Philip A. Kern, MD

Director, Center for Clinical and Translational Sciences

Clinical interests

  • Atherosclerosis Prevention
  • Diabetes
  • Endocrinology
  • Lipid Disorders
  • Nutrition
  • Obesity

Philip A. Kern, MD

Director, Center for Clinical and Translational Sciences

Biography

My name is Philip Kern; I received my medical degree from New York Medical College, Valhalla. I completed a fellowship at the University of Colorado Health Sciences Center, Denver.

I am board certified by the American Board of Internal Medicine in Endocrinology and Metabolism. I am engaged in research on obesity and diabetes and am director of the Center for Clinical and Translational Sciences.

Faculty rank

Professor of Medicine

Education

Degree
New York Medical College, Valhalla

Residency
Montefiore Medical Center of Albert Einstein, College of Medicine, Bronx, N.Y.

Fellowship
University of Colorado Health Sciences Center, Denver

Certifications or Special training
American Board of Internal Medicine
American Board of Internal Medicine, Endocrinology and Metabolism

Endocrinology

Medicine Specialties

Kentucky Clinic
Second Floor, Wing C
740 S. Limestone
Lexington KY 40536-0284

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Fax 859-257-2634

Amenities
Dining, Internet/Wi-Fi, Information desk, Pharmacy services, Wheelchairs

