Edward A. Hirschowitz, MD

Clinical interests

  • Critical Care
  • Lung Cancer
  • Pulmonary Medicine

Edward A. Hirschowitz, MD

Biography

My name is Edward Hirschowitz; I received my medical degree from the University of Alabama, School of Medicine, Birmingham. I then completed fellowships at New York Hospital, Cornell Medical Center and the National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md.

I am board certified by the American Board of Internal Medicine in Critical Care Medicine and Pulmonary Disease.

Faculty rank

Associate Professor of Medicine

Education

Degree
University of Alabama, School of Medicine, Birmingham

Residency
University of Minnesota Medical School, Minneapolis

Fellowship
New York Hospital, Cornell Medical Center
National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md.

Certifications or Special training
American Board of Internal Medicine
American Board of Internal Medicine, Pulmonary Disease
American Board of Internal Medicine, Critical Care Medicine

Pulmonary, Critical Care and Sleep Medicine

UK Sleep Disorders Center

UK Good Samaritan Hospital
310 S. Limestone
Lexington KY 40508-3008

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This is a clinic of the University of Kentucky Hospital, also known as UK Albert B. Chandler Hospital. Read more »

Call 859-226-7006
Fax 859-226-7008

Hours of operation/technical staff available

Monday - Saturday, 8 p.m. - 6 a.m. 

Business office hours

Monday - Friday, 8 a.m. - 4:30 p.m. 

Amenities
ATM, Chaplain, Chapel, Communication assistance, Dining, Fax and copy machines, Gift shop, Guest accommodations, Internet/Wi-Fi, Lost & found, Notary, Parking, Patient & family services, Pharmacy services, Public transportation, Showers, Telephones

Directions to UK Good Samaritan Hospital Parking »



Lung Cancer

Multidisciplinary Clinic

Markey Cancer Center
Whitney-Hendrickson Building
First Floor
800 Rose St.
Lexington KY 40536-0098

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This is a clinic of the University of Kentucky Hospital, also known as UK Albert B. Chandler Hospital. Read more »

Call 859-257-4488
Call 866-340-4488

Directions to Markey Cancer Center »


UK HealthCare accepts many forms of insurance. See list of insurers »

