Leigh Ann Callahan, MD

Clinical interests

  • Cardiopulmonary Interactions
  • Critical Care Medicine
  • Muscle Washing in Critical Illness
  • Myopathy
  • Pulmonary Medicine
  • Sepsis

Leigh Ann Callahan, MD

Biography

My name is Leigh Ann Callahan; I received my medical degree from Medical College of Georgia, School of Medicine, Augusta. I then completed a fellowship at Medical College of Georgia, Augusta.

I am board certified by the American Board of Internal Medicine in Critical Care Medicine and Pulmonary Disease.

Faculty rank

Professor of Medicine

Education

Degree
Medical College of Georgia, School of Medicine, Augusta

Residency
Medical College of Georgia, Augusta

Fellowship
Medical College of Georgia, Augusta

Certifications or Special training
American Board of Internal Medicine
American Board of Internal Medicine, Critical Care Medicine
American Board of Internal Medicine, Pulmonary Disease

Pulmonary, Critical Care and Sleep Medicine

UK Good Samaritan Hospital
310 S. Limestone
Lexington KY 40508-3008

Call 859-226-7000

Amenities
ATM, Chaplain, Chapel, Communication assistance, Dining, Fax and copy machines, Gift shop, Guest accommodations, Internet/Wi-Fi, Lost & found, Notary, Parking, Patient & family services, Pharmacy services, Public transportation, Showers, Telephones

Directions to UK Good Samaritan Hospital Parking »



Pulmonary, Critical Care and Sleep Medicine

Kentucky Clinic
Fifth Floor, Wing D, Room L543
740 S. Limestone
Lexington KY 40536-0284

Call 859-323-9555
Fax 800-257-9288

Amenities
Dining, Internet/Wi-Fi, Information desk, Pharmacy services, Wheelchairs

Kentucky Clinic Map (PDF, 616 KB) »
Directions to Kentucky Clinic Parking »


UK HealthCare accepts many forms of insurance. See list of insurers »