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  1. Helsley RN, Sui Y, Park SH, Liu Z, Lee RG, Zhu B, Kern PA, Zhou C. Targeting IκB kinase β in Adipocyte Lineage Cells for Treatment of Obesity and Metabolic Dysfunctions. Stem Cells. 2016 Jul;34(7):1883-95.
    View in: PubMed
  2. Park SH, Liu Z, Sui Y, Helsley RN, Zhu B, Powell DK, Kern PA, Zhou C. IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in Obesity. Diabetes. 2016 Jun;65(6):1616-29.
    View in: PubMed
  3. Lawler HM, Underkofler CM, Kern PA, Erickson C, Bredbeck B, Rasouli N. Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant Subjects. J Clin Endocrinol Metab. 2016 Apr;101(4):1422-8.
    View in: PubMed
  4. Kirby TJ, Walton RG, Finlin B, Zhu B, Unal R, Rasouli N, Peterson CA, Kern PA. Integrative mRNA-microRNA analyses reveal novel interactions related to insulin sensitivity in human adipose tissue. Physiol Genomics. 2016 Feb;48(2):145-53.
    View in: PubMed
  5. Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP. Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep. 2015 Dec;38(12):1849-60.
    View in: PubMed
  6. Finlin BS, Zhu B, Starnes CP, McGehee RE, Peterson CA, Kern PA. Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids. J Nutr Biochem. 2013 Sep; 24(9):1571-9. PMID: 23528972.
    View in: PubMed
  7. Ma L, Murea M, Snipes JA, Marinelarena A, Krüger J, Hicks PJ, Langberg KA, Bostrom MA, Cooke JN, Suzuki D, Babazono T, Uzu T, Tang SC, Mondal AK, Sharma NK, Kobes S, Antinozzi PA, Davis M, Das SK, Rasouli N, Kern PA, Shores NJ, Rudel LL, Blüher M, Stumvoll M, Bowden DW, Maeda S, Parks JS, Kovacs P, Hanson RL, Baier LJ, Elbein SC, Freedman BI. An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects. PLoS One. 2013; 8(2):e56193. PMID: 23460794.
    View in: PubMed
  8. Spencer M, Finlin BS, Unal R, Zhu B, Morris AJ, Shipp LR, Lee J, Walton RG, Adu A, Erfani R, Campbell M, McGehee RE, Peterson CA, Kern PA. Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance. Diabetes. 2013 May; 62(5):1709-17. PMID: 23328126.
    View in: PubMed
  9. Elbein SC, Gamazon ER, Das SK, Rasouli N, Kern PA, Cox NJ. Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture? Am J Hum Genet. 2012 Sep 7; 91(3):466-77. PMID: 22958899.
    View in: PubMed
  10. Rasouli N, Kern PA, Elbein SC, Sharma NK, Das SK. Improved insulin sensitivity after treatment with PPAR? and PPARa ligands is mediated by genetically modulated transcripts. Pharmacogenet Genomics. 2012 Jul; 22(7):484-97. PMID: 22437669.
    View in: PubMed
  11. Finlin BS, Bodles-Brakhop AM, Yao-Borengasser A, Zhu B, Starnes CP, McGehee RE, Peterson CA, Kern PA, Rasouli N. Regulation of small ubiquitin-like modifier-1, nuclear receptor coreceptor, histone deacetylase 3, and peroxisome proliferator-activated receptor-? in human adipose tissue. Metab Syndr Relat Disord. 2012 Aug; 10(4):312-7. PMID: 22651256.
    View in: PubMed
  12. Ranganathan G, Unal R, Pokrovskaya ID, Tripathi P, Rotter JI, Goodarzi MO, Kern PA. The lipoprotein lipase (LPL) S447X gain of function variant involves increased mRNA translation. Atherosclerosis. 2012 Mar; 221(1):143-7. PMID: 22244040.
    View in: PubMed
  13. Spencer M, Unal R, Zhu B, Rasouli N, McGehee RE, Peterson CA, Kern PA. Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance. J Clin Endocrinol Metab. 2011 Dec; 96(12):E1990-8. PMID: 21994960.
    View in: PubMed
  14. Finlin BS, Varma V, Nolen GT, Dubé J, Starnes CP, Rasouli N, Kern PA, Peterson CA. DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages. J Nutr Biochem. 2012 Aug; 23(8):885-91. PMID: 21852085.
    View in: PubMed
  15. Zhang H, Xie C, Spencer HJ, Zuo C, Higuchi M, Ranganathan G, Kern PA, Chou MW, Huang Q, Szczesny B, Mitra S, Watson AJ, Margison GP, Fan CY. Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria. Am J Pathol. 2011 Apr; 178(4):1715-27. PMID: 21435453.
    View in: PubMed
  16. Elbein SC, Kern PA, Rasouli N, Yao-Borengasser A, Sharma NK, Das SK. Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI. Diabetes. 2011 Mar; 60(3):1019-29. PMID: 21266331.
    View in: PubMed
