John A. D'Orazio, MD, PhD

Clinical interests

  • Genetic Cancer Predisposition
  • Melanoma Biology
  • Pediatric Hematology and Oncology

John A. D'Orazio, MD, PhD


My name is John D’Orazio; I received my medical degree from University of Miami, School of Medicine, Miami, Fla. I then completed a Pediatrics residency at the Massachusetts General Hospital, Boston and a Pediatric Hematology/Oncology fellowship at Boston Children’s Hospital and the Dana-Farber Cancer Institute, Boston.

I am board certified by the American Board of Pediatrics in Hematology/Oncology.

Personal statement

I think it's very important to make a connection with patients and their families. I'll do anything to make that connection with the families because what I've learned is, to effectively take care of a child with cancer, you need everybody on board. It really does take a village and the most important part of that is the family and that child. One of the great things about being a doctor here at the University of Kentucky and at the Markey Cancer Center is our community of providers and support. We really are invested in the shared mission of trying to bring improved health care to the children and patients of Kentucky.

Faculty rank

Associate Professor of Pediatrics


University of Miami, School of Medicine, Miami, Fla.

Massachusetts General Hospital, Boston

Dana-Farber Cancer Institute, Boston

Certifications or Special training
American Board of Pediatrics
American Board of Pediatrics, Hematology/Oncology

Pediatric Hematology and Oncology

The DanceBlue Kentucky Children's Hospital Hematology/Oncology Clinic

Kentucky Children's Hospital
UK Chandler Hospital - Pavilion HA
Fourth Floor
800 Rose St.
Lexington KY 40536-0293

Call 859-257-4554
Fax 859-257-8978

Appointments based on need and availability: Thursdays, 8 a.m.- noon or by appointment

Laundry, Showers

Directions to UK Kentucky Children's Hospital Parking »
Parking is available at the UK HealthCare Parking Garage (PS #8).

Insurance information

Insurance policies can vary widely. Please check with your doctor/clinic for specific insurance information before your visit or procedure to avoid unexpected out-of-pocket costs. See list of insurers »

Referral form for physicians »