 
  1. Callahan LA, Supinski GS. Early Mobilization in the ICU: Help or Hype? Crit Care Med. 2016 Jun;44(6):1239-40.
    View in: PubMed
  2. Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA. Calcium-dependent phospholipase A2 modulates infection-induced diaphragm dysfunction. Am J Physiol Lung Cell Mol Physiol. 2016 May 15;310(10):L975-84.
    View in: PubMed
  3. Supinski GS, Westgate P, Callahan LA. Correlation of maximal inspiratory pressure to transdiaphragmatic twitch pressure in intensive care unit patients. Crit Care. 2016;20:77.
    View in: PubMed
  4. Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA. Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 15;309(6):L614-24.
    View in: PubMed
  5. Supinski GS, Callahan LA. How Important is Diaphragm Function as a Determinant of Outcomes for MICU Patients in Respiratory Failure? Physiology (Bethesda). 2015 Sep;30(5):336-7.
    View in: PubMed
  6. Supinski GS, Callahan LA. Double-stranded RNA-dependent protein kinase activation modulates endotoxin-induced diaphragm weakness. J Appl Physiol. 2011 Jan; 110(1):199-205. PMID: 21071594.
    View in: PubMed
  7. Callahan LA, Supinski GS. Diaphragm weakness and mechanical ventilation--what's the critical issue? Crit Care. 2010; 14(4):187. PMID: 20701738.
    View in: PubMed
  8. Supinski GS, Vanags J, Callahan LA. Eicosapentaenoic acid preserves diaphragm force generation following endotoxin administration. Crit Care. 2010; 14(2):R35. PMID: 20233404.
    View in: PubMed
  9. Callahan LA, Supinski GS. Sepsis-induced myopathy. Crit Care Med. 2009 Oct; 37(10 Suppl):S354-67. PMID: 20046121.
    View in: PubMed
  10. Supinski GS, Ji XY, Callahan LA. p38 Mitogen-activated protein kinase modulates endotoxin-induced diaphragm caspase activation. Am J Respir Cell Mol Biol. 2010 Jul; 43(1):121-7. PMID: 19717815.
    View in: PubMed
  11. Supinski GS, Wang W, Callahan LA. Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weakness. J Appl Physiol. 2009 Nov; 107(5):1389-96. PMID: 19661453.
    View in: PubMed
  12. Supinski GS, Murphy MP, Callahan LA. MitoQ administration prevents endotoxin-induced cardiac dysfunction. Am J Physiol Regul Integr Comp Physiol. 2009 Oct; 297(4):R1095-102. PMID: 19657095.
    View in: PubMed
  13. Supinski GS, Ji X, Callahan LA. The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation. Am J Physiol Regul Integr Comp Physiol. 2009 Sep; 297(3):R825-34. PMID: 19605759.
    View in: PubMed
  14. Supinski GS, Vanags J, Callahan LA. Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L994-L1001. PMID: 19376888.
    View in: PubMed
  15. Supinski GS, Callahan LA. Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction. Am J Respir Cell Mol Biol. 2010 Jan; 42(1):80-7. PMID: 19329553.
    View in: PubMed
  16. Callahan LA, Supinski GS. Hyperglycemia and acquired weakness in critically ill patients: potential mechanisms. Crit Care. 2009; 13(2):125. PMID: 19439021.
    View in: PubMed
  17. Callahan LA. Invited editorial on "acquired respiratory muscle weakness in critically ill patients: what is the role of mechanical ventilation-induced diaphragm dysfunction?". J Appl Physiol. 2009 Feb; 106(2):360-1. PMID: 19023013.
    View in: PubMed
  18. Supinski GS, Callahan LA. Free radical-mediated skeletal muscle dysfunction in inflammatory conditions. J Appl Physiol. 2007 May; 102(5):2056-63. PMID: 17218425.
    View in: PubMed
  19. Supinski GS, Ji X, Wang W, Callahan LA. The extrinsic caspase pathway modulates endotoxin-induced diaphragm contractile dysfunction. J Appl Physiol. 2007 Apr; 102(4):1649-57. PMID: 17218430.
    View in: PubMed
  20. Callahan LA, Supinski GS. Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis. J Appl Physiol. 2007 Jan; 102(1):44-53. PMID: 16916915.
    View in: PubMed
  21. Supinski GS, Callahan LA. Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction. Am J Respir Crit Care Med. 2006 Jun 1; 173(11):1240-7. PMID: 16514113.
    View in: PubMed
  22. Supinski GS, Callahan LA. Caspase activation contributes to endotoxin-induced diaphragm weakness. J Appl Physiol. 2006 Jun; 100(6):1770-7. PMID: 16484358.
    View in: PubMed
  23. Supinski GS, Callahan LA. Hemin prevents cardiac and diaphragm mitochondrial dysfunction in sepsis. Free Radic Biol Med. 2006 Jan 1; 40(1):127-37. PMID: 16337886.
    View in: PubMed
  24. Callahan LA, Supinski GS. Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis. J Appl Physiol. 2005 Sep; 99(3):1120-6. PMID: 16103521.
    View in: PubMed
  25. Supinski GS, Callahan LA. Diaphragmatic free radical generation increases in an animal model of heart failure. J Appl Physiol. 2005 Sep; 99(3):1078-84. PMID: 16103520.
    View in: PubMed
  26. Callahan LA, Supinski GS. Sepsis induces diaphragm electron transport chain dysfunction and protein depletion. Am J Respir Crit Care Med. 2005 Oct 1; 172(7):861-8. PMID: 15994462.
    View in: PubMed
  27. Callahan LA, Woods KF, Mensah GA, Ramsey LT, Barbeau P, Gutin B. Cardiopulmonary responses to exercise in women with sickle cell anemia. Am J Respir Crit Care Med. 2002 May 1; 165(9):1309-16. PMID: 11991885.
    View in: PubMed
  28. Callahan LA, Nethery D, Stofan D, DiMarco A, Supinski G. Free radical-induced contractile protein dysfunction in endotoxin-induced sepsis. Am J Respir Cell Mol Biol. 2001 Feb; 24(2):210-7. PMID: 11159056.
    View in: PubMed
  29. Callahan LA, She ZW, Nosek TM. Superoxide, hydroxyl radical, and hydrogen peroxide effects on single-diaphragm fiber contractile apparatus. J Appl Physiol. 2001 Jan; 90(1):45-54. PMID: 11133892.
    View in: PubMed
  30. Callahan LA, Stofan DA, Szweda LI, Nethery DE, Supinski GS. Free radicals alter maximal diaphragmatic mitochondrial oxygen consumption in endotoxin-induced sepsis. Free Radic Biol Med. 2001 Jan 1; 30(1):129-38. PMID: 11134903.
    View in: PubMed
  31. Nethery D, Callahan LA, Stofan D, Mattera R, DiMarco A, Supinski G. PLA(2) dependence of diaphragm mitochondrial formation of reactive oxygen species. J Appl Physiol. 2000 Jul; 89(1):72-80. PMID: 10904037.
    View in: PubMed
  32. Supinski G, Nethery D, Nosek TM, Callahan LA, Stofan D, DiMarco A. Endotoxin administration alters the force vs. pCa relationship of skeletal muscle fibers. Am J Physiol Regul Integr Comp Physiol. 2000 Apr; 278(4):R891-6. PMID: 10749776.
    View in: PubMed
  33. Supinski G, Stofan D, Callahan LA, Nethery D, DiMarco A. Effects of protein kinase A inhibition on rat diaphragm force generation. Respir Physiol. 2000 Apr; 120(2):115-23. PMID: 10773242.
    View in: PubMed
  34. Stofan DA, Callahan LA, DiMARCO AF, Nethery DE, Supinski GS. Modulation of release of reactive oxygen species by the contracting diaphragm. Am J Respir Crit Care Med. 2000 Mar; 161(3 Pt 1):891-8. PMID: 10712339.
    View in: PubMed
  35. Supinski G, Stofan D, Callahan LA, Nethery D, Nosek TM, DiMarco A. Peroxynitrite induces contractile dysfunction and lipid peroxidation in the diaphragm. J Appl Physiol. 1999 Aug; 87(2):783-91. PMID: 10444640.
    View in: PubMed
  36. Nethery D, Stofan D, Callahan L, DiMarco A, Supinski G. Formation of reactive oxygen species by the contracting diaphragm is PLA(2) dependent. J Appl Physiol. 1999 Aug; 87(2):792-800. PMID: 10444641.
    View in: PubMed