  17. Yao-Borengasser A, Varma V, Coker RH, Ranganathan G, Phanavanh B, Rasouli N, Kern PA. Adipose triglyceride lipase expression in human adipose tissue and muscle. Role in insulin resistance and response to training and pioglitazone. Metabolism. 2011 Jul; 60(7):1012-20. PMID: 21129760.
    View in: PubMed
  18. Spencer M, Yao-Borengasser A, Unal R, Rasouli N, Gurley CM, Zhu B, Peterson CA, Kern PA. Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation. Am J Physiol Endocrinol Metab. 2010 Dec; 299(6):E1016-27. PMID: 20841504.
    View in: PubMed
  19. Smith LM, Yao-Borengasser A, Starks T, Tripputi M, Kern PA, Rasouli N. Insulin resistance in African-American and Caucasian women: differences in lipotoxicity, adipokines, and gene expression in adipose tissue and muscle. J Clin Endocrinol Metab. 2010 Sep; 95(9):4441-8. PMID: 20591983.
    View in: PubMed
  20. Unal R, Yao-Borengasser A, Varma V, Rasouli N, Labbate C, Kern PA, Ranganathan G. Matrix metalloproteinase-9 is increased in obese subjects and decreases in response to pioglitazone. J Clin Endocrinol Metab. 2010 Jun; 95(6):2993-3001. PMID: 20392866.
    View in: PubMed
  21. Coker RH, Williams RH, Yeo SE, Kortebein PM, Bodenner DL, Kern PA, Evans WJ. The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity. J Clin Endocrinol Metab. 2009 Nov; 94(11):4258-66. PMID: 19808853.
    View in: PubMed
  22. Rasouli N, Yao-Borengasser A, Varma V, Spencer HJ, McGehee RE, Peterson CA, Mehta JL, Kern PA. Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans. Arterioscler Thromb Vasc Biol. 2009 Sep; 29(9):1328-35. PMID: 19667111.
    View in: PubMed
  23. Varma V, Yao-Borengasser A, Rasouli N, Nolen GT, Phanavanh B, Starks T, Gurley C, Simpson P, McGehee RE, Kern PA, Peterson CA. Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. Am J Physiol Endocrinol Metab. 2009 Jun; 296(6):E1300-10. PMID: 19336660.
    View in: PubMed
  24. Coker RH, Williams RH, Yeo SE, Kortebein PM, Bodenner DL, Kern PA, Evans WJ. Visceral fat and adiponectin: associations with insulin resistance are tissue-specific in women. Metab Syndr Relat Disord. 2009 Feb; 7(1):61-7. PMID: 19032037.
    View in: PubMed
  25. Banga A, Unal R, Tripathi P, Pokrovskaya I, Owens RJ, Kern PA, Ranganathan G. Adiponectin translation is increased by the PPARgamma agonists pioglitazone and omega-3 fatty acids. Am J Physiol Endocrinol Metab. 2009 Mar; 296(3):E480-9. PMID: 19088251.
    View in: PubMed
  26. Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab. 2008 Nov; 93(11 Suppl 1):S64-73. PMID: 18987272.
    View in: PubMed
  27. Sharma NK, Das SK, Mondal AK, Hackney OG, Chu WS, Kern PA, Rasouli N, Spencer HJ, Yao-Borengasser A, Elbein SC. Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab. 2008 Nov; 93(11):4532-41. PMID: 18728164.
    View in: PubMed
  28. Yao-Borengasser A, Rassouli N, Varma V, Bodles AM, Rasouli N, Unal R, Phanavanh B, Ranganathan G, McGehee RE, Kern PA. Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness. J Clin Endocrinol Metab. 2008 Nov; 93(11):4431-9. PMID: 18697866.
    View in: PubMed
  29. Unal R, Pokrovskaya I, Tripathi P, Monia BP, Kern PA, Ranganathan G. Translational regulation of lipoprotein lipase in adipocytes: depletion of cellular protein kinase Calpha activates binding of the C subunit of protein kinase A to the 3'-untranslated region of the lipoprotein lipase mRNA. Biochem J. 2008 Jul 15; 413(2):315-22. PMID: 18387001.
    View in: PubMed
  30. Das SK, Chu WS, Mondal AK, Sharma NK, Kern PA, Rasouli N, Elbein SC. Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. Am J Physiol Endocrinol Metab. 2008 Aug; 295(2):E393-400. PMID: 18544642.
    View in: PubMed
  31. Banga A, Bodles AM, Rasouli N, Ranganathan G, Kern PA, Owens RJ. Calcium is involved in formation of high molecular weight adiponectin. Metab Syndr Relat Disord. 2008 Jun; 6(2):103-11. PMID: 18510435.
    View in: PubMed
  32. Varma V, Yao-Borengasser A, Bodles AM, Rasouli N, Phanavanh B, Nolen GT, Kern EM, Nagarajan R, Spencer HJ, Lee MJ, Fried SK, McGehee RE, Peterson CA, Kern PA. Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance. Diabetes. 2008 Feb; 57(2):432-9. PMID: 18057090.
    View in: PubMed
  33. Yao-Borengasser A, Varma V, Bodles AM, Rasouli N, Phanavanh B, Lee MJ, Starks T, Kern LM, Spencer HJ, Rashidi AA, McGehee RE, Fried SK, Kern PA. Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone. J Clin Endocrinol Metab. 2007 Jul; 92(7):2590-7. PMID: 17595259.
