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Heidi L. Weiss, PhD

Cancer Center Member
Markey Research Programs:
    Drug Discovery, Delivery and Translational Therapeutics

Associate Director, Shared Resources and Director, Biostatistics Shared Resource Facility

Professor

Department of Surgery
College of Medicine

Research Focus

Design and analysis of early phase clinical trials focusing on Bayesian design and interim monitoring. Statistical analysis of transgenic, xenograft and chemically induced mouse models of cancer.

Contact Information

800 Rose Street
CC448 Roach Building
University of Kentucky
Lexington, Kentucky 40536
859-323-0577
heidi.weiss@uky.edu

Key Publications

  1. Massarweh S, Tham YL, Huang J, Sexton K, Weiss H, Tsimelzon A, Beyer A, Rimawi M, Cai WY, Hilsenbeck S, Fuqua S and Elledge R. A phase II neoadjuvant trial of anastrozole, fulvestrant, and gefitinib in patients with newly diagnosed estrogen receptor positive breast cancer. Breast Cancer Res Treat 129:819-27, 2011.
  2. Weiss HL, Urban DA, Grizzle WE, Cronin KA, Freedman LS, Kelloff GJ, Lieberman R. Bayesian Monitoring of a phase II chemoprevention trial in high risk cohorts for prostate cancer. Urology 57(4A):220-223, 2001.

Five Most Recent Publications (an automated list via PubMed, based on researcher's ID and University of Kentucky)

1.  Zhong Y, Morris DH, Jin L, Patel MS, Karunakaran SK, Fu YJ, Matuszak EA, Weiss HL, Chait BT, Wang QJ.
Nrbf2 Protein Suppresses Autophagy by Modulating Atg14L Protein-containing Beclin 1-Vps34 Complex Architecture and Reducing Intracellular Phosphatidylinositol-3 Phosphate Levels.
J Biol Chem. 2014 Sep;289(38):26021-37.
2.  Zhou Y, Wang Q, Weiss HL, Evers BM.
Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway.
Mol Biol Cell. 2014 Sep;25(18):2882-90.
3.  Kim JT, Liu C, Zaytseva YY, Weiss HL, Townsend CM, Evers BM.
Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells.
Int J Cancer. 2014 Aug.
4.  Zaytseva YY, Elliott VA, Rychahou P, Mustain WC, Kim JT, Valentino J, Gao T, O'Connor KL, Neltner JM, Lee EY, Weiss HL, Evers BM.
Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.
Carcinogenesis. 2014 Jun;35(6):1341-51.
5.  Hollis CP, Weiss HL, Evers BM, Gemeinhart RA, Li T.
In vivo investigation of hybrid Paclitaxel nanocrystals with dual fluorescent probes for cancer theranostics.
Pharm Res. 2014 Jun;31(6):1450-9.