 
  1. Cahall CF, Lilly JL, Hirschowitz EA, Berron BJ. A Quantitative Perspective on Surface Marker Selection for the Isolation of Functional Tumor Cells. Breast Cancer (Auckl). 2015;9(Suppl 1):1-11.
    View in: PubMed
  2. Trudgen K, Khattar NH, Bensadoun E, Arnold S, Stromberg AJ, Hirschowitz EA. Autoantibody profiling for lung cancer screening longitudinal retrospective analysis of CT screening cohorts. PLoS One. 2014;9(2):e87947..
    View in: PubMed
  3. Hirschowitz EA, Mullins A, Prajapati D, Baeker T, Kloecker G, Foody T, Damron K, Love C, Yannelli JR. Pilot study of 1650-G: a simplified cellular vaccine for lung cancer. J Thorac Oncol. 2011 Jan; 6(1):169-73. PMID: 21150468.
    View in: PubMed
  4. Khattar NH, Coe-Atkinson SP, Stromberg AJ, Jett JR, Hirschowitz EA. Lung cancer-associated auto-antibodies measured using seven amino acid peptides in a diagnostic blood test for lung cancer. Cancer Biol Ther. 2010 Aug; 10(3):267-72. PMID: 20543565.
    View in: PubMed
  5. Yannelli JR, Tucker JA, Hidalgo G, Perkins S, Kryscio R, Hirschowitz EA. Characteristics of PBMC obtained from leukapheresis products and tumor biopsies of patients with non-small cell lung cancer. Oncol Rep. 2009 Dec; 22(6):1459-71. PMID: 19885600.
    View in: PubMed
  6. Hirschowitz EA, Yannelli JR. Immunotherapy for lung cancer. Proc Am Thorac Soc. 2009 Apr 15; 6(2):224-32. PMID: 19349492.
    View in: PubMed
  7. Hirschowitz EA. Biomarkers for lung cancer screening: interpretation and implications of an early negative advanced validation study. Am J Respir Crit Care Med. 2009 Jan 1; 179(1):1-2. PMID: 19098155.
    View in: PubMed
  8. Hirschowitz EA, Foody T, Hidalgo GE, Yannelli JR. Immunization of NSCLC patients with antigen-pulsed immature autologous dendritic cells. Lung Cancer. 2007 Sep; 57(3):365-72. PMID: 17509725.
    View in: PubMed
  9. Zhong L, Coe SP, Stromberg AJ, Khattar NH, Jett JR, Hirschowitz EA. Profiling tumor-associated antibodies for early detection of non-small cell lung cancer. J Thorac Oncol. 2006 Jul; 1(6):513-9. PMID: 17409910.
    View in: PubMed
  10. Hirschowitz EA, Hiestand DM, Yannelli JR. Vaccines for lung cancer. J Thorac Oncol. 2006 Jan; 1(1):93-104. PMID: 17409835.
    View in: PubMed
  11. Zhong L, Hidalgo GE, Stromberg AJ, Khattar NH, Jett JR, Hirschowitz EA. Using protein microarray as a diagnostic assay for non-small cell lung cancer. Am J Respir Crit Care Med. 2005 Nov 15; 172(10):1308-14. PMID: 16109979.
    View in: PubMed
  12. Yannelli JR, Sturgill J, Foody T, Hirschowitz E. The large scale generation of dendritic cells for the immunization of patients with non-small cell lung cancer (NSCLC). Lung Cancer. 2005 Mar; 47(3):337-50. PMID: 15713517.
    View in: PubMed
  13. Hirschowitz EA, Foody T, Kryscio R, Dickson L, Sturgill J, Yannelli J. Autologous dendritic cell vaccines for non-small-cell lung cancer. J Clin Oncol. 2004 Jul 15; 22(14):2808-15. PMID: 15254048.
    View in: PubMed
  14. Zhong L, Peng X, Hidalgo GE, Doherty DE, Stromberg AS, Hirschowitz EA. Efficient identification and use of tumor-associated antibodies as markers of non-small cell lung cancer. Chest. 2004 May; 125(5 Suppl):105S-6S. PMID: 15136442.
    View in: PubMed
  15. Zhong L, Peng X, Hidalgo GE, Doherty DE, Stromberg AJ, Hirschowitz EA. Identification of circulating antibodies to tumor-associated proteins for combined use as markers of non-small cell lung cancer. Proteomics. 2004 Apr; 4(4):1216-25. PMID: 15049001.
    View in: PubMed
  16. Zhong L, Peng X, Hidalgo GE, Doherty DE, Stromberg AJ, Hirschowitz EA. Antibodies to HSP70 and HSP90 in serum in non-small cell lung cancer patients. Cancer Detect Prev. 2003; 27(4):285-90. PMID: 12893076.
    View in: PubMed
  17. Hidalgo GE, Zhong L, Doherty DE, Hirschowitz EA. Plasma PGE-2 levels and altered cytokine profiles in adherent peripheral blood mononuclear cells in non-small cell lung cancer (NSCLC). Mol Cancer. 2002 Nov 12; 1:5. PMID: 12459041.
    View in: PubMed
  18. Shih WJ, Bensadoun ES, Hirschowitz E, Kieffer V, Gross K. Comparative SPECT findings of Tc-99m depreotide, Tc-99m tetrofosmin, and Tl-201 chloride for bronchogenic carcinoma. Clin Nucl Med. 2002 Sep; 27(9):676-9. PMID: 12192295.