John D'Orazio Lab
  1. Wolf Horrell EM, Boulanger MC, D'Orazio JA. Melanocortin 1 Receptor: Structure, Function, and Regulation. Front Genet. 2016;7:95.
    View in: PubMed
  2. Jarrett SG, Wolf Horrell EM, Boulanger MC, D'Orazio JA. Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes. J Invest Dermatol. 2015 Dec;135(12):3086-95.
    View in: PubMed
  3. D'Orazio JA. Melanocyte UV resistance: Feelin' the endothelin. Exp Dermatol. 2015 Jun;24(6):414-5.
    View in: PubMed
  4. Jarrett SG, Wolf Horrell EM, Christian PA, Vanover JC, Boulanger MC, Zou Y, D'Orazio JA. PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage. Mol Cell. 2014 Jun 19;54(6):999-1011.
    View in: PubMed
  5. Amaro-Ortiz A, Yan B, D'Orazio JA. Ultraviolet radiation, aging and the skin: prevention of damage by topical cAMP manipulation. Molecules. 2014;19(5):6202-19.
    View in: PubMed
  6. D'Orazio JA, Neely J, Farhoudi N. ITP in Children: Pathophysiology and Current Treatment Approaches. J Pediatr Hematol Oncol. 2013 Jan; 35(1):1-13. PMID: 23073045.
    View in: PubMed
  7. Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, Bosenberg MW, Haigis KM, Haber DA, Wang Y, Fisher DE. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 2012 Nov 15; 491(7424):449-53. PMID: 23123854.
    View in: PubMed
  8. Scott TL, Christian PA, Kesler MV, Donohue KM, Shelton B, Wakamatsu K, Ito S, D'Orazio J. Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation. Exp Dermatol. 2012 Oct; 21(10):771-7. PMID: 23078399.
    View in: PubMed
  9. Colquitt JL, D'Orazio JA. Intracranial Hemorrhage and a White Blood Cell Count of Almost 1 Million Cells/µL. J Pediatr. 2013 Jan; 162(1):214-214.e1. PMID: 22947653.
    View in: PubMed
  10. Pleasant L, Skinner S, Pulliam J, Challa H, D'Orazio J. Burkitt lymphoma in a child with atopic dermatitis and a 7-year history of regular topical tacrolimus use. Cutis. 2012 Mar; 89(3):117-20. PMID: 22530327.
    View in: PubMed
  11. Bacon M, Maul E, Pulliam J, D'Orazio J. Autoimmune hemolytic anemia in a 2-year-old child with pneumococcal pneumonia. Clin Pediatr (Phila). 2011 Oct; 50(10):974-7. PMID: 21947427.
    View in: PubMed
  12. Romond J, Pulliam J, D'Orazio JA. Chest wall Ewing sarcoma presenting as abdominal pain in a 12-year-old boy. J Pediatr. 2011 Dec; 159(6):1048. PMID: 21962600.
    View in: PubMed
  13. Murapa P, Dai J, Chung M, Mumper RJ, D'Orazio J. Anthocyanin-rich fractions of blackberry extracts reduce UV-induced free radicals and oxidative damage in keratinocytes. Phytother Res. 2012 Jan; 26(1):106-12. PMID: 21567508.
    View in: PubMed
  14. D'Orazio J, Fisher DE. Central role for cAMP signaling in pigmentation and UV resistance. Cell Cycle. 2011 Jan 1; 10(1):8-9. PMID: 21200135.
    View in: PubMed
  15. D'Orazio J, Pulliam J. Hypereosinophilic syndrome presenting as acute myocardial infarction in an adolescent. J Pediatr. 2011 Apr; 158(4):685. PMID: 21074174.
    View in: PubMed
  16. Marsch AF, Shashidhar H, D'Orazio JA. B12 deficient megaloblastic anemia in a toddler with a history of gastroschisis. J Pediatr. 2011 Mar; 158(3):512. PMID: 20961567.
    View in: PubMed
  17. D'Orazio JA. Inherited cancer syndromes in children and young adults. J Pediatr Hematol Oncol. 2010 Apr; 32(3):195-228. PMID: 20186103.
    View in: PubMed
  18. Scott TL, Wakamatsu K, Ito S, D'Orazio JA. Purification and growth of melanocortin 1 receptor (Mc1r)- defective primary murine melanocytes is dependent on stem cell factor (SFC) from keratinocyte-conditioned media. In Vitro Cell Dev Biol Anim. 2009 Dec; 45(10):577-83. PMID: 19633898.
    View in: PubMed
  19. Vanover JC, Spry ML, Hamilton L, Wakamatsu K, Ito S, D'Orazio JA. Stem cell factor rescues tyrosinase expression and pigmentation in discreet anatomic locations in albino mice. Pigment Cell Melanoma Res. 2009 Dec; 22(6):827-38. PMID: 19682281.
    View in: PubMed
  20. Chen J, Hammell DC, Spry M, D'Orazio JA, Stinchcomb AL. In vitro skin diffusion study of pure forskolin versus a forskolin-containing Plectranthus barbatus root extract. J Nat Prod. 2009 Apr; 72(4):769-71. PMID: 19281221.
    View in: PubMed
  21. D'Orazio JA, Burns LA, Farhoudi N, McBride MT, Kesler MV. Acute myelogenous leukemia presenting as acute infectious meningitis in a 7-year-old boy. Clin Pediatr (Phila). 2009 May; 48(4):444-8. PMID: 19224868.
    View in: PubMed
  22. Spry ML, Vanover JC, Scott T, Abona-Ama O, Wakamatsu K, Ito S, D'Orazio JA. Prolonged treatment of fair-skinned mice with topical forskolin causes persistent tanning and UV protection. Pigment Cell Melanoma Res. 2009 Apr; 22(2):219-29. PMID: 19087231.
    View in: PubMed
  23. D'Orazio JA, Pulliam JF, Moscow JA. Spontaneous resolution of a single lesion of myeloid leukemia cutis in an infant: case report and discussion. Pediatr Hematol Oncol. 2008 Jun; 25(5):457-68. PMID: 18569848.
    View in: PubMed
  24. Spry M, Scott T, Pierce H, D'Orazio JA. DNA repair pathways and hereditary cancer susceptibility syndromes. Front Biosci. 2007; 12:4191-207. PMID: 17485367.
    View in: PubMed
  25. Cui R, Widlund HR, Feige E, Lin JY, Wilensky DL, Igras VE, D'Orazio J, Fung CY, Schanbacher CF, Granter SR, Fisher DE. Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell. 2007 Mar 9; 128(5):853-64. PMID: 17350573.
    View in: PubMed
  26. D'Orazio JA, Nobuhisa T, Cui R, Arya M, Spry M, Wakamatsu K, Igras V, Kunisada T, Granter SR, Nishimura EK, Ito S, Fisher DE. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature. 2006 Sep 21; 443(7109):340-4. PMID: 16988713.
    View in: PubMed

At a cooking demonstration with Markey Cancer Center dietitian Siddhi Shroff, our own physician/researcher Dr. John D'Orazio showed us how to make a creamy, silky risotto at home. As always, our cooking demos are free and open to everyone -- be on the lookout for the next demo!