    View in: PubMed
  34. Elbein SC, Chu WS, Das SK, Yao-Borengasser A, Hasstedt SJ, Wang H, Rasouli N, Kern PA. Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent. Diabetologia. 2007 Aug; 50(8):1621-30. PMID: 17579832.
    View in: PubMed
  35. Liu Z, Aronson J, Wahl EC, Liu L, Perrien DS, Kern PA, Fowlkes JL, Thrailkill KM, Bunn RC, Cockrell GE, Skinner RA, Lumpkin CK. A novel rat model for the study of deficits in bone formation in type-2 diabetes. Acta Orthop. 2007 Feb; 78(1):46-55. PMID: 17453392.
    View in: PubMed
  36. Rasouli N, Molavi B, Elbein SC, Kern PA. Ectopic fat accumulation and metabolic syndrome. Diabetes Obes Metab. 2007 Jan; 9(1):1-10. PMID: 17199713.
    View in: PubMed
  37. Wolins NE, Quaynor BK, Skinner JR, Tzekov A, Croce MA, Gropler MC, Varma V, Yao-Borengasser A, Rasouli N, Kern PA, Finck BN, Bickel PE. OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes. 2006 Dec; 55(12):3418-28. PMID: 17130488.
    View in: PubMed
  38. Varma V, Yao-Borengasser A, Rasouli N, Bodles AM, Phanavanh B, Lee MJ, Starks T, Kern LM, Spencer HJ, McGehee RE, Fried SK, Kern PA. Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation. J Clin Endocrinol Metab. 2007 Feb; 92(2):666-72. PMID: 17090638.
    View in: PubMed
  39. Yao-Borengasser A, Rasouli N, Varma V, Miles LM, Phanavanh B, Starks TN, Phan J, Spencer HJ, McGehee RE, Reue K, Kern PA. Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes. 2006 Oct; 55(10):2811-8. PMID: 17003347.
    View in: PubMed
  40. Rasouli N, Kern PA, Reece EA, Elbein SC. Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E359-65. PMID: 16968813.
    View in: PubMed
  41. Molavi B, Rasouli N, Kern PA. The prevention and treatment of metabolic syndrome and high-risk obesity. Curr Opin Cardiol. 2006 Sep; 21(5):479-85. PMID: 16900012.
    View in: PubMed
  42. Ranganathan G, Unal R, Pokrovskaya I, Yao-Borengasser A, Phanavanh B, Lecka-Czernik B, Rasouli N, Kern PA. The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. J Lipid Res. 2006 Nov; 47(11):2444-50. PMID: 16894240.
    View in: PubMed
  43. Bodles AM, Banga A, Rasouli N, Ono F, Kern PA, Owens RJ. Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes. Am J Physiol Endocrinol Metab. 2006 Nov; 291(5):E1100-5. PMID: 16803857.
    View in: PubMed
  44. Bodles AM, Varma V, Yao-Borengasser A, Phanavanh B, Peterson CA, McGehee RE, Rasouli N, Wabitsch M, Kern PA. Pioglitazone induces apoptosis of macrophages in human adipose tissue. J Lipid Res. 2006 Sep; 47(9):2080-8. PMID: 16799131.
    View in: PubMed
  45. Rasouli N, Yao-Borengasser A, Miles LM, Elbein SC, Kern PA. Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression. Am J Physiol Endocrinol Metab. 2006 Jan; 290(1):E42-E46. PMID: 16118250.
    View in: PubMed
  46. Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee RE, Kern PA. Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes. 2005 Aug; 54(8):2305-13. PMID: 16046295.
    View in: PubMed
  47. Ranganathan G, Pokrovskaya I, Ranganathan S, Kern PA. Role of A kinase anchor proteins in the tissue-specific regulation of lipoprotein lipase. Mol Endocrinol. 2005 Oct; 19(10):2527-34. PMID: 15961507.
    View in: PubMed
  48. Rasouli N, Raue U, Miles LM, Lu T, Di Gregorio GB, Elbein SC, Kern PA. Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue. Am J Physiol Endocrinol Metab. 2005 May; 288(5):E930-4. PMID: 15632102.
    View in: PubMed
  49. Kern PA, Said S, Jackson WG, Michalek JE. Insulin sensitivity following agent orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Clin Endocrinol Metab. 2004 Sep; 89(9):4665-72. PMID: 15356078.
    View in: PubMed
  50. Yue L, Rasouli N, Ranganathan G, Kern PA, Mazzone T. Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression. J Biol Chem. 2004 Nov 12; 279(46):47626-32. PMID: 15339912.
    View in: PubMed
  51. Di Gregorio GB, Hensley L, Lu T, Ranganathan G, Kern PA. Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E182-7. PMID: 15191885.
    View in: PubMed
