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Heidi L. Weiss, PhD

Cancer Center Member
Markey Research Programs:
    Drug Discovery, Delivery and Translational Therapeutics

Associate Director, Shared Resources and Director, Biostatistics Shared Resource Facility


Department of Surgery
College of Medicine

Research Focus

Design and analysis of early phase clinical trials focusing on Bayesian design and interim monitoring. Statistical analysis of transgenic, xenograft and chemically induced mouse models of cancer.

Contact Information

800 Rose Street
CC448 Roach Building
University of Kentucky
Lexington, Kentucky 40536

Key Publications

  1. Massarweh S, Tham YL, Huang J, Sexton K, Weiss H, Tsimelzon A, Beyer A, Rimawi M, Cai WY, Hilsenbeck S, Fuqua S and Elledge R. A phase II neoadjuvant trial of anastrozole, fulvestrant, and gefitinib in patients with newly diagnosed estrogen receptor positive breast cancer. Breast Cancer Res Treat 129:819-27, 2011.
  2. Weiss HL, Urban DA, Grizzle WE, Cronin KA, Freedman LS, Kelloff GJ, Lieberman R. Bayesian Monitoring of a phase II chemoprevention trial in high risk cohorts for prostate cancer. Urology 57(4A):220-223, 2001.

Five Most Recent Publications (an automated list via PubMed, based on researcher's ID and University of Kentucky)

1.  Kim JT, Liu C, Zaytseva YY, Weiss HL, Townsend CM, Evers BM.
Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells.
Int J Cancer. 2015 Mar;136(6):1475-81.
2.  Rychahou P, Haque F, Shu Y, Zaytseva Y, Weiss HL, Lee EY, Mustain W, Valentino J, Guo P, Evers BM.
Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration.
ACS Nano. 2015 Feb;9(2):1108-16.
3.  Zhou Y, Rychahou P, Wang Q, Weiss HL, Evers BM.
TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium.
Cell Death Dis. 2015;6:e1631.
4.  Zhong Y, Morris DH, Jin L, Patel MS, Karunakaran SK, Fu YJ, Matuszak EA, Weiss HL, Chait BT, Wang QJ.
Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.
J Biol Chem. 2014 Sep;289(38):26021-37.
5.  Zhou Y, Wang Q, Weiss HL, Evers BM.
Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway.
Mol Biol Cell. 2014 Sep;25(18):2882-90.