    View in: PubMed
  19. Shih WJ, Hirschowitz E, Bensadoun E, Woodring J, Ryo YU, Kraman S. Biodistribution on Tc-99m labeled somatostatin receptor-binding peptide (Depreotide, NeoTec) planar and SPECT studies. Ann Nucl Med. 2002 May; 16(3):213-9. PMID: 12126047.
    View in: PubMed
  20. Hirschowitz EA, Hidalgo GE, Doherty DE. Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by adenovirus vector information. Chest. 2002 Mar; 121(3 Suppl):32S. PMID: 11893673.
    View in: PubMed
  21. Hirschowitz E, Hidalgo G, Doherty D. Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by infection with DeltaE1, DeltaE3 recombinant adenovirus vectors. Gene Ther. 2002 Jan; 9(1):81-4. PMID: 11850726.
    View in: PubMed
  22. Hirschowitz EA, Weaver JD, Hidalgo GE, Doherty DE. Murine dendritic cells infected with adenovirus vectors show signs of activation. Gene Ther. 2000 Jul; 7(13):1112-20. PMID: 10918477.
    View in: PubMed
  23. Hirschowitz EA, Naama HA, Evoy D, Lieberman MD, Daly J, Crystal RG. Regional treatment of hepatic micrometastasis by adenovirus vector-mediated delivery of interleukin-2 and interleukin-12 cDNAs to the hepatic parenchyma. Cancer Gene Ther. 1999 Nov-Dec; 6(6):491-8. PMID: 10608345.
    View in: PubMed
  24. Harvey BG, Hackett NR, El-Sawy T, Rosengart TK, Hirschowitz EA, Lieberman MD, Lesser ML, Crystal RG. Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs. J Virol. 1999 Aug; 73(8):6729-42. PMID: 10400771.
    View in: PubMed
  25. Hirschowitz EA, Crystal RG. Adenovirus-mediated expression of interleukin-12 induces natural killer cell activity and complements adenovirus-directed gp75 treatment of melanoma lung metastases. Am J Respir Cell Mol Biol. 1999 May; 20(5):935-41. PMID: 10226063.
    View in: PubMed
  26. Hirschowitz EA, Leonard S, Song W, Ferris B, Leopold PL, Lewis JJ, Bowne WB, Wang S, Houghton AN, Crystal RG. Adenovirus-mediated expression of melanoma antigen gp75 as immunotherapy for metastatic melanoma. Gene Ther. 1998 Jul; 5(7):975-83. PMID: 9813669.
    View in: PubMed
  27. Harrell RL, Rajanayagam S, Doanes AM, Guzman RJ, Hirschowitz EA, Crystal RG, Epstein SE, Finkel T. Inhibition of vascular smooth muscle cell proliferation and neointimal accumulation by adenovirus-mediated gene transfer of cytosine deaminase. Circulation. 1997 Jul 15; 96(2):621-7. PMID: 9244235.
    View in: PubMed
  28. Ross HM, Hirschowitz EA, Russi TJ, Crystal RG, Nawata S, Burt ME, Brennan MF, Lewis JJ. Adenoviral thymidine kinase prodrug gene therapy inhibits sarcoma growth in vivo. J Surg Res. 1997 Jun; 70(1):7-11. PMID: 9228920.
    View in: PubMed
  29. Crystal RG, Hirschowitz E, Lieberman M, Daly J, Kazam E, Henschke C, Yankelevitz D, Kemeny N, Silverstein R, Ohwada A, Russi T, Mastrangeli A, Sanders A, Cooke J, Harvey BG. Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. Hum Gene Ther. 1997 May 20; 8(8):985-1001. PMID: 9195221.
    View in: PubMed
  30. Evoy D, Hirschowitz EA, Naama HA, Li XK, Crystal RG, Daly JM, Lieberman MD. In vivo adenoviral-mediated gene transfer in the treatment of pancreatic cancer. J Surg Res. 1997 Apr; 69(1):226-31. PMID: 9202675.
    View in: PubMed
  31. Russi TJ, Hirschowitz EA, Crystal RG. Delayed-type hypersensitivity response to high doses of adenoviral vectors. Hum Gene Ther. 1997 Feb 10; 8(3):323-30. PMID: 9048199.
    View in: PubMed
  32. Ohwada A, Hirschowitz EA, Crystal RG. Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver. Hum Gene Ther. 1996 Aug 20; 7(13):1567-76. PMID: 8864757.
    View in: PubMed
  33. Dong Y, Wen P, Manome Y, Parr M, Hirshowitz A, Chen L, Hirschowitz EA, Crystal R, Weichselbaum R, Kufe DW, Fine HA. In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Hum Gene Ther. 1996 Apr 10; 7(6):713-20. PMID: 8919593.
    View in: PubMed
  34. Hirschowitz EA, Ohwada A, Pascal WR, Russi TJ, Crystal RG. In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine. Hum Gene Ther. 1995 Aug; 6(8):1055-63. PMID: 7578418.
    View in: PubMed
  35. Guzman RJ, Hirschowitz EA, Brody SL, Crystal RG, Epstein SE, Finkel T. In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10732-6. PMID: 7938020.
    View in: PubMed