  52. Di Gregorio GB, Westergren R, Enerback S, Lu T, Kern PA. Expression of FOXC2 in adipose and muscle and its association with whole body insulin sensitivity. Am J Physiol Endocrinol Metab. 2004 Oct; 287(4):E799-803. PMID: 15198934.
    View in: PubMed
  53. Kern PA, Di Gregorio G, Lu T, Rassouli N, Ranganathan G. Perilipin expression in human adipose tissue is elevated with obesity. J Clin Endocrinol Metab. 2004 Mar; 89(3):1352-8. PMID: 15001633.
    View in: PubMed
  54. Freundl G, Godehardt E, Kern PA, Frank-Herrmann P, Koubenec HJ, Gnoth Ch. Estimated maximum failure rates of cycle monitors using daily conception probabilities in the menstrual cycle. Hum Reprod. 2003 Dec; 18(12):2628-33. PMID: 14645183.
    View in: PubMed
  55. Wang H, Chu WS, Lu T, Hasstedt SJ, Kern PA, Elbein SC. Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Am J Physiol Endocrinol Metab. 2004 Jan; 286(1):E1-7. PMID: 12915397.
    View in: PubMed
  56. Kern PA, Di Gregorio GB, Lu T, Rassouli N, Ranganathan G. Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes. 2003 Jul; 52(7):1779-85. PMID: 12829646.
    View in: PubMed
  57. Hensley LL, Ranganathan G, Wagner EM, Wells BD, Daniel JC, Vu D, Semenkovich CF, Zechner R, Kern PA. Transgenic mice expressing lipoprotein lipase in adipose tissue. Absence of the proximal 3'-untranslated region causes translational upregulation. J Biol Chem. 2003 Aug 29; 278(35):32702-9. PMID: 12796491.
    View in: PubMed
  58. Fonseca VA, Fink LM, Kern PA. Insulin sensitivity and plasma homocysteine concentrations in non-diabetic obese and normal weight subjects. Atherosclerosis. 2003 Mar; 167(1):105-9. PMID: 12618274.
    View in: PubMed
  59. Ranganathan G, Phan D, Pokrovskaya ID, McEwen JE, Li C, Kern PA. The translational regulation of lipoprotein lipase by epinephrine involves an RNA binding complex including the catalytic subunit of protein kinase A. J Biol Chem. 2002 Nov 8; 277(45):43281-7. PMID: 12218046.
    View in: PubMed
  60. Ranganathan G, Song W, Dean N, Monia B, Barger SW, Kern PA. Regulation of lipoprotein lipase by protein kinase C alpha in 3T3-F442A adipocytes. J Biol Chem. 2002 Oct 11; 277(41):38669-75. PMID: 12149272.
    View in: PubMed
  61. Kern PA, Fishman RB, Song W, Brown AD, Fonseca V. The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver. Toxicology. 2002 Feb 28; 171(2-3):117-25. PMID: 11836018.
    View in: PubMed
  62. Ranganathan S, Kern PA. The HIV protease inhibitor saquinavir impairs lipid metabolism and glucose transport in cultured adipocytes. J Endocrinol. 2002 Jan; 172(1):155-62. PMID: 11786383.
    View in: PubMed
  63. Kern PA, Dicker-Brown A, Said ST, Kennedy R, Fonseca VA. The stimulation of tumor necrosis factor and inhibition of glucose transport and lipoprotein lipase in adipose cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Metabolism. 2002 Jan; 51(1):65-8. PMID: 11782874.
    View in: PubMed
  64. Dicker-Brown A, Fonseca VA, Fink LM, Kern PA. The effect of glucose and insulin on the activity of methylene tetrahydrofolate reductase and cystathionine-beta-synthase: studies in hepatocytes. Atherosclerosis. 2001 Oct; 158(2):297-301. PMID: 11583707.
    View in: PubMed
  65. Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2001 May; 280(5):E745-51. PMID: 11287357.
    View in: PubMed
  66. Ranganathan G, Li C, Kern PA. The translational regulation of lipoprotein lipase in diabetic rats involves the 3'-untranslated region of the lipoprotein lipase mRNA. J Biol Chem. 2000 Dec 29; 275(52):40986-91. PMID: 11024042.
    View in: PubMed
  67. Cranmer M, Louie S, Kennedy RH, Kern PA, Fonseca VA. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with hyperinsulinemia and insulin resistance. Toxicol Sci. 2000 Aug; 56(2):431-6. PMID: 10911003.
    View in: PubMed
  68. Fonseca V, Dicker-Brown A, Ranganathan S, Song W, Barnard RJ, Fink L, Kern PA. Effects of a high-fat-sucrose diet on enzymes in homocysteine metabolism in the rat. Metabolism. 2000 Jun; 49(6):736-41. PMID: 10877198.
    View in: PubMed
  69. Kern PA, Simsolo RB, Fournier M. Effect of weight loss on muscle fiber type, fiber size, capillarity, and succinate dehydrogenase activity in humans. J Clin Endocrinol Metab. 1999 Nov; 84(11):4185-90. PMID: 10566670.
    View in: PubMed
