL, McCutcheon JA, Barbosa JA, Huczko E, Engelhard VH, Lutz CT. Probing HLA-B7 conformational shifts induced by peptide-binding groove mutations and bound peptide with anti-HLA monoclonal antibodies. J Immunol. 1996 Sep 15; 157(6):2470-8. PMID: 8805647.
    View in: PubMed
  40. Smith KD, Lutz CT. Peptide-dependent expression of HLA-B7 on antigen processing-deficient T2 cells. J Immunol. 1996 May 15; 156(10):3755-64. PMID: 8621911.
    View in: PubMed
  41. Zarling AL, Smith KD, Lutz CT, Lee DR. Correction of the HLA-Cw3 genomic sequence tentatively identifies it as HLA-Cw*0304. Immunogenetics. 1996; 44(1):82-3. PMID: 8613148.
    View in: PubMed
  42. Smith KD, Epperson DF, Lutz CT. Alloreactive cytotoxic T-lymphocyte-defined HLA-B7 subtypes differ in peptide antigen presentation. Immunogenetics. 1996; 43(1-2):27-37. PMID: 8537119.
    View in: PubMed
  43. McCutcheon JA, Gumperz J, Smith KD, Lutz CT, Parham P. Low HLA-C expression at cell surfaces correlates with increased turnover of heavy chain mRNA. J Exp Med. 1995 Jun 1; 181(6):2085-95. PMID: 7760000.
    View in: PubMed
  44. Kurago ZB, Smith KD, Lutz CT. NK cell recognition of MHC class I. NK cells are sensitive to peptide-binding groove and surface alpha-helical mutations that affect T cells. J Immunol. 1995 Mar 15; 154(6):2631-41. PMID: 7876538.
    View in: PubMed
  45. Lutz CT, Smith KD, Greazel NS, Mace BE, Jensen DA, McCutcheon JA, Goeken NE. Bw4-reactive and Bw6-reactive antibodies recognize multiple distinct HLA structures that partially overlap in the alpha-1 helix. J Immunol. 1994 Nov 1; 153(9):4099-110. PMID: 7523516.
    View in: PubMed
  46. Hardarson S, Anderson ME, Lutz CT. Presence of Epstein-Barr virus in many types of benign and malignant lymphoid lesions. Detection by polymerase chain reaction and in situ hybridization. Diagn Mol Pathol. 1994 Mar; 3(1):22-31. PMID: 8162252.
    View in: PubMed
  47. De Vito LD, Mason BP, Jankowska-Gan E, Hogan KT, Guo JW, Lutz CT, Sollinger HW, Burlingham WJ. Epitope fine specificity of human anti-HLA-A2 antibodies. Identification of four epitopes including a haptenlike epitope on HLA-A2 at lysine 127. Hum Immunol. 1993 Jul; 37(3):165-77. PMID: 7503972.
    View in: PubMed
  48. Smith KD, Valenzuela A, Vigna JL, Aalbers K, Lutz CT. Unwanted mutations in PCR mutagenesis: avoiding the predictable. PCR Methods Appl. 1993 Feb; 2(3):253-7. PMID: 8443578.
    View in: PubMed
  49. McCutcheon JA, Smith KD, Valenzuela A, Aalbers K, Lutz CT. HLA-B*0702 antibody epitopes are affected indirectly by distant antigen residues. Hum Immunol. 1993 Feb; 36(2):69-75. PMID: 7681814.
    View in: PubMed
  50. DeVito LD, Hogan KT, Mason BP, Guo JW, Lutz CT, Sollinger HW, Burlingham WJ. Epitope fine specificity of human anti-HLA-A2 antibodies. Transplant Proc. 1993 Feb; 25(1 Pt 1):189-90. PMID: 7679810.
    View in: PubMed
  51. McCutcheon JA, Lutz CT. Mutagenesis around residue 176 on HLA-B*0702 characterizes multiple distinct epitopes for anti-HLA antibodies. Hum Immunol. 1992 Oct; 35(2):125-31. PMID: 1283748.
    View in: PubMed
  52. Gulley ML, Raphael M, Lutz CT, Ross DW, Raab-Traub N. Epstein-Barr virus integration in human lymphomas and lymphoid cell lines. Cancer. 1992 Jul 1; 70(1):185-91. PMID: 1318776.
    View in: PubMed
  53. Cai J, Humphries C, Lutz C, Tucker PW. Analysis of VH251 gene mutation in chronic lymphocytic leukemia (CLL) and normal B-cell subsets. Ann N Y Acad Sci. 1992 May 4; 651:384-92. PMID: 1599132.