  70. Querfeld U, Hoffmann MM, Klaus G, Eifinger F, Ackerschott M, Michalk D, Kern PA. Antagonistic effects of vitamin D and parathyroid hormone on lipoprotein lipase in cultured adipocytes. J Am Soc Nephrol. 1999 Oct; 10(10):2158-64. PMID: 10505692.
    View in: PubMed
  71. Ranganathan G, Kaakaji R, Kern PA. Role of protein kinase C in the translational regulation of lipoprotein lipase in adipocytes. J Biol Chem. 1999 Mar 26; 274(13):9122-7. PMID: 10085163.
    View in: PubMed
  72. Ranganathan G, Kern PA. In vitro transcription and translation of lipoprotein lipase. Methods Mol Biol. 1999; 109:337-41. PMID: 9918034.
    View in: PubMed
  73. Ranganathan G, Kern PA. Techniques for the measurement of lipoprotein lipase messenger RNA. Methods Mol Biol. 1999; 109:329-35. PMID: 9918033.
    View in: PubMed
  74. Ciaraldi TP, Carter L, Mudaliar S, Kern PA, Henry RR. Effects of tumor necrosis factor-alpha on glucose metabolism in cultured human muscle cells from nondiabetic and type 2 diabetic subjects. Endocrinology. 1998 Dec; 139(12):4793-800. PMID: 9832415.
    View in: PubMed
  75. Ranganathan S, Kern PA. Thiazolidinediones inhibit lipoprotein lipase activity in adipocytes. J Biol Chem. 1998 Oct 2; 273(40):26117-22. PMID: 9748292.
    View in: PubMed
  76. Fonseca VA, Mudaliar S, Schmidt B, Fink LM, Kern PA, Henry RR. Plasma homocysteine concentrations are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects. Metabolism. 1998 Jun; 47(6):686-9. PMID: 9627367.
    View in: PubMed
  77. Ranganathan S, Ciaraldi TP, Henry RR, Mudaliar S, Kern PA. Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells. Endocrinology. 1998 May; 139(5):2509-13. PMID: 9564865.
    View in: PubMed
  78. Ranganathan S, Maffei M, Kern PA. Adipose tissue ob mRNA expression in humans: discordance with plasma leptin and relationship with adipose TNFalpha expression. J Lipid Res. 1998 Apr; 39(4):724-30. PMID: 9555938.
    View in: PubMed
  79. Kern PA. A prudent and practical approach to the treatment of obesity. J Ark Med Soc. 1997 Oct; 94(5):191-7. PMID: 9343968.
    View in: PubMed
  80. Kern PA. Potential role of TNFalpha and lipoprotein lipase as candidate genes for obesity. J Nutr. 1997 Sep; 127(9):1917S-1922S. PMID: 9278582.
    View in: PubMed
  81. Maheux P, Azhar S, Kern PA, Chen YD, Reuven GM. Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein lipase. Diabetologia. 1997 Jul; 40(7):850-8. PMID: 9243108.
    View in: PubMed
  82. Ranganathan G, Vu D, Kern PA. Translational regulation of lipoprotein lipase by epinephrine involves a trans-acting binding protein interacting with the 3' untranslated region. J Biol Chem. 1997 Jan 24; 272(4):2515-9. PMID: 8999967.
    View in: PubMed
  83. Choi SY, Pang L, Kern PA, Kayden HJ, Curtiss LK, Vanni-Reyes TM, Goldberg IJ. Dissociation of LPL and LDL: effects of lipoproteins and anti-apoB antibodies. J Lipid Res. 1997 Jan; 38(1):77-85. PMID: 9034202.
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  84. Kern PA, Ranganathan G, Yukht A, Ong JM, Davis RC. Translational regulation of lipoprotein lipase by thyroid hormone is via a cytoplasmic repressor that interacts with the 3' untranslated region. J Lipid Res. 1996 Nov; 37(11):2332-40. PMID: 8978485.
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  85. Vu D, Ong JM, Clemens TL, Kern PA. 1,25-Dihydroxyvitamin D induces lipoprotein lipase expression in 3T3-L1 cells in association with adipocyte differentiation. Endocrinology. 1996 May; 137(5):1540-4. PMID: 8612483.
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  86. Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest. 1996 Feb 15; 97(4):1111-6. PMID: 8613535.
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  87. Ong JM, Simsolo RB, Saghizadeh M, Goers JW, Kern PA. Effects of exercise training and feeding on lipoprotein lipase gene expression in adipose tissue, heart, and skeletal muscle of the rat. Metabolism. 1995 Dec; 44(12):1596-605. PMID: 8786730.
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  88. Yukht A, Davis RC, Ong JM, Ranganathan G, Kern PA. Regulation of lipoprotein lipase translation by epinephrine in 3T3-L1 cells. Importance of the 3' untranslated region. J Clin Invest. 1995 Nov; 96(5):2438-44. PMID: 7593632.
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  89. Simsolo RB, Ezzat S, Ong JM, Saghizadeh M, Kern PA. Effects of acromegaly treatment and growth hormone on adipose tissue lipoprotein lipase. J Clin Endocrinol Metab. 1995 Nov; 80(11):3233-8. PMID: 7593431.
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  90. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest. 1995 May; 95(5):2111-9. PMID: 7738178.
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  91. Ranganathan G, Ong JM, Yukht A, Saghizadeh M, Simsolo RB, Pauer A, Kern PA. Tissue-specific expression of human lipoprotein lipase. Effect of the 3'-untranslated region on translation. J Biol Chem. 1995 Mar 31; 270(13):7149-55. PMID: 7706252.
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  92. Ong JM, Simsolo RB, Saghizadeh M, Pauer A, Kern PA. Expression of lipoprotein lipase in rat muscle: regulation by feeding and hypothyroidism. J Lipid Res. 1994 Sep; 35(9):1542-51. PMID: 7806968.
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  93. Slavin BG, Ong JM, Kern PA. Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. J Lipid Res. 1994 Sep; 35(9):1535-41. PMID: 7806967.
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  94. Kern PA, Trozzolino L, Wolfe G, Purdy L. Combined use of behavior modification and very low-calorie diet in weight loss and weight maintenance. Am J Med Sci. 1994 May; 307(5):325-8. PMID: 8172224.
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  95. Venkatesan N, Davidson MB, Simsolo RB, Kern PA. Phenobarbital treatment enhances insulin-mediated glucose metabolism and improves lipid metabolism in the diabetic rat. Metabolism. 1994 Mar; 43(3):348-56. PMID: 8139483.
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  96. Simsolo RB, Ong JM, Kern PA. Effect of gemfibrozil on adipose tissue and muscle lipoprotein lipase. Metabolism. 1993 Nov; 42(11):1486-91. PMID: 8231846.
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  97. Simsolo RB, Ong JM, Kern PA. The regulation of adipose tissue and muscle lipoprotein lipase in runners by detraining. J Clin Invest. 1993 Nov; 92(5):2124-30. PMID: 8227328.
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  98. Simsolo RB, Ong JM, Kern PA. Characterization of lipoprotein lipase activity, secretion, and degradation at different sites of post-translational processing in primary cultures of rat adipocytes. J Lipid Res. 1992 Dec; 33(12):1777-84. PMID: 1479287.
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  99. Ong JM, Simsolo RB, Saffari B, Kern PA. The regulation of lipoprotein lipase gene expression by dexamethasone in isolated rat adipocytes. Endocrinology. 1992 Apr; 130(4):2310-6. PMID: 1547742.
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  100. Saffari B, Ong JM, Kern PA. Regulation of adipose tissue lipoprotein lipase gene expression by thyroid hormone in rats. J Lipid Res. 1992 Feb; 33(2):241-9. PMID: 1569376.
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  101. Ong JM, Saffari B, Simsolo RB, Kern PA. Epinephrine inhibits lipoprotein lipase gene expression in rat adipocytes through multiple steps in posttranscriptional processing. Mol Endocrinol. 1992 Jan; 6(1):61-9. PMID: 1738372.
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  102. Simsolo RB, Ong JM, Saffari B, Kern PA. Effect of improved diabetes control on the expression of lipoprotein lipase in human adipose tissue. J Lipid Res. 1992 Jan; 33(1):89-95. PMID: 1552236.
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  103. Wallace DJ, Metzger AL, Stecher VJ, Turnbull BA, Kern PA. Cholesterol-lowering effect of hydroxychloroquine in patients with rheumatic disease: reversal of deleterious effects of steroids on lipids. Am J Med. 1990 Sep; 89(3):322-6. PMID: 2393036.
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  104. Querfeld U, Ong JM, Prehn J, Carty J, Saffari B, Jordan SC, Kern PA. Effects of cytokines on the production of lipoprotein lipase in cultured human macrophages. J Lipid Res. 1990 Aug; 31(8):1379-86. PMID: 2126274.
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  105. Kern PA, Ong JM, Saffari B, Carty J. The effects of weight loss on the activity and expression of adipose-tissue lipoprotein lipase in very obese humans. N Engl J Med. 1990 Apr 12; 322(15):1053-9. PMID: 2320065.