    View in: PubMed
  54. Laszewski MJ, Belding PJ, Feddersen RM, Lutz CT, Goeken JA, Kemp JD, Dick FR. Clonal immunoglobulin gene rearrangement in the infarcted lymph node syndrome. Am J Clin Pathol. 1991 Jul; 96(1):116-20. PMID: 2069129.
    View in: PubMed
  55. Lutz CT, Cornell SH, Goeken JA. Establishment of a reference interval for beta 2-microglobulin in cerebrospinal fluid with use of two commercial assays. Clin Chem. 1991 Jan; 37(1):104-7. PMID: 1988188.
    View in: PubMed
  56. Lutz CT, Jensen DA, Schiffenbauer J, Didier DK, Schwartz BD, Davis CS. Multiple mechanisms produce diversity of HLA-C alleles. Hum Immunol. 1990 May; 28(1):27-31. PMID: 2341305.
    View in: PubMed
  57. Lutz CT, Galles ME, Kemp JD, Goeken JA, Dick FR. Kappa immunoglobulin light chain gene rearrangement in a T-lineage chronic lymphocytic leukemia. Am J Clin Pathol. 1990 May; 93(5):702-5. PMID: 2109525.
    View in: PubMed
  58. Kamat D, Laszewski MJ, Kemp JD, Goeken JA, Lutz CT, Platz CE, Dick FR. The diagnostic utility of immunophenotyping and immunogenotyping in the pathologic evaluation of lymphoid proliferations. Mod Pathol. 1990 Mar; 3(2):105-12. PMID: 2183210.
    View in: PubMed
  59. Lutz CT, Davie JM. Genetics and primary structure of V kappa gene segments encoding antibody to streptococcal group A carbohydrate. Comparison of V kappa gene structure with idiotope expression. J Immunol. 1988 Jan 15; 140(2):641-5. PMID: 3121751.
    View in: PubMed
  60. Lutz CT, Hollifield WC, Seed B, Davie JM, Huang HV. Syrinx 2A: an improved lambda phage vector designed for screening DNA libraries by recombination in vivo. Proc Natl Acad Sci U S A. 1987 Jul; 84(13):4379-83. PMID: 2955406.
    View in: PubMed
  61. Lutz CT, Bartholow TL, Greenspan NS, Fulton RJ, Monafo WJ, Perlmutter RM, Huang HV, Davie JM. Molecular dissection of the murine antibody response to streptococcal group A carbohydrate. J Exp Med. 1987 Feb 1; 165(2):531-45. PMID: 3102673.
    View in: PubMed
  62. Davie JM, Seiden MV, Greenspan NS, Lutz CT, Bartholow TL, Clevinger BL. Structural correlates of idiotopes. Annu Rev Immunol. 1986; 4:147-65. PMID: 2423099.
    View in: PubMed
  63. Lutz CT, Bell CE, Wedner HJ, Krogstad DJ. Allergy testing of multiple patients should no longer be performed with a common syringe. N Engl J Med. 1984 May 17; 310(20):1335-7. PMID: 6371529.
    View in: PubMed
  64. Lutz CT, Glasebrook AL, Fitch FW. Enumeration of alloreactive helper T lymphocytes which cooperate with cytolytic T lymphocytes. Eur J Immunol. 1981 Sep; 11(9):726-34. PMID: 6975213.
    View in: PubMed
  65. Lutz CT. The generation of cytolytic activity in mixed leukocyte cultures: cortisone-resistant thymocytes are deficient in helper T lymphocytes. J Immunol. 1981 Sep; 127(3):1156-63. PMID: 6455469.
    View in: PubMed
  66. Lutz CT, Glasebrook AL, Fitch FW. Alloreactive cloned T cell lines. IV. Interaction of alloantigen and T cell growth factors (TCGF) to stimulate cloned cytolytic T lymphocytes. J Immunol. 1981 Jul; 127(1):391-2. PMID: 6453898.
    View in: PubMed
  67. Lutz CT, Glasebrook AL, Fitch FW. Alloreactive cloned T cell lines. III. Accessory cell requirements for the growth of cloned cytolytic T lymphocytes. J Immunol. 1981 Apr; 126(4):1404-8. PMID: 6970775.
    View in: PubMed
  68. Glasebrook AL, Sarmiento M, Loken MR, Dialynas DP, Quintans J, Eisenberg L, Lutz CT, Wilde D, Fitch FW. Murine T lymphocyte clones with distinct immunological functions. Immunol Rev. 1981; 54:225-66. PMID: 6166535.
    View in: PubMed
  69. Lutz CT, Fitch FW. Accessory cell requirements for the generation of cytolytic T lymphocytes. J Immunol. 1979 Jun; 122(6):2598-604. PMID: 109533.
    View in: PubMed