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  106. Kern PA, Martin RA, Carty J, Goldberg IJ, Ong JM. Identification of lipoprotein lipase immunoreactive protein in pre- and postheparin plasma from normal subjects and patients with type I hyperlipoproteinemia. J Lipid Res. 1990 Jan; 31(1):17-26. PMID: 2313202.
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  107. Knedler A, Eckel RH, Kern PA, Ham RG. Microvascular endothelial cell cultures from human omental adipose tissue. In Vitro Cell Dev Biol. 1989 Oct; 25(10):863-4. PMID: 2624640.
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  108. Ong JM, Kern PA. Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue. J Clin Invest. 1989 Jul; 84(1):305-11. PMID: 2738155.
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  109. Kern PA, Svoboda ME, Eckel RH, Van Wyk JJ. Insulinlike growth factor action and production in adipocytes and endothelial cells from human adipose tissue. Diabetes. 1989 Jun; 38(6):710-7. PMID: 2542108.
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  110. Ong JM, Kern PA. The role of glucose and glycosylation in the regulation of lipoprotein lipase synthesis and secretion in rat adipocytes. J Biol Chem. 1989 Feb 25; 264(6):3177-82. PMID: 2644281.
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  111. Ong JM, Kirchgessner TG, Schotz MC, Kern PA. Insulin increases the synthetic rate and messenger RNA level of lipoprotein lipase in isolated rat adipocytes. J Biol Chem. 1988 Sep 15; 263(26):12933-8. PMID: 3047113.
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  112. Kern PA. Recombinant human tumor necrosis factor does not inhibit lipoprotein lipase in primary cultures of isolated human adipocytes. J Lipid Res. 1988 Jul; 29(7):909-14. PMID: 3411249.
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  113. Kern PA, Ong JM, Goers JW, Pedersen ME. Regulation of lipoprotein lipase immunoreactive mass in isolated human adipocytes. J Clin Invest. 1988 Feb; 81(2):398-406. PMID: 3276727.
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  114. Kern PA, Mandic A, Eckel RH. Regulation of lipoprotein lipase by glucose in primary cultures of isolated human adipocytes. Relevance to hypertriglyceridemia of diabetes. Diabetes. 1987 Nov; 36(11):1238-45. PMID: 3666316.
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  115. Goers JW, Pedersen ME, Kern PA, Ong J, Schotz MC. An enzyme-linked immunoassay for lipoprotein lipase. Anal Biochem. 1987 Oct; 166(1):27-35. PMID: 3674413.
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  116. Kern PA. Lipid disorders in diabetes mellitus. Mt Sinai J Med. 1987 Mar; 54(3):245-52. PMID: 3295530.
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  117. Kern PA, Robbins RJ, Bichet D, Berl T, Verbalis JG. Syndrome of inappropriate antidiuresis in the absence of arginine vasopressin. J Clin Endocrinol Metab. 1986 Jan; 62(1):148-52. PMID: 3940262.
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  118. Kern PA, Marshall S, Eckel RH. Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes. J Clin Invest. 1985 Jan; 75(1):199-208. PMID: 3880772.
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  119. Robbins RJ, Kern PA, Thompson TL. Interactions between thioridazine and bromocriptine in a patient with a prolactin-secreting pituitary adenoma. Am J Med. 1984 May; 76(5):921-3. PMID: 6720732.
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  120. Eckel RH, Prasad JE, Kern PA, Marshall S. Insulin regulation of lipoprotein lipase in cultured isolated rat adipocytes. Endocrinology. 1984 May; 114(5):1665-71. PMID: 6370664.
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  121. Kern PA, Eckel RH. Absence of lipoprotein lipase in cultured human adipose stromal cells. Arteriosclerosis. 1984 May-Jun; 4(3):232-7. PMID: 6712537.
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  122. Kern PA, Knedler A, Eckel RH. Isolation and culture of microvascular endothelium from human adipose tissue. J Clin Invest. 1983 Jun; 71(6):1822-9. PMID: 6306056.
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